Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41.
Publication
, Journal Article
Lee, WR; Yu, XF; Syu, WJ; Essex, M; Lee, TH
Published in: J Virol
March 1992
Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical N-linked glycosylation sequences. One altered site produced a severe impairment of viral infectivity, which raises the possibility that N-linked sugars at this site may have an important role in the human immunodeficiency virus type 1 life cycle.
Duke Scholars
Published In
J Virol
DOI
ISSN
0022-538X
Publication Date
March 1992
Volume
66
Issue
3
Start / End Page
1799 / 1803
Location
United States
Related Subject Headings
- Virology
- Structure-Activity Relationship
- Oligodeoxyribonucleotides
- Molecular Sequence Data
- Membrane Glycoproteins
- In Vitro Techniques
- Humans
- HIV-1
- HIV Envelope Protein gp41
- Glycosylation
Citation
APA
Chicago
ICMJE
MLA
NLM
Lee, W. R., Yu, X. F., Syu, W. J., Essex, M., & Lee, T. H. (1992). Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41. J Virol, 66(3), 1799–1803. https://doi.org/10.1128/JVI.66.3.1799-1803.1992
Lee, W. R., X. F. Yu, W. J. Syu, M. Essex, and T. H. Lee. “Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41.” J Virol 66, no. 3 (March 1992): 1799–1803. https://doi.org/10.1128/JVI.66.3.1799-1803.1992.
Lee WR, Yu XF, Syu WJ, Essex M, Lee TH. Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41. J Virol. 1992 Mar;66(3):1799–803.
Lee, W. R., et al. “Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41.” J Virol, vol. 66, no. 3, Mar. 1992, pp. 1799–803. Pubmed, doi:10.1128/JVI.66.3.1799-1803.1992.
Lee WR, Yu XF, Syu WJ, Essex M, Lee TH. Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41. J Virol. 1992 Mar;66(3):1799–1803.
Published In
J Virol
DOI
ISSN
0022-538X
Publication Date
March 1992
Volume
66
Issue
3
Start / End Page
1799 / 1803
Location
United States
Related Subject Headings
- Virology
- Structure-Activity Relationship
- Oligodeoxyribonucleotides
- Molecular Sequence Data
- Membrane Glycoproteins
- In Vitro Techniques
- Humans
- HIV-1
- HIV Envelope Protein gp41
- Glycosylation