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Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.

Publication ,  Journal Article
Neill, JC; Liu, Z; Mikati, M; Holmes, GL
Published in: J Exp Anal Behav
November 2005

Children who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans.

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Published In

J Exp Anal Behav

DOI

ISSN

0022-5002

Publication Date

November 2005

Volume

84

Issue

3

Start / End Page

357 / 370

Location

United States

Related Subject Headings

  • Status Epilepticus
  • Sound Localization
  • Reaction Time
  • Rats, Sprague-Dawley
  • Rats
  • Psychomotor Performance
  • Pilocarpine
  • Neurons
  • Muscarinic Agonists
  • Male
 

Citation

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Neill, J. C., Liu, Z., Mikati, M., & Holmes, G. L. (2005). Pilocarpine seizures cause age-dependent impairment in auditory location discrimination. J Exp Anal Behav, 84(3), 357–370. https://doi.org/10.1901/jeab.2005.84-04
Neill, John C., Zhao Liu, Mohammad Mikati, and Gregory L. Holmes. “Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.J Exp Anal Behav 84, no. 3 (November 2005): 357–70. https://doi.org/10.1901/jeab.2005.84-04.
Neill JC, Liu Z, Mikati M, Holmes GL. Pilocarpine seizures cause age-dependent impairment in auditory location discrimination. J Exp Anal Behav. 2005 Nov;84(3):357–70.
Neill, John C., et al. “Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.J Exp Anal Behav, vol. 84, no. 3, Nov. 2005, pp. 357–70. Pubmed, doi:10.1901/jeab.2005.84-04.
Neill JC, Liu Z, Mikati M, Holmes GL. Pilocarpine seizures cause age-dependent impairment in auditory location discrimination. J Exp Anal Behav. 2005 Nov;84(3):357–370.

Published In

J Exp Anal Behav

DOI

ISSN

0022-5002

Publication Date

November 2005

Volume

84

Issue

3

Start / End Page

357 / 370

Location

United States

Related Subject Headings

  • Status Epilepticus
  • Sound Localization
  • Reaction Time
  • Rats, Sprague-Dawley
  • Rats
  • Psychomotor Performance
  • Pilocarpine
  • Neurons
  • Muscarinic Agonists
  • Male