Molecular evidence for arterial repair in atherosclerosis.

Journal Article

Atherosclerosis is a chronic inflammatory process and progresses through characteristic morphologic stages. We have shown previously that chronically injecting bone-marrow-derived vascular progenitor cells can effect arterial repair. This repair capacity depends on the age of the injected marrow cells, suggesting a progressive decline in progenitor cell function. We hypothesized that the progression of atherosclerosis coincides with the deteriorating repair capacity of the bone marrow. Here, we ascribe patterns of gene expression that accurately and reproducibly identify specific disease states in murine atherosclerosis. We then use these expression patterns to determine the point in the disease process at which the repair of arteries by competent bone marrow cells ceases to be efficient. We show that the loss of the molecular signature for competent repair is concurrent with the initiation of atherosclerotic lesions. This work provides a previously unreported comprehensive molecular data set using broad-based analysis that links the loss of successful repair with the progression of a chronic illness.

Full Text

Duke Authors

Cited Authors

  • Karra, R; Vemullapalli, S; Dong, C; Herderick, EE; Song, X; Slosek, K; Nevins, JR; West, M; Goldschmidt-Clermont, PJ; Seo, D

Published Date

  • November 15, 2005

Published In

Volume / Issue

  • 102 / 46

Start / End Page

  • 16789 - 16794

PubMed ID

  • 16275914

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0507718102

Language

  • eng

Conference Location

  • United States