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Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting.

Publication ,  Journal Article
Dewhirst, MW
Published in: Cancer Res
February 1, 2007

Hypoxia-inducible factor-1 (HIF-1) stabilization is a pivotal event in the response to hypoxic stress. A study in the December 15, 2006 issue of Cancer Research shows that HIF-1 stabilization occurs more robustly as a result of intermittent hypoxia compared with chronic hypoxia. The findings of this study suggest that intermittent hypoxia might influence the efficacy of radiotherapy by more strongly affecting the growth and survival of vascular endothelial cells. This finding offers additional encouragement to efforts to target HIF-1 for cancer therapy.

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Published In

Cancer Res

DOI

ISSN

0008-5472

Publication Date

February 1, 2007

Volume

67

Issue

3

Start / End Page

854 / 855

Location

United States

Related Subject Headings

  • Partial Pressure
  • Oxygen
  • Oncology & Carcinogenesis
  • Neoplasms
  • Hypoxia-Inducible Factor 1
  • Humans
  • Endothelial Cells
  • Cell Hypoxia
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
 

Citation

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Dewhirst, M. W. (2007). Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. Cancer Res, 67(3), 854–855. https://doi.org/10.1158/0008-5472.CAN-06-4744
Dewhirst, Mark W. “Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting.Cancer Res 67, no. 3 (February 1, 2007): 854–55. https://doi.org/10.1158/0008-5472.CAN-06-4744.
Dewhirst, Mark W. “Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting.Cancer Res, vol. 67, no. 3, Feb. 2007, pp. 854–55. Pubmed, doi:10.1158/0008-5472.CAN-06-4744.

Published In

Cancer Res

DOI

ISSN

0008-5472

Publication Date

February 1, 2007

Volume

67

Issue

3

Start / End Page

854 / 855

Location

United States

Related Subject Headings

  • Partial Pressure
  • Oxygen
  • Oncology & Carcinogenesis
  • Neoplasms
  • Hypoxia-Inducible Factor 1
  • Humans
  • Endothelial Cells
  • Cell Hypoxia
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology