Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Duke University School of Medicine 2005
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2013 - 2015
• Research
• 

  Selected Grants

  • Oral Doses of MYK-491 in Patients with Stable Heart Failure awarded by MyoKardia, Inc. 2018 - 2019
  • BMS-986231_Heart Failure awarded by Bristol-Myers Squibb Company 2018
  • Biomarkers of Heart Regeneration awarded by National Institutes of Health 2013 - 2018
  • IW-1973 Caplet awarded by Ironwood Pharmaceuticals, Inc. 2017 - 2018
  • MedImmune MED12C02 Coronary Artery Disease awarded by MedImmune, Inc. 2015 - 2016
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Karra, R, and Kaye, KS. "Mediastinitis." In Clinical Infectious Disease, Second Edition, 268-272. January 1, 2015.  Full Text

  • Journal Articles

    • Karra, R, Walter, AO, and Wu, SM. "The relationship between cardiac endothelium and fibroblasts: it's complicated." Journal of Clinical Investigation 127, no. 8 (August 2017): 2892-2894.  Full Text
    • Goldman, JA, Kuzu, G, Lee, N, Karasik, J, Gemberling, M, Foglia, MJ, Karra, R, Dickson, AL, Sun, F, Tolstorukov, MY, and Poss, KD. "Resolving Heart Regeneration by Replacement Histone Profiling." Developmental cell 40, no. 4 (February 2017): 392-404.e5.  Full Text
    • Karra, R, and Poss, KD. "Redirecting cardiac growth mechanisms for therapeutic regeneration." The Journal of clinical investigation 127, no. 2 (February 2017): 427-436. (Review)  Full Text
    • Kang, J, Hu, J, Karra, R, Dickson, AL, Tornini, VA, Nachtrab, G, Gemberling, M, Goldman, JA, Black, BL, and Poss, KD. "Modulation of tissue repair by regeneration enhancer elements." Nature 532, no. 7598 (April 6, 2016): 201-206.  Full Text
    • Cao, J, Navis, A, Cox, BD, Dickson, AL, Gemberling, M, Karra, R, Bagnat, M, and Poss, KD. "Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration." Development (Cambridge, England) 143, no. 2 (January 2016): 232-243.  Full Text
    • Karra, R, Knecht, AK, Kikuchi, K, and Poss, KD. "Myocardial NF-κB activation is essential for zebrafish heart regeneration." Proceedings of the National Academy of Sciences of the United States of America 112, no. 43 (October 15, 2015): 13255-13260.  Full Text
    • Kang, J, Karra, R, and Poss, KD. "Back in Black." Developmental cell 33, no. 6 (June 2015): 623-624.  Full Text
    • Gemberling, M, Karra, R, Dickson, AL, and Poss, KD. "Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish." eLife 4 (April 2015).  Full Text  Open Access Copy
    • Wang, J, Karra, R, Dickson, AL, and Poss, KD. "Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration." Dev Biol 382, no. 2 (October 15, 2013): 427-435.  Full Text  Link to Item
    • Fang, Y, Gupta, V, Karra, R, Holdway, JE, Kikuchi, K, and Poss, KD. "Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration." Proc Natl Acad Sci U S A 110, no. 33 (August 13, 2013): 13416-13421.  Full Text  Link to Item
    • Gupta, V, Gemberling, M, Karra, R, Rosenfeld, GE, Evans, T, and Poss, KD. "An injury-responsive gata4 program shapes the zebrafish cardiac ventricle." Curr Biol 23, no. 13 (July 8, 2013): 1221-1227.  Full Text  Link to Item
    • Gregoire, S, Karra, R, Passer, D, Deutsch, M-A, Krane, M, Feistritzer, R, Sturzu, A, Domian, I, Saga, Y, and Wu, SM. "Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation." Circulation research 112, no. 6 (March 2013): 900-910.  Full Text
    • Gupta, V, Gemberling, M, Karra, R, Rosenfeld, GE, Evans, T, and Poss, KD. "An injury-responsive gata4 program shapes the zebrafish cardiac ventricle." Current Biology 23, no. 13 (2013): 1221-1227.  Full Text
    • Chen, JX, Krane, M, Deutsch, M-A, Wang, L, Rav-Acha, M, Gregoire, S, Engels, MC, Rajarajan, K, Karra, R, Abel, ED, Wu, JC, Milan, D, and Wu, SM. "Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5." Circulation research 111, no. 1 (June 2012): 50-55.  Full Text
    • Chen, JX, Krane, M, Deutsch, M-A, Wang, L, Rav-Acha, M, Gregoire, S, Engels, MC, Rajarajan, K, Karra, R, Abel, ED, Wu, JC, Milan, D, and Wu, SM. "Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5." Circulation research 111, no. 1 (2012): 50-55.  Full Text
    • Martin, SS, Karra, R, and Mark, DB. "Pheochromocytoma presenting as fever of unknown origin." The American journal of medicine 124, no. 2 (February 2011): e5-e6. (Letter)  Full Text
    • Kaye, KS, and Karra, R. "Mediastinitis." (January 1, 2010): 279-284. (Chapter)  Full Text
    • Karra, R, and Wu, SM. "Multipotent stem cells in cardiac regenerative therapy." Regenerative medicine 3, no. 2 (March 2008): 189-198.  Full Text
    • Liu, Y-H, Karra, R, and Wu, SM. "Cardiovascular Stem Cells in Regenerative Medicine: Ready for Prime Time?." Drug discovery today. Therapeutic strategies 5, no. 4 (January 2008): 201-207.  Full Text
    • Karra, R, McDermott, L, Connelly, S, Smith, P, Sexton, DJ, and Kaye, KS. "Risk factors for 1-year mortality after postoperative mediastinitis." J Thorac Cardiovasc Surg 132, no. 3 (September 2006): 537-543.  Full Text  Link to Item
    • Karra, R, Vemullapalli, S, Dong, C, Herderick, EE, Song, X, Slosek, K, Nevins, JR, West, M, Goldschmidt-Clermont, PJ, and Seo, D. "Molecular evidence for arterial repair in atherosclerosis." Proc Natl Acad Sci U S A 102, no. 46 (November 15, 2005): 16789-16794.  Full Text  Link to Item

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