Coexistence of localized Langerhans cell histiocytosis and cutaneous Rosai-Dorfman disease.
Journal Article (Journal Article)
Rosai-Dorfman disease (RDD; sinus histiocytosis with massive lymphadenopathy) and Langerhans cell histiocytosis (LCH) are two different yet pathogenetically related histiocytic disorders. While systemic and localized forms have been identified in both diseases, each has its own characteristic histological, immunohistochemical and ultrastructural profile. Rarely, either RDD or LCH can also occur in the context of certain malignant neoplasms. However, the coexistence of RDD and LCH has never been described. We report a case of cutaneous RDD in which a focus of LCH was found. Clinical and laboratory examinations revealed no evidence of extracutaneous involvement of RDD or LCH. We believe that this is the first report of such a coexistence, and the possible pathogenesis is discussed.
Full Text
Duke Authors
Cited Authors
- Wang, K-H; Cheng, C-J; Hu, C-H; Lee, W-R
Published Date
- October 2002
Published In
Volume / Issue
- 147 / 4
Start / End Page
- 770 - 774
PubMed ID
- 12366428
International Standard Serial Number (ISSN)
- 0007-0963
Digital Object Identifier (DOI)
- 10.1046/j.1365-2133.2002.04879.x
Language
- eng
Conference Location
- England