Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting.
Publication
, Journal Article
Dewhirst, MW
Published in: Cancer Res
February 1, 2007
Hypoxia-inducible factor-1 (HIF-1) stabilization is a pivotal event in the response to hypoxic stress. A study in the December 15, 2006 issue of Cancer Research shows that HIF-1 stabilization occurs more robustly as a result of intermittent hypoxia compared with chronic hypoxia. The findings of this study suggest that intermittent hypoxia might influence the efficacy of radiotherapy by more strongly affecting the growth and survival of vascular endothelial cells. This finding offers additional encouragement to efforts to target HIF-1 for cancer therapy.
Duke Scholars
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Published In
Cancer Res
DOI
ISSN
0008-5472
Publication Date
February 1, 2007
Volume
67
Issue
3
Start / End Page
854 / 855
Location
United States
Related Subject Headings
- Partial Pressure
- Oxygen
- Oncology & Carcinogenesis
- Neoplasms
- Hypoxia-Inducible Factor 1
- Humans
- Endothelial Cells
- Cell Hypoxia
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Dewhirst, M. W. (2007). Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. Cancer Res, 67(3), 854–855. https://doi.org/10.1158/0008-5472.CAN-06-4744
Dewhirst, Mark W. “Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting.” Cancer Res 67, no. 3 (February 1, 2007): 854–55. https://doi.org/10.1158/0008-5472.CAN-06-4744.
Dewhirst MW. Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. Cancer Res. 2007 Feb 1;67(3):854–5.
Dewhirst, Mark W. “Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting.” Cancer Res, vol. 67, no. 3, Feb. 2007, pp. 854–55. Pubmed, doi:10.1158/0008-5472.CAN-06-4744.
Dewhirst MW. Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. Cancer Res. 2007 Feb 1;67(3):854–855.
Published In
Cancer Res
DOI
ISSN
0008-5472
Publication Date
February 1, 2007
Volume
67
Issue
3
Start / End Page
854 / 855
Location
United States
Related Subject Headings
- Partial Pressure
- Oxygen
- Oncology & Carcinogenesis
- Neoplasms
- Hypoxia-Inducible Factor 1
- Humans
- Endothelial Cells
- Cell Hypoxia
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology