Linkage of Charcot-Marie-Tooth neuropathy type 1a to chromosome 17.
Publication
, Journal Article
Vance, JM; Nicholson, GA; Yamaoka, LH; Stajich, J; Stewart, CS; Speer, MC; Hung, WY; Roses, AD; Barker, D; Pericak-Vance, MA
Published in: Exp Neurol
May 1989
Charcot-Marie-Tooth disease Type 1 (CMT) is an inherited neuropathy with known genetic heterogeneity, with at least one autosomal dominant form (CMT Type 1b) linked to the Duffy region of chromosome 1. Autosomal dominant families not demonstrating linkage to the Duffy blood group marker have been designated CMT Type 1a. We report linkage of six CMT Type 1a families to the chromosome 17 markers EW301 (D17S58) and pA10-41 (D17S71) with maximum LOD scores of zeta = 10.49 at theta (maximum recombination fraction) = 0.05 and zeta = 7.36 at theta = 0.06, respectively.
Duke Scholars
Published In
Exp Neurol
DOI
ISSN
0014-4886
Publication Date
May 1989
Volume
104
Issue
2
Start / End Page
186 / 189
Location
United States
Related Subject Headings
- Recombination, Genetic
- Neurology & Neurosurgery
- Muscular Atrophy, Spinal
- Male
- Lod Score
- Humans
- Genetic Linkage
- Female
- DNA
- Chromosomes, Human, Pair 17
Citation
APA
Chicago
ICMJE
MLA
NLM
Vance, J. M., Nicholson, G. A., Yamaoka, L. H., Stajich, J., Stewart, C. S., Speer, M. C., … Pericak-Vance, M. A. (1989). Linkage of Charcot-Marie-Tooth neuropathy type 1a to chromosome 17. Exp Neurol, 104(2), 186–189. https://doi.org/10.1016/s0014-4886(89)80013-5
Vance, J. M., G. A. Nicholson, L. H. Yamaoka, J. Stajich, C. S. Stewart, M. C. Speer, W. Y. Hung, A. D. Roses, D. Barker, and M. A. Pericak-Vance. “Linkage of Charcot-Marie-Tooth neuropathy type 1a to chromosome 17.” Exp Neurol 104, no. 2 (May 1989): 186–89. https://doi.org/10.1016/s0014-4886(89)80013-5.
Vance JM, Nicholson GA, Yamaoka LH, Stajich J, Stewart CS, Speer MC, et al. Linkage of Charcot-Marie-Tooth neuropathy type 1a to chromosome 17. Exp Neurol. 1989 May;104(2):186–9.
Vance, J. M., et al. “Linkage of Charcot-Marie-Tooth neuropathy type 1a to chromosome 17.” Exp Neurol, vol. 104, no. 2, May 1989, pp. 186–89. Pubmed, doi:10.1016/s0014-4886(89)80013-5.
Vance JM, Nicholson GA, Yamaoka LH, Stajich J, Stewart CS, Speer MC, Hung WY, Roses AD, Barker D, Pericak-Vance MA. Linkage of Charcot-Marie-Tooth neuropathy type 1a to chromosome 17. Exp Neurol. 1989 May;104(2):186–189.
Published In
Exp Neurol
DOI
ISSN
0014-4886
Publication Date
May 1989
Volume
104
Issue
2
Start / End Page
186 / 189
Location
United States
Related Subject Headings
- Recombination, Genetic
- Neurology & Neurosurgery
- Muscular Atrophy, Spinal
- Male
- Lod Score
- Humans
- Genetic Linkage
- Female
- DNA
- Chromosomes, Human, Pair 17