2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.
Journal Article (Journal Article)
We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.
Full Text
Duke Authors
Cited Authors
- Leahy, DJ; Aukhil, I; Erickson, HP
Published Date
- January 12, 1996
Published In
Volume / Issue
- 84 / 1
Start / End Page
- 155 - 164
PubMed ID
- 8548820
International Standard Serial Number (ISSN)
- 0092-8674
Digital Object Identifier (DOI)
- 10.1016/s0092-8674(00)81002-8
Language
- eng
Conference Location
- United States