Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.

Published

Journal Article

Children who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans.

Full Text

Duke Authors

Cited Authors

  • Neill, JC; Liu, Z; Mikati, M; Holmes, GL

Published Date

  • November 2005

Published In

Volume / Issue

  • 84 / 3

Start / End Page

  • 357 - 370

PubMed ID

  • 16596970

Pubmed Central ID

  • 16596970

Electronic International Standard Serial Number (EISSN)

  • 1938-3711

International Standard Serial Number (ISSN)

  • 0022-5002

Digital Object Identifier (DOI)

  • 10.1901/jeab.2005.84-04

Language

  • eng