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Prevalence of clinical isolates of Cryptococcus gattii serotype C among patients with AIDS in Sub-Saharan Africa.

Publication ,  Journal Article
Litvintseva, AP; Thakur, R; Reller, LB; Mitchell, TG
Published in: J Infect Dis
September 1, 2005

Cryptococcus gattii is a group of exogenous, neurotropic yeasts that possess the capsular serotype B or C. Isolates of serotype C are extremely rare and, until recently, were known to infect only immunocompetent individuals. We genotyped 176 isolates of Cryptococcus from patients in sub-Saharan Africa who had AIDS; 22 (13.7%) of 161 isolates from Botswana and 2 (13.3%) of 15 isolates from Malawi were C. gattii serotype C strains. All of these serotype C strains belong to the rare VGIV genotype, possess the MAT alpha mating-type allele, and exhibit little genetic diversity.

Duke Scholars

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

September 1, 2005

Volume

192

Issue

5

Start / End Page

888 / 892

Location

United States

Related Subject Headings

  • Serotyping
  • Random Amplified Polymorphic DNA Technique
  • Polymorphism, Restriction Fragment Length
  • Phylogeny
  • Microbiology
  • Malawi
  • Humans
  • Genetic Variation
  • DNA, Ribosomal Spacer
  • DNA, Fungal
 

Citation

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Litvintseva, A. P., Thakur, R., Reller, L. B., & Mitchell, T. G. (2005). Prevalence of clinical isolates of Cryptococcus gattii serotype C among patients with AIDS in Sub-Saharan Africa. J Infect Dis, 192(5), 888–892. https://doi.org/10.1086/432486
Litvintseva, Anastasia P., Rameshwari Thakur, L Barth Reller, and Thomas G. Mitchell. “Prevalence of clinical isolates of Cryptococcus gattii serotype C among patients with AIDS in Sub-Saharan Africa.J Infect Dis 192, no. 5 (September 1, 2005): 888–92. https://doi.org/10.1086/432486.
Litvintseva AP, Thakur R, Reller LB, Mitchell TG. Prevalence of clinical isolates of Cryptococcus gattii serotype C among patients with AIDS in Sub-Saharan Africa. J Infect Dis. 2005 Sep 1;192(5):888–92.
Litvintseva, Anastasia P., et al. “Prevalence of clinical isolates of Cryptococcus gattii serotype C among patients with AIDS in Sub-Saharan Africa.J Infect Dis, vol. 192, no. 5, Sept. 2005, pp. 888–92. Pubmed, doi:10.1086/432486.
Litvintseva AP, Thakur R, Reller LB, Mitchell TG. Prevalence of clinical isolates of Cryptococcus gattii serotype C among patients with AIDS in Sub-Saharan Africa. J Infect Dis. 2005 Sep 1;192(5):888–892.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

September 1, 2005

Volume

192

Issue

5

Start / End Page

888 / 892

Location

United States

Related Subject Headings

  • Serotyping
  • Random Amplified Polymorphic DNA Technique
  • Polymorphism, Restriction Fragment Length
  • Phylogeny
  • Microbiology
  • Malawi
  • Humans
  • Genetic Variation
  • DNA, Ribosomal Spacer
  • DNA, Fungal