Linkage of Charcot-Marie-Tooth neuropathy type 1a to chromosome 17.


Journal Article

Charcot-Marie-Tooth disease Type 1 (CMT) is an inherited neuropathy with known genetic heterogeneity, with at least one autosomal dominant form (CMT Type 1b) linked to the Duffy region of chromosome 1. Autosomal dominant families not demonstrating linkage to the Duffy blood group marker have been designated CMT Type 1a. We report linkage of six CMT Type 1a families to the chromosome 17 markers EW301 (D17S58) and pA10-41 (D17S71) with maximum LOD scores of zeta = 10.49 at theta (maximum recombination fraction) = 0.05 and zeta = 7.36 at theta = 0.06, respectively.

Full Text

Duke Authors

Cited Authors

  • Vance, JM; Nicholson, GA; Yamaoka, LH; Stajich, J; Stewart, CS; Speer, MC; Hung, WY; Roses, AD; Barker, D; Pericak-Vance, MA

Published Date

  • May 1989

Published In

Volume / Issue

  • 104 / 2

Start / End Page

  • 186 - 189

PubMed ID

  • 2707366

Pubmed Central ID

  • 2707366

International Standard Serial Number (ISSN)

  • 0014-4886

Digital Object Identifier (DOI)

  • 10.1016/s0014-4886(89)80013-5


  • eng

Conference Location

  • United States