Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting.

Journal Article (Journal Article;Review)

Hypoxia-inducible factor-1 (HIF-1) stabilization is a pivotal event in the response to hypoxic stress. A study in the December 15, 2006 issue of Cancer Research shows that HIF-1 stabilization occurs more robustly as a result of intermittent hypoxia compared with chronic hypoxia. The findings of this study suggest that intermittent hypoxia might influence the efficacy of radiotherapy by more strongly affecting the growth and survival of vascular endothelial cells. This finding offers additional encouragement to efforts to target HIF-1 for cancer therapy.

Full Text

Duke Authors

Cited Authors

  • Dewhirst, MW

Published Date

  • February 1, 2007

Published In

Volume / Issue

  • 67 / 3

Start / End Page

  • 854 - 855

PubMed ID

  • 17283112

International Standard Serial Number (ISSN)

  • 0008-5472

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.CAN-06-4744


  • eng

Conference Location

  • United States