The genetics of inbreeding depression.

Published

Journal Article (Review)

Inbreeding depression - the reduced survival and fertility of offspring of related individuals - occurs in wild animal and plant populations as well as in humans, indicating that genetic variation in fitness traits exists in natural populations. Inbreeding depression is important in the evolution of outcrossing mating systems and, because intercrossing inbred strains improves yield (heterosis), which is important in crop breeding, the genetic basis of these effects has been debated since the early twentieth century. Classical genetic studies and modern molecular evolutionary approaches now suggest that inbreeding depression and heterosis are predominantly caused by the presence of recessive deleterious mutations in populations.

Full Text

Duke Authors

Cited Authors

  • Charlesworth, D; Willis, JH

Published Date

  • November 2009

Published In

Volume / Issue

  • 10 / 11

Start / End Page

  • 783 - 796

PubMed ID

  • 19834483

Pubmed Central ID

  • 19834483

Electronic International Standard Serial Number (EISSN)

  • 1471-0064

International Standard Serial Number (ISSN)

  • 1471-0056

Digital Object Identifier (DOI)

  • 10.1038/nrg2664

Language

  • eng