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Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies.

Publication ,  Journal Article
Hoyo, C; Murphy, SK; Jirtle, RL
Published in: J Epidemiol Community Health
September 2009

In the etiologic investigation of complex diseases and neuro-developmental disorders, the interaction of genetic factors and the environment have been evaluated by comparing disease risk as a function of environmental exposure in individuals who carry genetic variants of interest. While advances in technology have improved classification of genetic variant data, methods to ascertain environmental exposures remain largely underdeveloped. In this editorial, we discuss how mitotically heritable epigenetic marks in imprint regulatory elements may potentially serve as genome-wide biosensors of exposure, thereby reducing exposure misclassification, especially in studies evaluating the early origins of adult disease. Development of epigenetic biosensors for exposure monitoring will require a concerted effort in not only demonstrating that they are a stable record of past exposures, but also that the epigenetic marks are causally related to exposure.

Duke Scholars

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Published In

J Epidemiol Community Health

DOI

EISSN

1470-2738

Publication Date

September 2009

Volume

63

Issue

9

Start / End Page

683 / 684

Location

England

Related Subject Headings

  • Phenotype
  • Mental Recall
  • Humans
  • Health Behavior
  • Genotype
  • Genomic Imprinting
  • Folic Acid
  • Epigenesis, Genetic
  • Epidemiology
  • Epidemiologic Studies
 

Citation

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Hoyo, C., Murphy, S. K., & Jirtle, R. L. (2009). Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies. J Epidemiol Community Health, 63(9), 683–684. https://doi.org/10.1136/jech.2009.090803
Hoyo, Cathrine, Susan K. Murphy, and Randy L. Jirtle. “Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies.J Epidemiol Community Health 63, no. 9 (September 2009): 683–84. https://doi.org/10.1136/jech.2009.090803.
Hoyo C, Murphy SK, Jirtle RL. Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies. J Epidemiol Community Health. 2009 Sep;63(9):683–4.
Hoyo, Cathrine, et al. “Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies.J Epidemiol Community Health, vol. 63, no. 9, Sept. 2009, pp. 683–84. Pubmed, doi:10.1136/jech.2009.090803.
Hoyo C, Murphy SK, Jirtle RL. Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies. J Epidemiol Community Health. 2009 Sep;63(9):683–684.

Published In

J Epidemiol Community Health

DOI

EISSN

1470-2738

Publication Date

September 2009

Volume

63

Issue

9

Start / End Page

683 / 684

Location

England

Related Subject Headings

  • Phenotype
  • Mental Recall
  • Humans
  • Health Behavior
  • Genotype
  • Genomic Imprinting
  • Folic Acid
  • Epigenesis, Genetic
  • Epidemiology
  • Epidemiologic Studies