Future directions in regional treatment strategies for melanoma and sarcoma.

Journal Article (Journal Article;Review)

Hyperthermic isolated limb perfusion (HILP) with melphalan and more recently isolated limb infusion (ILI) with melphalan +/- dactinomycin are common treatment modalities for both in-transit melanoma of the extremity and advanced extremity sarcoma. In order to further optimize treatment, future research should focus on selection of appropriate patients, verification of a technique that produces consistent results while maintaining acceptable toxicity, and development of novel strategies and agents. Development of these novel agents and strategies has potential to not only improve the efficacy of regional chemotherapy but may also help guide future strategies for systemic treatment.

Full Text

Duke Authors

Cited Authors

  • Beasley, GM; Ross, MI; Tyler, DS

Published Date

  • May 2008

Published In

Volume / Issue

  • 24 / 3

Start / End Page

  • 301 - 309

PubMed ID

  • 18393007

International Standard Serial Number (ISSN)

  • 0265-6736

Digital Object Identifier (DOI)

  • 10.1080/02656730701827573


  • eng

Conference Location

  • England