The interaction of laser-generated single inertial bubbles (collapse time=121 μs) near a silicon rubber membrane with a shock wave (55 MPa in peak pressure and 1.7 μs in compressive pulse duration) is investigated. The interaction leads to directional, forced asymmetric collapse of the bubble with microjet formation toward the surface. Maximum jet penetration into the membrane is produced during the bubble collapse phase with optimal shock wave arrival time and stand-off distance. Such interaction may provide a unique acoustic means for in vivo microinjection, applicable to targeted delivery of macromolecules and gene vectors to biological tissues. © 2006 The American Physical Society.