Hypercalcemia in patients with advanced chronic renal failure not yet requiring dialysis.


Journal Article

Six patients with progressive chronic renal failure not yet requiring dialysis and not consuming supplemental calcium or vitamin D developed hypercalcemia. Three had proven and 1 suspected tertiary hyperparathyroidism, 1 parathyroid carcinoma and 1 aplastic bone. None of the 3 patients who underwent bone biopsy had heavy bone aluminum staining. The patients with proven parathyroid-mediated hypercalcemia had marked elevation of C-terminal parathyroid hormone and alkaline phosphatase values and, when performed, radiographs consistent with osteitis fibrosa. When these findings are absent or the diagnosis is otherwise uncertain, a bone biopsy may provide a definitive diagnosis and guide management.

Full Text

Duke Authors

Cited Authors

  • Greenberg, A; Piraino, BM; Bruns, FJ

Published Date

  • January 1989

Published In

Volume / Issue

  • 9 / 3

Start / End Page

  • 205 - 210

PubMed ID

  • 2757079

Pubmed Central ID

  • 2757079

Electronic International Standard Serial Number (EISSN)

  • 1421-9670

International Standard Serial Number (ISSN)

  • 0250-8095

Digital Object Identifier (DOI)

  • 10.1159/000167966


  • eng