Skip to main content
Journal cover image

Landau-Kleffner syndrome: consistent response to repeated intravenous gamma-globulin doses: a case report.

Publication ,  Journal Article
Fayad, MN; Choueiri, R; Mikati, M
Published in: Epilepsia
April 1997

PURPOSE: Although several treatments have been tried for Landau-Kleffner syndrome (LKS) too many patients are refractory to known therapies. We report an 8-year-old girl who failed other therapies but who had a consistent response after treatment with intravenous (i.v.) gamma-globulin. METHODS: We monitored the girl from the age of 6 years, when she presented with a 6-month history of loss of language with normal hearing, normal brain magnetic resonance imaging (MRI), increased cerebrospinal fluid (CSF) IgG index, and an EEG showing almost continuous, predominantly left-sided spike- and slow-wave complexes. She had no clinical seizures and did not respond to consecutive trials of valproate (VPA), clonazepam (CZP), prednisone, and carbamazepine (CBZ). She received three courses of intravenous (i.v.) gamma-globulin; after each course, clinical and electrographic improvement lasted a few months. After each of the initial two courses, clinical improvement lasted 3-4 months but was followed by recurrence of the spikes on the EEG and by speech deterioration. RESULTS: However, her last remission has been continuous for the past 16 months. Her CSF IgG index became normal after the first i.v. gamma-globulin infusion. CONCLUSIONS: Based on our experience with this patient and on other investigators' experience, we believe that further research into immunologic mechanisms and therapies of this syndrome are warranted.

Duke Scholars

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

April 1997

Volume

38

Issue

4

Start / End Page

489 / 494

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Landau-Kleffner Syndrome
  • Immunoglobulins, Intravenous
  • Humans
  • Female
  • Electroencephalography
  • Child
  • Cerebral Cortex
  • Anticonvulsants
  • 3209 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fayad, M. N., Choueiri, R., & Mikati, M. (1997). Landau-Kleffner syndrome: consistent response to repeated intravenous gamma-globulin doses: a case report. Epilepsia, 38(4), 489–494. https://doi.org/10.1111/j.1528-1157.1997.tb01740.x
Fayad, M. N., R. Choueiri, and M. Mikati. “Landau-Kleffner syndrome: consistent response to repeated intravenous gamma-globulin doses: a case report.Epilepsia 38, no. 4 (April 1997): 489–94. https://doi.org/10.1111/j.1528-1157.1997.tb01740.x.
Fayad, M. N., et al. “Landau-Kleffner syndrome: consistent response to repeated intravenous gamma-globulin doses: a case report.Epilepsia, vol. 38, no. 4, Apr. 1997, pp. 489–94. Pubmed, doi:10.1111/j.1528-1157.1997.tb01740.x.
Journal cover image

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

April 1997

Volume

38

Issue

4

Start / End Page

489 / 494

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Landau-Kleffner Syndrome
  • Immunoglobulins, Intravenous
  • Humans
  • Female
  • Electroencephalography
  • Child
  • Cerebral Cortex
  • Anticonvulsants
  • 3209 Neurosciences