Overview
Dr. Gordon Worley specializes in Neurodevelopmental Disabilities, a sub-specialty of Pediatrics focusing on the management of the medical problems of children with physical disabilities. The principal diagnoses he treats are cerebral palsy, spina bifida, and Down syndrome. HIs research pertains to clinical problems of children with these conditions. Current research interests include genetic factors influencing outcomes of Extremely Low Birth Weight Infants using analyses of a large data set; comparison of outcomes of prenatal (in utero) surgery vs postnatal for lesion closure in meningomyelocele using the National Spina Bifida Patient Registry; Down Syndrome Disintegrative Disorder; and associations of ADHD with high risk sexual behaviors using analyses of a large data set.
Current Appointments & Affiliations
Professor Emeritus of Pediatrics
·
2017 - Present
Pediatrics, Neurology,
Pediatrics
Recent Publications
Neuroimaging abnormalities associated with immunotherapy responsiveness in Down syndrome regression disorder.
Journal Article Ann Clin Transl Neurol · April 2024 OBJECTIVE: To determine the prevalence of neuroimaging abnormalities in individuals with Down syndrome regression disorder (DSRD) and evaluate if neuroimaging abnormalities were predictive of therapeutic responses. METHODS: A multicenter, retrospective, ca ... Full text Link to item CiteAn exploratory study of plasma ceramides in comorbidities in Down syndrome.
Journal Article Am J Med Genet A · September 2023 Plasma ceramide levels (henceforth, "ceramides") are biomarkers of some diseases that are comorbidities of Down syndrome (DS). We sought to determine if comorbidities in DS were associated with ceramides, studying a convenience cohort of 35 study participa ... Full text Link to item CiteImmunotherapy responsiveness and risk of relapse in Down syndrome regression disorder.
Journal Article Transl Psychiatry · August 8, 2023 Down syndrome regression disorder (DSRD) is a clinical symptom cluster consisting of neuropsychiatric regression without an identifiable cause. This study evaluated the clinical effectiveness of IVIg and evaluated clinical characteristics associated with r ... Full text Link to item CiteRecent Grants
National Spina Bifida Patient Registry - Duke Clinic Demonstration Project
ResearchCo Investigator · Awarded by Centers for Disease Control and Prevention · 2011 - 2014View All Grants
Education, Training & Certifications
Harvard University ·
1973
M.D.
Dartmouth College ·
1971
B.M.S.
University of Wisconsin, Madison ·
1969
B.A.