Ravi Karra | Scholars@Duke

Ravi Karra
Associate Professor of Medicine

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Cardiology, Medicine 2021
Associate Professor of Pathology, Pathology, Clinical Science Departments 2021
Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021

Contact Information

247A CARL Building, Durham, NC 27710
Box 102152 Med Ctr, Durham, NC 27710
ravi.karra@duke.edu (919) 684-2449

Background
Education, Training, & Certifications
- Resident, Internal Medicine, Brigham and Women's Hospital 2005 - 2008
- M.D., Duke University School of Medicine 2005
Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2015 - 2021
- Assistant Professor - Track - IV of Pathology, Pathology, Clinical Science Departments 2020 - 2021
- Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2013 - 2015
Recognition
In the News
- SEP 21, 2018 Pratt School of Engineering
  
  Listening to Broken Hearts, Saving Lives
Research
Selected Grants
- Myovascular Mechanisms of Cardiac Growth and Regeneration awarded by National Institutes of Health 2022 - 2026
- Mechanisms Regulating Vascular Homeostasis awarded by National Institutes of Health 2021 - 2025
- Epithelioid Mechanisms of Sarcoidosis awarded by Ann Theodore Foundation 2022 - 2024
- Printed Electronic Biosensors for Point-of-Care Testing of Cardiovascular Biomarkers awarded by National Institutes of Health 2019 - 2024
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2023
- MYK-461-019 (EMBARK) awarded by MyoKardia, Inc. 2021 - 2023
- Angiogenic Approaches to Stimulate Heart Regeneration awarded by National Institutes of Health 2018 - 2020
- Oral Doses of MYK-491 in Patients with Stable Heart Failure awarded by MyoKardia, Inc. 2018 - 2020
- AMG 986_20150183 awarded by Amgen, Inc. 2018 - 2019
- BMS-986231_Heart Failure awarded by Bristol-Myers Squibb Company 2018 - 2019
- IW-1973 Caplet awarded by Ironwood Pharmaceuticals, Inc. 2017 - 2019
- Biomarkers of Heart Regeneration awarded by National Institutes of Health 2013 - 2018
- A Phase 2a Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Single-Ascending Doses of MEDI6012 in Subjects with Stable Coronary Artery Disease awarded by MedImmune, Inc. 2015 - 2016
External Relationships
- Alnylam
- McGraw-Hill Publishing
- Sarepta Therapeutics
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Henry, Albert, María Gordillo-Marañón, Chris Finan, Amand F. Schmidt, João Pedro Ferreira, Ravi Karra, Johan Sundström, et al. “Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization.” Circulation 145, no. 16 (April 19, 2022): 1205–17. https://doi.org/10.1161/CIRCULATIONAHA.121.056663.
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  - Olsen, Cameron, Aditya Mandawat, Jie-Lena Sun, Taylor Triana, Karen Chiswell, and Ravi Karra. “Recovery of left ventricular function is associated with improved outcomes in LVAD recipients.” J Heart Lung Transplant, March 17, 2022. https://doi.org/10.1016/j.healun.2022.03.008.
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  - Scherba, Jacob C., Ravi Karra, Joseph W. Turek, and Nenad Bursac. “Toward improved understanding of cardiac development and congenital heart disease: The advent of cardiac organoids.” J Thorac Cardiovasc Surg, February 23, 2022. https://doi.org/10.1016/j.jtcvs.2022.02.028.
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  - Chen, Xinlin J., Emma T. LaPorte, Cameron Olsen, Leslie M. Collins, Priyesh Patel, Ravi Karra, and Boyla O. Mainsah. “Heart Sound Analysis in Individuals Supported With Left Ventricular Assist Devices.” Ieee Trans Biomed Eng 68, no. 10 (October 2021): 3009–18. https://doi.org/10.1109/TBME.2021.3060718.
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  - Lang, Ninian N., Faheem A. Ahmad, John G. Cleland, Christopher M. O’Connor, John R. Teerlink, Adriaan A. Voors, Jorg Taubel, et al. “Haemodynamic effects of the nitroxyl donor cimlanod (BMS-986231) in chronic heart failure: a randomized trial.” Eur J Heart Fail 23, no. 7 (July 2021): 1147–55. https://doi.org/10.1002/ejhf.2138.
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  - Mainsah, Boyla O., Priyesh A. Patel, Xinlin J. Chen, Cameron Olsen, Leslie M. Collins, and Ravi Karra. “Novel Acoustic Biomarker of Quality of Life in Left Ventricular Assist Device Recipients.” J Am Heart Assoc 10, no. 6 (March 16, 2021): e018588. https://doi.org/10.1161/JAHA.120.018588.
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  - Brezitski, Kyla D., Alexander W. Goff, Paige DeBenedittis, and Ravi Karra. “A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals.” Curr Cardiol Rep 23, no. 4 (March 2, 2021): 29. https://doi.org/10.1007/s11886-021-01459-6.
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  - Voors, Adriaan A., Jean-François Tamby, John G. Cleland, Michael Koren, Leslie B. Forgosh, Dinesh Gupta, Lars H. Lund, et al. “Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial.” Eur J Heart Fail 22, no. 9 (September 2020): 1649–58. https://doi.org/10.1002/ejhf.1933.
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  - Rehorn, Michael R., Rahul S. Loungani, Eric Black-Maier, Amanda C. Coniglio, Ravi Karra, Sean D. Pokorney, and Michel G. Khouri. “Cardiac Implantable Electronic Devices: A Window Into the Evolution of Conduction Disease in Cardiac Amyloidosis.” Jacc Clin Electrophysiol 6, no. 9 (September 2020): 1144–54. https://doi.org/10.1016/j.jacep.2020.04.020.
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  - Bakovic, Melanie, Devang Thakkar, Paige DeBenedittis, Diana C. Chong, Michael C. Thomas, Edwin S. Iversen, and Ravi Karra. “Clonal Analysis of the Neonatal Mouse Heart using Nearest Neighbor Modeling.” J Vis Exp, no. 162 (August 22, 2020). https://doi.org/10.3791/61656.
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  - Van Kirk, Jenny, Marat Fudim, Cynthia L. Green, and Ravi Karra. “Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction.” J Cardiovasc Transl Res 13, no. 2 (April 2020): 142–50. https://doi.org/10.1007/s12265-019-09919-9.
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  - Gancz, Dana, Brian C. Raftrey, Gal Perlmoter, Rubén Marín-Juez, Jonathan Semo, Ryota L. Matsuoka, Ravi Karra, et al. “Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration.” Elife 8 (November 8, 2019). https://doi.org/10.7554/eLife.44153.
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  - Abdulrahim, Jawan W., Lydia Coulter Kwee, Elizabeth Grass, Ilene C. Siegler, Redford Williams, Ravi Karra, William E. Kraus, Simon G. Gregory, and Svati H. Shah. “Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1).” J Am Heart Assoc 8, no. 21 (November 5, 2019): e013228. https://doi.org/10.1161/JAHA.119.013228.
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  - Fernandez, Cristina E., Melanie Bakovic, and Ravi Karra. “Endothelial Contributions to Zebrafish Heart Regeneration.” J Cardiovasc Dev Dis 5, no. 4 (December 11, 2018). https://doi.org/10.3390/jcdd5040056.
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  - Karra, Ravi, Matthew J. Foglia, Wen-Yee Choi, Christine Belliveau, Paige DeBenedittis, and Kenneth D. Poss. “Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish.” Proc Natl Acad Sci U S A 115, no. 35 (August 28, 2018): 8805–10. https://doi.org/10.1073/pnas.1722594115.
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  - Karra, Ravi, Agoston O. Walter, and Sean M. Wu. “The relationship between cardiac endothelium and fibroblasts: it's complicated.” J Clin Invest 127, no. 8 (August 1, 2017): 2892–94. https://doi.org/10.1172/JCI95492.
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  - Goldman, Joseph Aaron, Guray Kuzu, Nutishia Lee, Jaclyn Karasik, Matthew Gemberling, Matthew J. Foglia, Ravi Karra, et al. “Resolving Heart Regeneration by Replacement Histone Profiling.” Developmental Cell 40, no. 4 (February 2017): 392-404.e5. https://doi.org/10.1016/j.devcel.2017.01.013.
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  - Karra, Ravi, and Kenneth D. Poss. “Redirecting cardiac growth mechanisms for therapeutic regeneration.” J Clin Invest 127, no. 2 (February 1, 2017): 427–36. https://doi.org/10.1172/JCI89786.
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  - Kang, Junsu, Jianxin Hu, Ravi Karra, Amy L. Dickson, Valerie A. Tornini, Gregory Nachtrab, Matthew Gemberling, Joseph A. Goldman, Brian L. Black, and Kenneth D. Poss. “Modulation of tissue repair by regeneration enhancer elements.” Nature 532, no. 7598 (April 14, 2016): 201–6. https://doi.org/10.1038/nature17644.
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  - Cao, Jingli, Adam Navis, Ben D. Cox, Amy L. Dickson, Matthew Gemberling, Ravi Karra, Michel Bagnat, and Kenneth D. Poss. “Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.” Development 143, no. 2 (January 15, 2016): 232–43. https://doi.org/10.1242/dev.130534.
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  - Karra, Ravi, Anne K. Knecht, Kazu Kikuchi, and Kenneth D. Poss. “Myocardial NF-κB activation is essential for zebrafish heart regeneration.” Proc Natl Acad Sci U S A 112, no. 43 (October 27, 2015): 13255–60. https://doi.org/10.1073/pnas.1511209112.
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  - Kang, Junsu, Ravi Karra, and Kenneth D. Poss. “Back in Black.” Dev Cell 33, no. 6 (June 22, 2015): 623–24. https://doi.org/10.1016/j.devcel.2015.06.001.
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  - Gemberling, Matthew, Ravi Karra, Amy L. Dickson, and Kenneth D. Poss. “Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish.” Elife 4 (April 1, 2015). https://doi.org/10.7554/eLife.05871.
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  - Wang, Jinhu, Ravi Karra, Amy L. Dickson, and Kenneth D. Poss. “Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration.” Dev Biol 382, no. 2 (October 15, 2013): 427–35. https://doi.org/10.1016/j.ydbio.2013.08.012.
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  - Fang, Yi, Vikas Gupta, Ravi Karra, Jennifer E. Holdway, Kazu Kikuchi, and Kenneth D. Poss. “Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration.” Proc Natl Acad Sci U S A 110, no. 33 (August 13, 2013): 13416–21. https://doi.org/10.1073/pnas.1309810110.
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  - Gupta, Vikas, Matthew Gemberling, Ravi Karra, Gabriel E. Rosenfeld, Todd Evans, and Kenneth D. Poss. “An injury-responsive gata4 program shapes the zebrafish cardiac ventricle.” Curr Biol 23, no. 13 (July 8, 2013): 1221–27. https://doi.org/10.1016/j.cub.2013.05.028.
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  - Gregoire, Serge, Ravi Karra, Derek Passer, Marcus-André Deutsch, Markus Krane, Rebecca Feistritzer, Anthony Sturzu, Ibrahim Domian, Yumiko Saga, and Sean M. Wu. “Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation.” Circ Res 112, no. 6 (March 15, 2013): 900–910. https://doi.org/10.1161/CIRCRESAHA.113.259259.
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  - Chen, Jenny X., Markus Krane, Marcus-Andre Deutsch, Li Wang, Moshe Rav-Acha, Serge Gregoire, Marc C. Engels, et al. “Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5.” Circ Res 111, no. 1 (June 22, 2012): 50–55. https://doi.org/10.1161/CIRCRESAHA.112.270264.
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  - Martin, Seth S., Ravi Karra, and Daniel B. Mark. “Pheochromocytoma presenting as fever of unknown origin.” Am J Med 124, no. 2 (February 2011): e5–6. https://doi.org/10.1016/j.amjmed.2010.05.031.
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  - Kaye, K. S., and R. Karra. “Mediastinitis,” January 1, 2010, 279–84. https://doi.org/10.1017/CBO9780511722240.040.
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  - Karra, Ravi, and Sean M. Wu. “Multipotent stem cells in cardiac regenerative therapy.” Regen Med 3, no. 2 (March 2008): 189–98. https://doi.org/10.2217/17460751.3.2.189.
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  - Liu, Yuan-Hung, Ravi Karra, and Sean M. Wu. “Cardiovascular Stem Cells in Regenerative Medicine: Ready for Prime Time?” Drug Discov Today Ther Strateg 5, no. 4 (2008): 201–7. https://doi.org/10.1016/j.ddstr.2008.12.003.
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  - Karra, Ravi, Lisa McDermott, Sarah Connelly, Peter Smith, Daniel J. Sexton, and Keith S. Kaye. “Risk factors for 1-year mortality after postoperative mediastinitis.” J Thorac Cardiovasc Surg 132, no. 3 (September 2006): 537–43. https://doi.org/10.1016/j.jtcvs.2006.04.037.
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  - Karra, Ravi, Sreekanth Vemullapalli, Chunming Dong, Edward E. Herderick, Xiaohua Song, Kathy Slosek, Joseph R. Nevins, Mike West, Pascal J. Goldschmidt-Clermont, and David Seo. “Molecular evidence for arterial repair in atherosclerosis.” Proc Natl Acad Sci U S A 102, no. 46 (November 15, 2005): 16789–94. https://doi.org/10.1073/pnas.0507718102.
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  - DeBenedittis, Paige, Anish Karpurapu, Albert Henry, Michael C. Thomas, Timothy J. McCord, Kyla Brezitski, Anil Prasad, et al. “Coupled myovascular expansion directs cardiac growth and regeneration,” n.d. https://doi.org/10.1101/2021.01.20.425322.
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- Book Sections
  - Nafissi, Navid A., Paige DeBenedittis, Michael C. Thomas, and Ravi Karra. “Differentiation of Human Induced Pluripotent Stem Cells into Epicardial-Like Cells.,” 2158:141–53, 2021. https://doi.org/10.1007/978-1-0716-0668-1_11.
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  - Karra, R., and K. S. Kaye. “Mediastinitis.” In Clinical Infectious Disease, Second Edition, 268–72, 2015. https://doi.org/10.1017/CBO9781139855952.047.
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- Conference Papers
  - Harrington, Josephine, Ravi Karra, Eric Yow, Andrew Nixon, Melissa Daubert, Justin Ezekowitz, Mona Fiuzat, et al. “Angiopoetin 2 Predicts Clinical Outcomes And Recovery Of Ventricular Function In Heart Failure.” In Journal of Cardiac Failure, 28:S3–S3, 2022.
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  - Arps, Kelly, Jayanth Doss, Kelly V. Geiger, Adam DeVore, Ravi Karra, Han W. Kim, Piccini Jonathan P. Sr, Sean Pokorney, and Albert Y. Sun. “TIME TO RELAPSE AFTER WEANING IMMUNE SUPPRESSIVE THERAPY IN CARDIAC SARCOIDOSIS: A SINGLE-CENTER EXPERIENCE.” In Journal of the American College of Cardiology, 79:250–250, 2022.
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  - Karpurapu, A., A. Krekorian, Y. Tian, L. M. Collins, R. Karra, A. D. Franklin, and B. O. Mainsah. “Evaluating the effect of longitudinal dose and INR data on maintenance warfarin dose predictions.” In Bhi 2021 2021 Ieee Embs International Conference on Biomedical and Health Informatics, Proceedings, 2021. https://doi.org/10.1109/BHI50953.2021.9508510.
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  - Chen, X. J., L. M. Collins, P. A. Patel, R. Karra, and B. O. Mainsah. “Heart Sound Analysis in Individuals Supported with Left Ventricular Assist Device: A First Look.” In Computing in Cardiology, Vol. 2020-September, 2020. https://doi.org/10.22489/CinC.2020.080.
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  - Felker, G Michael, John McMurray, John Cleland, Christopher O’Connor, John Teerlink, Adriaan Voors, Ninian Lang, et al. “HEMODYNAMIC EFFECTS OF NITROXYL DONOR BMS-986231 COMPARED TO NITROGLYCERIN OR PLACEBO IN PATIENTS WITH CHRONIC HEART FAILURE-A RANDOMIZED DOUBLE-BLIND CROSSOVER TRIAL.” In Journal of the American College of Cardiology, 75:850–850. ELSEVIER SCIENCE INC, 2020.
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  - Mandawat, Aditya, Anant Mandawat, Priya Vijayvargiya, and Ravi Karra. “Reduced Gastrointestinal Bleeding in Patients With Improved Left Ventricular Function After Left Ventricular Assist Device Implantation.” In Circulation, Vol. 138, 2018.
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  - Van Kirk, Jenny, and Ravi Karra. “Recovery of Ventricular Function is a Heterogeneous Phenotype in Patients With Chronic Heart Failure.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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  - Goldman, J. A., G. Kuzu, N. Lee, J. Karasik, M. Gemberling, R. Karra, A. Dickson, M. Y. Tolstorukov, and K. D. Poss. “Deciphering Heart Regeneration by Histone Exchange Profiling.” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.
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  - Karra, Ravi, Anne Knecht, and Kenneth D. Poss. “NF-kappa B Activity is Required for Heart Regeneration.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.
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  - Hauser, E. R., S. Gregory, D. Seo, A. Dobra, E. Iversen, R. Karra, C. Haynes, et al. “Convergence of genome-wide expression analysis and genome-wide linkage analysis identifies candidate genes for atherosclerosis.” In Circulation, 110:823–823. LIPPINCOTT WILLIAMS & WILKINS, 2004.
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  - Seo, D., R. Karra, T. Wang, H. Dressman, M. West, J. Nevins, and P. Goldschmidt. “Genomic convergence in the study of human and mouse atherosclerosis.” In Circulation, 108:282–282. LIPPINCOTT WILLIAMS & WILKINS, 2003.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses