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Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer.

Publication ,  Journal Article
Kim, SJ; Rabbani, ZN; Dong, F; Vollmer, RT; Schreiber, E-G; Dewhirst, MW; Vujaskovic, Z; Kelley, MJ
Published in: Med Oncol
March 2010

PURPOSE: The prognostic significance of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) expression remains unestablished, although EGFR and COX-2 are frequently overexpressed in non-small cell lung cancer (NSCLC). Considering the importance of EGFR activation after ligand binding, however, the expression of phosphorylated EGFR (p-EGFR) may have more significance in predicting tumor aggressiveness in NSCLC than either EGFR or COX-2 expression. PATIENTS AND METHODS: We studied the relationships between p-EGFR, EGFR, and COX-2 overexpression and examined their association with prognosis in localized NSCLC. The expression of p-EGFR, EGFR, and COX-2 was studied by immunohistochemistry in 77 surgically-resected stage I/II NSCLC cases. EGFR mutational status was determined by sequencing exons 18-21. Correlation of expression with clinical outcome and other biomarkers, including Ki-67 and microvessel density (MVD), was also examined. RESULTS: Out of the 77 patients, EGFR overexpression was observed in 37 (48.1%), p-EGFR expression was found in 22 (28.6%), and COX-2 overexpression was seen in 45 (58.4%). Expression of p-EGFR was associated with COX-2 overexpression (P = 0.047), but not EGFR overexpression or high Ki-67 (P = 0.087 and P = 0.092, respectively). COX-2 overexpression was significantly associated with high Ki-67 (P = 0.011). Expression of p-EGFR correlated with lower disease-free survival (P = 0.045), but not overall survival. Neither EGFR nor COX-2 overexpression was associated with prognosis. CONCLUSION: p-EGFR appears to be a better indicator for lower disease-free survival than EGFR overexpression itself in localized NSCLC. Pathways other than EGFR activation may influence COX-2 overexpression.

Duke Scholars

Published In

Med Oncol

DOI

EISSN

1559-131X

Publication Date

March 2010

Volume

27

Issue

1

Start / End Page

91 / 97

Location

United States

Related Subject Headings

  • Phosphorylation
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Middle Aged
  • Microvessels
  • Male
  • Lung Neoplasms
  • Ki-67 Antigen
  • Immunohistochemistry
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kim, S. J., Rabbani, Z. N., Dong, F., Vollmer, R. T., Schreiber, E.-G., Dewhirst, M. W., … Kelley, M. J. (2010). Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer. Med Oncol, 27(1), 91–97. https://doi.org/10.1007/s12032-009-9178-z
Kim, Seok Jin, Zahid N. Rabbani, Fan Dong, Robin T. Vollmer, Ernst-Gilbert Schreiber, Mark W. Dewhirst, Zeljko Vujaskovic, and Michael J. Kelley. “Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer.Med Oncol 27, no. 1 (March 2010): 91–97. https://doi.org/10.1007/s12032-009-9178-z.
Kim SJ, Rabbani ZN, Dong F, Vollmer RT, Schreiber E-G, Dewhirst MW, et al. Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer. Med Oncol. 2010 Mar;27(1):91–7.
Kim, Seok Jin, et al. “Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer.Med Oncol, vol. 27, no. 1, Mar. 2010, pp. 91–97. Pubmed, doi:10.1007/s12032-009-9178-z.
Kim SJ, Rabbani ZN, Dong F, Vollmer RT, Schreiber E-G, Dewhirst MW, Vujaskovic Z, Kelley MJ. Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer. Med Oncol. 2010 Mar;27(1):91–97.
Journal cover image

Published In

Med Oncol

DOI

EISSN

1559-131X

Publication Date

March 2010

Volume

27

Issue

1

Start / End Page

91 / 97

Location

United States

Related Subject Headings

  • Phosphorylation
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Middle Aged
  • Microvessels
  • Male
  • Lung Neoplasms
  • Ki-67 Antigen
  • Immunohistochemistry
  • Humans