Nodular lymphocyte predominant Hodgkin lymphoma at atypical locations may be associated with increased numbers of large cells and a diffuse histologic component.
Publication
, Journal Article
Yang, DT; Dunphy, CH; Tripp, SR; Lagoo, AS; Perkins, SL
Published in: Am J Hematol
March 2008
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) typically affects predictable lymph node groups with excellent treatment outcomes, but cases with a diffuse histologic pattern are associated with recurrence and rarely, cases will transform to diffuse large B-cell lymphoma. Although increased numbers of large cells has not been associated with poor prognosis, transformation is thought to histologically progress through a stage distinguished by increasing numbers of large atypical B-cells. From 55 cases of NLPHL, we describe a possible subset of NLPHL occurring in older individuals at atypical sites, associated with increased numbers of large cells, a diffuse histologic component, and expression of Bcl-2.
Duke Scholars
Published In
Am J Hematol
DOI
ISSN
0361-8609
Publication Date
March 2008
Volume
83
Issue
3
Start / End Page
218 / 221
Location
United States
Related Subject Headings
- Middle Aged
- Male
- Lymphocytes
- Lymph Nodes
- Immunology
- Immunohistochemistry
- Humans
- Hodgkin Disease
- Female
- Child
Citation
APA
Chicago
ICMJE
MLA
NLM
Yang, D. T., Dunphy, C. H., Tripp, S. R., Lagoo, A. S., & Perkins, S. L. (2008). Nodular lymphocyte predominant Hodgkin lymphoma at atypical locations may be associated with increased numbers of large cells and a diffuse histologic component. Am J Hematol, 83(3), 218–221. https://doi.org/10.1002/ajh.21077
Yang, David T., Cherie H. Dunphy, Sheryl R. Tripp, Anand S. Lagoo, and Sherrie L. Perkins. “Nodular lymphocyte predominant Hodgkin lymphoma at atypical locations may be associated with increased numbers of large cells and a diffuse histologic component.” Am J Hematol 83, no. 3 (March 2008): 218–21. https://doi.org/10.1002/ajh.21077.
Yang DT, Dunphy CH, Tripp SR, Lagoo AS, Perkins SL. Nodular lymphocyte predominant Hodgkin lymphoma at atypical locations may be associated with increased numbers of large cells and a diffuse histologic component. Am J Hematol. 2008 Mar;83(3):218–21.
Yang, David T., et al. “Nodular lymphocyte predominant Hodgkin lymphoma at atypical locations may be associated with increased numbers of large cells and a diffuse histologic component.” Am J Hematol, vol. 83, no. 3, Mar. 2008, pp. 218–21. Pubmed, doi:10.1002/ajh.21077.
Yang DT, Dunphy CH, Tripp SR, Lagoo AS, Perkins SL. Nodular lymphocyte predominant Hodgkin lymphoma at atypical locations may be associated with increased numbers of large cells and a diffuse histologic component. Am J Hematol. 2008 Mar;83(3):218–221.
Published In
Am J Hematol
DOI
ISSN
0361-8609
Publication Date
March 2008
Volume
83
Issue
3
Start / End Page
218 / 221
Location
United States
Related Subject Headings
- Middle Aged
- Male
- Lymphocytes
- Lymph Nodes
- Immunology
- Immunohistochemistry
- Humans
- Hodgkin Disease
- Female
- Child