Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors.
Publication
, Journal Article
Vishwanath, K; Yuan, H; Barry, WT; Dewhirst, MW; Ramanujam, N
Published in: Neoplasia
September 2009
The feasibility of using quantitative diffuse reflectance spectroscopy to longitudinally monitor physiological response to cancer therapy was evaluated in a preclinical model. This study included two groups of nude mice bearing 4T1 flank tumors (N = 50), half of which were treated with a maximum tolerated dose of doxorubicin (DOX). Diffuse reflectance spectra were collected from tumors during a period of 2 weeks using a fiber-optic probe coupled to a spectrometer. These spectra were quantified using an inverse scalable Monte Carlo model of light transport in tissue to extract the concentrations of oxygenated, deoxygenated hemoglobin (dHb), and a wavelength mean reduced scattering coefficient (
Duke Scholars
Published In
Neoplasia
DOI
EISSN
1476-5586
Publication Date
September 2009
Volume
11
Issue
9
Start / End Page
889 / 900
Location
United States
Related Subject Headings
- Spectrophotometry
- Oxygen
- Oncology & Carcinogenesis
- Monte Carlo Method
- Mice, Nude
- Mice
- Mammary Neoplasms, Experimental
- Longitudinal Studies
- Immunoenzyme Techniques
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Vishwanath, K., Yuan, H., Barry, W. T., Dewhirst, M. W., & Ramanujam, N. (2009). Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors. Neoplasia, 11(9), 889–900. https://doi.org/10.1593/neo.09580
Vishwanath, Karthik, Hong Yuan, William T. Barry, Mark W. Dewhirst, and Nimmi Ramanujam. “Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors.” Neoplasia 11, no. 9 (September 2009): 889–900. https://doi.org/10.1593/neo.09580.
Vishwanath K, Yuan H, Barry WT, Dewhirst MW, Ramanujam N. Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors. Neoplasia. 2009 Sep;11(9):889–900.
Vishwanath, Karthik, et al. “Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors.” Neoplasia, vol. 11, no. 9, Sept. 2009, pp. 889–900. Pubmed, doi:10.1593/neo.09580.
Vishwanath K, Yuan H, Barry WT, Dewhirst MW, Ramanujam N. Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors. Neoplasia. 2009 Sep;11(9):889–900.
Published In
Neoplasia
DOI
EISSN
1476-5586
Publication Date
September 2009
Volume
11
Issue
9
Start / End Page
889 / 900
Location
United States
Related Subject Headings
- Spectrophotometry
- Oxygen
- Oncology & Carcinogenesis
- Monte Carlo Method
- Mice, Nude
- Mice
- Mammary Neoplasms, Experimental
- Longitudinal Studies
- Immunoenzyme Techniques
- Humans