Overview
Recent research has been on cytoskeleton (eukaryotes and bacteria); a skirmish to debunk the irisin story; a reinterpretation of proposed multivalent binders of the coronavirus spike protein. I have also published an ebook on "Principles of Protein-Protein Association" suitable for a course module or individual learning.
Current Appointments & Affiliations
James B. Duke Distinguished Professor Emeritus of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Professor Emeritus of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Recent Publications
Recently Designed Multivalent Spike Binders Cannot Bind Multivalently─How Do They Achieve Enhanced Avidity to SARS-CoV-2?
Journal Article Biochemistry · January 17, 2023 The trimeric spike protein of SARS-CoV-2 has been targeted by antibody mimics that bind near or at the receptor-binding domain to neutralize the virus. Several independent studies have reported enhanced binding avidity for dimers and trimers, where binding ... Full text Open Access Link to item CiteFtsZ at mid-cell is essential in Escherichia coli until the late stage of constriction.
Journal Article Microbiology (Reading) · June 2022 There has been recent debate as to the source of constriction force during cell division. FtsZ can generate a constriction force on tubular membranes in vitro, suggesting it may generate the constriction force in vivo. However, another study showed that mu ... Full text Open Access Link to item CiteRecent Grants
Organization and Function of Cellular Structure
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020Differentiation Induced Changes in Centrosomes and Microtubule Organization
ResearchCollaborator · Awarded by National Institutes of Health · 2014 - 2019Structure and Assembly Dynamics of FtsZ
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2019View All Grants
Education, Training & Certifications
Johns Hopkins University ·
1968
Ph.D.