Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Resident, Internal Medicine, Brigham and Women's Hospital 2005 - 2008
  • M.D., Duke University School of Medicine 2005
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2013 - 2015
• Recognition
• 

  In the News

  • SEP 21, 2018

    Pratt School of Engineering

    Listening to Broken Hearts, Saving Lives
• Research
• 

  Selected Grants

  • Printed Electronic Biosensors for Point-of-Care Testing of Cardiovascular Biomarkers awarded by National Institutes of Health 2019 - 2024
  • Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2021
  • Angiogenic Approaches to Stimulate Heart Regeneration awarded by National Institutes of Health 2018 - 2020
  • Oral Doses of MYK-491 in Patients with Stable Heart Failure awarded by MyoKardia, Inc. 2018 - 2020
  • AMG 986_20150183 awarded by Amgen, Inc. 2018 - 2019
  • BMS-986231_Heart Failure awarded by Bristol-Myers Squibb Company 2018 - 2019
  • IW-1973 Caplet awarded by Ironwood Pharmaceuticals, Inc. 2017 - 2019
  • Biomarkers of Heart Regeneration awarded by National Institutes of Health 2013 - 2018
  • A Phase 2a Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Single-Ascending Doses of MEDI6012 in Subjects with Stable Coronary Artery Disease awarded by MedImmune, Inc. 2015 - 2016
• 

  External Relationships

  • Alnylam
  • Intellia
  • LEK Consulting
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Rehorn, Michael R., Rahul S. Loungani, Eric Black-Maier, Amanda C. Coniglio, Ravi Karra, Sean D. Pokorney, and Michel G. Khouri. “Cardiac Implantable Electronic Devices: A Window Into the Evolution of Conduction Disease in Cardiac Amyloidosis.” Jacc Clin Electrophysiol 6, no. 9 (September 2020): 1144–54. https://doi.org/10.1016/j.jacep.2020.04.020.
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    • Bakovic, Melanie, Devang Thakkar, Paige DeBenedittis, Diana C. Chong, Michael C. Thomas, Edwin S. Iversen, and Ravi Karra. “Clonal Analysis of the Neonatal Mouse Heart using Nearest Neighbor Modeling.” J Vis Exp, no. 162 (August 22, 2020). https://doi.org/10.3791/61656.
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    • Voors, Adriaan A., Jean-François Tamby, John G. Cleland, Michael Koren, Leslie B. Forgosh, Dinesh Gupta, Lars H. Lund, et al. “Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial.” Eur J Heart Fail, June 19, 2020. https://doi.org/10.1002/ejhf.1933.
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    • Van Kirk, Jenny, Marat Fudim, Cynthia L. Green, and Ravi Karra. “Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction.” J Cardiovasc Transl Res 13, no. 2 (April 2020): 142–50. https://doi.org/10.1007/s12265-019-09919-9.
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    • Gancz, Dana, Brian C. Raftrey, Gal Perlmoter, Rubén Marín-Juez, Jonathan Semo, Ryota L. Matsuoka, Ravi Karra, et al. “Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration.” Elife 8 (November 8, 2019). https://doi.org/10.7554/eLife.44153.
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    • Abdulrahim, Jawan W., Lydia Coulter Kwee, Elizabeth Grass, Ilene C. Siegler, Redford Williams, Ravi Karra, William E. Kraus, Simon G. Gregory, and Svati H. Shah. “Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1).” J Am Heart Assoc 8, no. 21 (November 5, 2019): e013228. https://doi.org/10.1161/JAHA.119.013228.
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    • Fernandez, Cristina E., Melanie Bakovic, and Ravi Karra. “Endothelial Contributions to Zebrafish Heart Regeneration.” J Cardiovasc Dev Dis 5, no. 4 (December 11, 2018). https://doi.org/10.3390/jcdd5040056.
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    • Karra, Ravi, Matthew J. Foglia, Wen-Yee Choi, Christine Belliveau, Paige DeBenedittis, and Kenneth D. Poss. “Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish.” Proc Natl Acad Sci U S A 115, no. 35 (August 28, 2018): 8805–10. https://doi.org/10.1073/pnas.1722594115.
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    • Karra, Ravi, Agoston O. Walter, and Sean M. Wu. “The relationship between cardiac endothelium and fibroblasts: it's complicated.” J Clin Invest 127, no. 8 (August 1, 2017): 2892–94. https://doi.org/10.1172/JCI95492.
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    • Goldman, Joseph Aaron, Guray Kuzu, Nutishia Lee, Jaclyn Karasik, Matthew Gemberling, Matthew J. Foglia, Ravi Karra, et al. “Resolving Heart Regeneration by Replacement Histone Profiling.” Dev Cell 40, no. 4 (February 27, 2017): 392-404.e5. https://doi.org/10.1016/j.devcel.2017.01.013.
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    • Karra, Ravi, and Kenneth D. Poss. “Redirecting cardiac growth mechanisms for therapeutic regeneration.” J Clin Invest 127, no. 2 (February 1, 2017): 427–36. https://doi.org/10.1172/JCI89786.
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    • Kang, Junsu, Jianxin Hu, Ravi Karra, Amy L. Dickson, Valerie A. Tornini, Gregory Nachtrab, Matthew Gemberling, Joseph A. Goldman, Brian L. Black, and Kenneth D. Poss. “Modulation of tissue repair by regeneration enhancer elements.” Nature 532, no. 7598 (April 14, 2016): 201–6. https://doi.org/10.1038/nature17644.
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    • Cao, Jingli, Adam Navis, Ben D. Cox, Amy L. Dickson, Matthew Gemberling, Ravi Karra, Michel Bagnat, and Kenneth D. Poss. “Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.” Development 143, no. 2 (January 15, 2016): 232–43. https://doi.org/10.1242/dev.130534.
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    • Karra, Ravi, Anne K. Knecht, Kazu Kikuchi, and Kenneth D. Poss. “Myocardial NF-κB activation is essential for zebrafish heart regeneration.” Proc Natl Acad Sci U S A 112, no. 43 (October 27, 2015): 13255–60. https://doi.org/10.1073/pnas.1511209112.
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    • Kang, Junsu, Ravi Karra, and Kenneth D. Poss. “Back in Black.” Dev Cell 33, no. 6 (June 22, 2015): 623–24. https://doi.org/10.1016/j.devcel.2015.06.001.
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    • Gemberling, Matthew, Ravi Karra, Amy L. Dickson, and Kenneth D. Poss. “Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish.” Elife 4 (April 1, 2015). https://doi.org/10.7554/eLife.05871.
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    • Wang, Jinhu, Ravi Karra, Amy L. Dickson, and Kenneth D. Poss. “Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration.” Dev Biol 382, no. 2 (October 15, 2013): 427–35. https://doi.org/10.1016/j.ydbio.2013.08.012.
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    • Fang, Yi, Vikas Gupta, Ravi Karra, Jennifer E. Holdway, Kazu Kikuchi, and Kenneth D. Poss. “Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration.” Proc Natl Acad Sci U S A 110, no. 33 (August 13, 2013): 13416–21. https://doi.org/10.1073/pnas.1309810110.
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    • Gupta, Vikas, Matthew Gemberling, Ravi Karra, Gabriel E. Rosenfeld, Todd Evans, and Kenneth D. Poss. “An injury-responsive gata4 program shapes the zebrafish cardiac ventricle.” Curr Biol 23, no. 13 (July 8, 2013): 1221–27. https://doi.org/10.1016/j.cub.2013.05.028.
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    • Gregoire, Serge, Ravi Karra, Derek Passer, Marcus-André Deutsch, Markus Krane, Rebecca Feistritzer, Anthony Sturzu, Ibrahim Domian, Yumiko Saga, and Sean M. Wu. “Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation.” Circ Res 112, no. 6 (March 15, 2013): 900–910. https://doi.org/10.1161/CIRCRESAHA.113.259259.
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    • Chen, Jenny X., Markus Krane, Marcus-Andre Deutsch, Li Wang, Moshe Rav-Acha, Serge Gregoire, Marc C. Engels, et al. “Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5.” Circ Res 111, no. 1 (June 22, 2012): 50–55. https://doi.org/10.1161/CIRCRESAHA.112.270264.
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    • Martin, Seth S., Ravi Karra, and Daniel B. Mark. “Pheochromocytoma presenting as fever of unknown origin.” Am J Med 124, no. 2 (February 2011): e5–6. https://doi.org/10.1016/j.amjmed.2010.05.031.
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    • Kaye, K. S., and R. Karra. “Mediastinitis,” January 1, 2010, 279–84. https://doi.org/10.1017/CBO9780511722240.040.
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    • Karra, Ravi, and Sean M. Wu. “Multipotent stem cells in cardiac regenerative therapy.” Regen Med 3, no. 2 (March 2008): 189–98. https://doi.org/10.2217/17460751.3.2.189.
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    • Liu, Yuan-Hung, Ravi Karra, and Sean M. Wu. “Cardiovascular Stem Cells in Regenerative Medicine: Ready for Prime Time?” Drug Discov Today Ther Strateg 5, no. 4 (2008): 201–7. https://doi.org/10.1016/j.ddstr.2008.12.003.
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    • Karra, Ravi, Lisa McDermott, Sarah Connelly, Peter Smith, Daniel J. Sexton, and Keith S. Kaye. “Risk factors for 1-year mortality after postoperative mediastinitis.” J Thorac Cardiovasc Surg 132, no. 3 (September 2006): 537–43. https://doi.org/10.1016/j.jtcvs.2006.04.037.
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    • Karra, Ravi, Sreekanth Vemullapalli, Chunming Dong, Edward E. Herderick, Xiaohua Song, Kathy Slosek, Joseph R. Nevins, Mike West, Pascal J. Goldschmidt-Clermont, and David Seo. “Molecular evidence for arterial repair in atherosclerosis.” Proc Natl Acad Sci U S A 102, no. 46 (November 15, 2005): 16789–94. https://doi.org/10.1073/pnas.0507718102.
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  • Book Sections

    • Nafissi, Navid A., Paige DeBenedittis, Michael C. Thomas, and Ravi Karra. “Differentiation of Human Induced Pluripotent Stem Cells into Epicardial-Like Cells.,” 2158:141–53, 2021. https://doi.org/10.1007/978-1-0716-0668-1_11.
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    • Karra, R., and K. S. Kaye. “Mediastinitis.” In Clinical Infectious Disease, Second Edition, 268–72, 2015. https://doi.org/10.1017/CBO9781139855952.047.
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  • Conference Papers

    • Felker, G Michael, John McMurray, John Cleland, Christopher O’Connor, John Teerlink, Adriaan Voors, Ninian Lang, et al. “HEMODYNAMIC EFFECTS OF NITROXYL DONOR BMS-986231 COMPARED TO NITROGLYCERIN OR PLACEBO IN PATIENTS WITH CHRONIC HEART FAILURE-A RANDOMIZED DOUBLE-BLIND CROSSOVER TRIAL.” In Journal of the American College of Cardiology, 75:850–850. ELSEVIER SCIENCE INC, 2020.
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    • Mandawat, Aditya, Anant Mandawat, Priya Vijayvargiya, and Ravi Karra. “Reduced Gastrointestinal Bleeding in Patients With Improved Left Ventricular Function After Left Ventricular Assist Device Implantation.” In Circulation, Vol. 138, 2018.
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    • Van Kirk, Jenny, and Ravi Karra. “Recovery of Ventricular Function is a Heterogeneous Phenotype in Patients With Chronic Heart Failure.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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    • Goldman, J. A., G. Kuzu, N. Lee, J. Karasik, M. Gemberling, R. Karra, A. Dickson, M. Y. Tolstorukov, and K. D. Poss. “Deciphering Heart Regeneration by Histone Exchange Profiling.” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.
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    • Karra, Ravi, Anne Knecht, and Kenneth D. Poss. “NF-kappa B Activity is Required for Heart Regeneration.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.
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    • Hauser, E. R., S. Gregory, D. Seo, A. Dobra, E. Iversen, R. Karra, C. Haynes, et al. “Convergence of genome-wide expression analysis and genome-wide linkage analysis identifies candidate genes for atherosclerosis.” In Circulation, 110:823–823. LIPPINCOTT WILLIAMS & WILKINS, 2004.
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    • Seo, D., R. Karra, T. Wang, H. Dressman, M. West, J. Nevins, and P. Goldschmidt. “Genomic convergence in the study of human and mouse atherosclerosis.” In Circulation, 108:282–282. LIPPINCOTT WILLIAMS & WILKINS, 2003.
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Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.