Influenza pneumonia in lung transplant recipients: clinical features and association with bronchiolitis obliterans syndrome.

Journal Article (Journal Article)

Influenza infection is increasingly recognized to cause significant morbidity and mortality in the community, especially in pediatric patients and elderly persons. Influenza infection, however, has not been well described among thoracic organ transplant recipients. We provide the first detailed clinical, radiographic, and histologic description of influenza pneumonia among three lung transplant recipients. The presentation varied considerably among the three patients and, in some cases, was atypical for influenza. Despite treatment, a persistent decline in pulmonary function occurred in all three patients after the acute illness. Interestingly, on follow-up biopsy specimens, each patient had histologic evidence of acute rejection and/or obliterative bronchiolitis. Additional research, therefore, is needed to clarify the relationship between influenza infection, acute rejection, and obliterative bronchiolitis.

Full Text

Duke Authors

Cited Authors

  • Garantziotis, S; Howell, DN; McAdams, HP; Davis, RD; Henshaw, NG; Palmer, SM

Published Date

  • April 2001

Published In

Volume / Issue

  • 119 / 4

Start / End Page

  • 1277 - 1280

PubMed ID

  • 11296201

International Standard Serial Number (ISSN)

  • 0012-3692

Digital Object Identifier (DOI)

  • 10.1378/chest.119.4.1277


  • eng

Conference Location

  • United States