Ravi Karra
Assistant Professor of Medicine
Current Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2015
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016
Contact Information
- 247A CARL Building, Durham, NC 27710
- Box 3126 Med Ctr, Durham, NC 27710
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ravi.karra@duke.edu
(919) 684-2449
- Background
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Education, Training, & Certifications
- Resident, Internal Medicine, Brigham and Women's Hospital 2005 - 2008
- M.D., Duke University School of Medicine 2005
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Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2013 - 2015
- Recognition
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In the News
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SEP 21, 2018 Pratt School of Engineering
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- Research
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Selected Grants
- Printed Electronic Biosensors for Point-of-Care Testing of Cardiovascular Biomarkers awarded by National Institutes of Health 2019 - 2024
- Angiogenic Approaches to Stimulate Heart Regeneration awarded by National Institutes of Health 2018 - 2020
- AMG 986_20150183 awarded by Amgen, Inc. 2018 - 2019
- Oral Doses of MYK-491 in Patients with Stable Heart Failure awarded by MyoKardia, Inc. 2018 - 2019
- BMS-986231_Heart Failure awarded by Bristol-Myers Squibb Company 2018 - 2019
- IW-1973 Caplet awarded by Ironwood Pharmaceuticals, Inc. 2017 - 2019
- Biomarkers of Heart Regeneration awarded by National Institutes of Health 2013 - 2018
- MedImmune MED12C02 Coronary Artery Disease awarded by MedImmune, Inc. 2015 - 2016
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Fernandez, CE, Bakovic, M, and Karra, R. "Endothelial Contributions to Zebrafish Heart Regeneration." Journal of Cardiovascular Development and Disease 5, no. 4 (December 11, 2018). (Review) Full Text
- Karra, R, Foglia, MJ, Choi, W-Y, Belliveau, C, DeBenedittis, P, and Poss, KD. "Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish." Proceedings of the National Academy of Sciences of the United States of America 115, no. 35 (August 13, 2018): 8805-8810. Full Text
- Karra, R, Walter, AO, and Wu, SM. "The relationship between cardiac endothelium and fibroblasts: it's complicated." The Journal of Clinical Investigation 127, no. 8 (August 2017): 2892-2894. Full Text
- Goldman, JA, Kuzu, G, Lee, N, Karasik, J, Gemberling, M, Foglia, MJ, Karra, R, Dickson, AL, Sun, F, Tolstorukov, MY, and Poss, KD. "Resolving Heart Regeneration by Replacement Histone Profiling." Developmental Cell 40, no. 4 (February 2017): 392-404.e5. Full Text
- Karra, R, and Poss, KD. "Redirecting cardiac growth mechanisms for therapeutic regeneration." The Journal of Clinical Investigation 127, no. 2 (February 2017): 427-436. (Review) Full Text
- Kang, J, Hu, J, Karra, R, Dickson, AL, Tornini, VA, Nachtrab, G, Gemberling, M, Goldman, JA, Black, BL, and Poss, KD. "Modulation of tissue repair by regeneration enhancer elements." Nature 532, no. 7598 (April 6, 2016): 201-206. Full Text
- Cao, J, Navis, A, Cox, BD, Dickson, AL, Gemberling, M, Karra, R, Bagnat, M, and Poss, KD. "Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration." Development (Cambridge, England) 143, no. 2 (January 2016): 232-243. Full Text
- Karra, R, Knecht, AK, Kikuchi, K, and Poss, KD. "Myocardial NF-κB activation is essential for zebrafish heart regeneration." Proceedings of the National Academy of Sciences of the United States of America 112, no. 43 (October 15, 2015): 13255-13260. Full Text
- Kang, J, Karra, R, and Poss, KD. "Back in Black." Developmental Cell 33, no. 6 (June 2015): 623-624. Full Text
- Gemberling, M, Karra, R, Dickson, AL, and Poss, KD. "Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish." Elife 4 (April 2015). Full Text Open Access Copy
- Wang, J, Karra, R, Dickson, AL, and Poss, KD. "Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration." Developmental Biology 382, no. 2 (October 2013): 427-435. Full Text
- Fang, Y, Gupta, V, Karra, R, Holdway, JE, Kikuchi, K, and Poss, KD. "Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration." Proceedings of the National Academy of Sciences of the United States of America 110, no. 33 (August 2013): 13416-13421. Full Text
- Gupta, V, Gemberling, M, Karra, R, Rosenfeld, GE, Evans, T, and Poss, KD. "An injury-responsive gata4 program shapes the zebrafish cardiac ventricle." Current Biology : Cb 23, no. 13 (July 2013): 1221-1227. Full Text
- Gregoire, S, Karra, R, Passer, D, Deutsch, M-A, Krane, M, Feistritzer, R, Sturzu, A, Domian, I, Saga, Y, and Wu, SM. "Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation." Circulation Research 112, no. 6 (March 2013): 900-910. Full Text
- Gupta, V, Gemberling, M, Karra, R, Rosenfeld, GE, Evans, T, and Poss, KD. "An injury-responsive gata4 program shapes the zebrafish cardiac ventricle." Current Biology 23, no. 13 (2013): 1221-1227. Full Text
- Chen, JX, Krane, M, Deutsch, M-A, Wang, L, Rav-Acha, M, Gregoire, S, Engels, MC, Rajarajan, K, Karra, R, Abel, ED, Wu, JC, Milan, D, and Wu, SM. "Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5." Circulation Research 111, no. 1 (June 2012): 50-55. Full Text
- Chen, JX, Krane, M, Deutsch, M-A, Wang, L, Rav-Acha, M, Gregoire, S, Engels, MC, Rajarajan, K, Karra, R, Abel, ED, Wu, JC, Milan, D, and Wu, SM. "Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5." Circulation research 111, no. 1 (2012): 50-55. Full Text
- Martin, SS, Karra, R, and Mark, DB. "Pheochromocytoma presenting as fever of unknown origin." The American Journal of Medicine 124, no. 2 (February 2011): e5-e6. (Letter) Full Text
- Kaye, KS, and Karra, R. "Mediastinitis." (January 1, 2010): 279-284. (Chapter) Full Text
- Karra, R, and Wu, SM. "Multipotent stem cells in cardiac regenerative therapy." Regenerative Medicine 3, no. 2 (March 2008): 189-198. Full Text
- Liu, Y-H, Karra, R, and Wu, SM. "Cardiovascular Stem Cells in Regenerative Medicine: Ready for Prime Time?." Drug discovery today. Therapeutic strategies 5, no. 4 (January 2008): 201-207. Full Text
- Karra, R, McDermott, L, Connelly, S, Smith, P, Sexton, DJ, and Kaye, KS. "Risk factors for 1-year mortality after postoperative mediastinitis." The Journal of Thoracic and Cardiovascular Surgery 132, no. 3 (September 2006): 537-543. Full Text
- Karra, R, Vemullapalli, S, Dong, C, Herderick, EE, Song, X, Slosek, K, Nevins, JR, West, M, Goldschmidt-Clermont, PJ, and Seo, D. "Molecular evidence for arterial repair in atherosclerosis." Proceedings of the National Academy of Sciences of the United States of America 102, no. 46 (November 7, 2005): 16789-16794. Full Text
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Book Sections
- Karra, R, and Kaye, KS. "Mediastinitis." In Clinical Infectious Disease, Second Edition, 268-272. January 1, 2015. Full Text
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Conference Papers
- Van Kirk, J, and Karra, R. "Recovery of Ventricular Function is a Heterogeneous Phenotype in Patients With Chronic Heart Failure." Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium. Anaheim, CA. November 11, 2017 - November 15, 2017.: LIPPINCOTT WILLIAMS & WILKINS, November 14, 2017. Link to Item
- Goldman, JA, Kuzu, G, Lee, N, Karasik, J, Gemberling, M, Karra, R, Dickson, A, Tolstorukov, MY, and Poss, KD. "Deciphering Heart Regeneration by Histone Exchange Profiling." Annual Joint Meeting of the American-Society-for-Cell-Biology and the European-Molecular-Biology-Organization (ASCB/EMBO). Philadelphia, PA. December 2, 2017 - December 6, 2017.: AMER SOC CELL BIOLOGY, January 1, 2017. Link to Item
- Karra, R, Knecht, A, and Poss, KD. "NF-kappa B Activity is Required for Heart Regeneration." : LIPPINCOTT WILLIAMS & WILKINS, November 25, 2014. Link to Item
- Hauser, ER, Gregory, S, Seo, D, Dobra, A, Iversen, E, Karra, R, Haynes, C, Stenger, J, Xu, H, Wang, LY, Huang, LL, Sketch, M, Vance, J, Kraus, WE, Goldschmidt, P, and Invest, GENECARDAGENDA. "Convergence of genome-wide expression analysis and genome-wide linkage analysis identifies candidate genes for atherosclerosis." October 26, 2004. Link to Item
- Seo, D, Karra, R, Wang, T, Dressman, H, West, M, Nevins, J, and Goldschmidt, P. "Genomic convergence in the study of human and mouse atherosclerosis." October 28, 2003. Link to Item
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