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Genetic studies in neural tube defects. NTD Collaborative Group.

Publication ,  Journal Article
Melvin, EC; George, TM; Worley, G; Franklin, A; Mackey, J; Viles, K; Shah, N; Drake, CR; Enterline, DS; McLone, D; Nye, J; Oakes, WJ; Brei, T ...
Published in: Pediatr Neurosurg
January 2000

Neural tube defects (NTD) are one of the most common birth defects and are caused by both environmental and genetic factors. The approach to identifying the genes predisposing to NTD, through linkage analysis and candidate gene analysis, is reviewed along with characteristics of a large, nationally ascertained cohort of families. Results from specific assessments of p53, PAX3 and MTHFR failed to suggest that these genes play a major role in NTD development in these families. Advances in genetic laboratory and statistical techniques have made this a prime opportunity for investigation into the causes of complex disorders, such as NTD. However, traditional approaches may prove to be challenging due to the difficulty of ascertaining samplable multiplex families.

Duke Scholars

Published In

Pediatr Neurosurg

DOI

ISSN

1016-2291

Publication Date

January 2000

Volume

32

Issue

1

Start / End Page

1 / 9

Location

Switzerland

Related Subject Headings

  • Risk Factors
  • Neurology & Neurosurgery
  • Neural Tube Defects
  • Humans
  • Genetic Techniques
  • Genetic Linkage
  • Folic Acid
  • Cohort Studies
  • Chromosome Disorders
  • Chromosome Aberrations
 

Citation

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MLA
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Melvin, E. C., George, T. M., Worley, G., Franklin, A., Mackey, J., Viles, K., … Speer, M. C. (2000). Genetic studies in neural tube defects. NTD Collaborative Group. Pediatr Neurosurg, 32(1), 1–9. https://doi.org/10.1159/000028889
Melvin, E. C., T. M. George, G. Worley, A. Franklin, J. Mackey, K. Viles, N. Shah, et al. “Genetic studies in neural tube defects. NTD Collaborative Group.Pediatr Neurosurg 32, no. 1 (January 2000): 1–9. https://doi.org/10.1159/000028889.
Melvin EC, George TM, Worley G, Franklin A, Mackey J, Viles K, et al. Genetic studies in neural tube defects. NTD Collaborative Group. Pediatr Neurosurg. 2000 Jan;32(1):1–9.
Melvin, E. C., et al. “Genetic studies in neural tube defects. NTD Collaborative Group.Pediatr Neurosurg, vol. 32, no. 1, Jan. 2000, pp. 1–9. Pubmed, doi:10.1159/000028889.
Melvin EC, George TM, Worley G, Franklin A, Mackey J, Viles K, Shah N, Drake CR, Enterline DS, McLone D, Nye J, Oakes WJ, McLaughlin C, Walker ML, Peterson P, Brei T, Buran C, Aben J, Ohm B, Bermans I, Qumsiyeh M, Vance J, Pericak-Vance MA, Speer MC. Genetic studies in neural tube defects. NTD Collaborative Group. Pediatr Neurosurg. 2000 Jan;32(1):1–9.
Journal cover image

Published In

Pediatr Neurosurg

DOI

ISSN

1016-2291

Publication Date

January 2000

Volume

32

Issue

1

Start / End Page

1 / 9

Location

Switzerland

Related Subject Headings

  • Risk Factors
  • Neurology & Neurosurgery
  • Neural Tube Defects
  • Humans
  • Genetic Techniques
  • Genetic Linkage
  • Folic Acid
  • Cohort Studies
  • Chromosome Disorders
  • Chromosome Aberrations