Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.

Journal Article (Journal Article)

Neurodegenerative diseases like Alzheimer's and Parkinson's disease are associated with elevated levels of iron, copper, and zinc and consequentially high levels of oxidative stress. Given the multifactorial nature of these diseases, it is becoming evident that the next generation of therapies must have multiple functions to combat multiple mechanisms of disease progression. Metal-chelating agents provide one such function as an intervention for ameliorating metal-associated damage in degenerative diseases. Targeting chelators to adjust localized metal imbalances in the brain, however, presents significant challenges. In this perspective, we focus on some noteworthy advances in the area of multifunctional metal chelators as potential therapeutic agents for neurodegenerative diseases. In addition to metal chelating ability, these agents also contain features designed to improve their uptake across the blood-brain barrier, increase their selectivity for metals in damage-prone environments, increase antioxidant capabilities, lower Abeta peptide aggregation, or inhibit disease-associated enzymes such as monoamine oxidase and acetylcholinesterase.

Full Text

Duke Authors

Cited Authors

  • Perez, LR; Franz, KJ

Published Date

  • March 2010

Published In

Volume / Issue

  • 39 / 9

Start / End Page

  • 2177 - 2187

PubMed ID

  • 20162187

Pubmed Central ID

  • PMC2860397

Electronic International Standard Serial Number (EISSN)

  • 1477-9234

International Standard Serial Number (ISSN)

  • 1477-9226

Digital Object Identifier (DOI)

  • 10.1039/b919237a


  • eng