Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41.

Journal Article (Journal Article)

Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical N-linked glycosylation sequences. One altered site produced a severe impairment of viral infectivity, which raises the possibility that N-linked sugars at this site may have an important role in the human immunodeficiency virus type 1 life cycle.

Full Text

Duke Authors

Cited Authors

  • Lee, WR; Yu, XF; Syu, WJ; Essex, M; Lee, TH

Published Date

  • March 1992

Published In

Volume / Issue

  • 66 / 3

Start / End Page

  • 1799 - 1803

PubMed ID

  • 1738209

Pubmed Central ID

  • PMC240944

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/JVI.66.3.1799-1803.1992

Language

  • eng

Conference Location

  • United States