Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41.
Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical N-linked glycosylation sequences. One altered site produced a severe impairment of viral infectivity, which raises the possibility that N-linked sugars at this site may have an important role in the human immunodeficiency virus type 1 life cycle.
Lee, WR; Yu, XF; Syu, WJ; Essex, M; Lee, TH
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