Nodular lymphocyte predominant Hodgkin lymphoma at atypical locations may be associated with increased numbers of large cells and a diffuse histologic component.

Published

Journal Article

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) typically affects predictable lymph node groups with excellent treatment outcomes, but cases with a diffuse histologic pattern are associated with recurrence and rarely, cases will transform to diffuse large B-cell lymphoma. Although increased numbers of large cells has not been associated with poor prognosis, transformation is thought to histologically progress through a stage distinguished by increasing numbers of large atypical B-cells. From 55 cases of NLPHL, we describe a possible subset of NLPHL occurring in older individuals at atypical sites, associated with increased numbers of large cells, a diffuse histologic component, and expression of Bcl-2.

Full Text

Duke Authors

Cited Authors

  • Yang, DT; Dunphy, CH; Tripp, SR; Lagoo, AS; Perkins, SL

Published Date

  • March 2008

Published In

Volume / Issue

  • 83 / 3

Start / End Page

  • 218 - 221

PubMed ID

  • 17918256

Pubmed Central ID

  • 17918256

International Standard Serial Number (ISSN)

  • 0361-8609

Digital Object Identifier (DOI)

  • 10.1002/ajh.21077

Language

  • eng

Conference Location

  • United States