Overview
My clinical interests are focused on diagnosis of hematological malignancies (leukemia, lymphoma, Hodgkin disease, multiple myeloma, etc). I devote majority of my effort to provide diagnostic interpretation based on morphological examination of blood, bone marrow, lymph node, other lymphoid organs like spleen, as well as any other organ and tissue suspected to harbor lymphoma or leukemia. The morphological findings are integrated with results of ancillary studies including flow cytometry, cytogenetics and molecular diagnostics, as well as key clinical, radiographic, and laboratory findings.
As medical director of the Clinical Flow Cytometry laboratory, I oversee the operations of the lab to ensure accuracy and timely delivery of these high complexity diagnostic tests. Development and validation of flow cytometric tests to provide prognostic information and evaluation of therapeutic targets to guide treatment is also an important aspect of my work.
My translational research interests include-
1. Correlation of flow cytometric, cytogenetic and molecular findings in acute myeloid leukemias with myelodysplasia associated changes and in acute leukemias with monocytic differentiation.
2. Morphological changes following non-conventional treatments for myeloid, lymphoid, and plasma cell neoplasms.
3. The spectrum of lymphoid tissue involvement by plasmacytic / plasmacytoid cells.
As medical director of the Clinical Flow Cytometry laboratory, I oversee the operations of the lab to ensure accuracy and timely delivery of these high complexity diagnostic tests. Development and validation of flow cytometric tests to provide prognostic information and evaluation of therapeutic targets to guide treatment is also an important aspect of my work.
My translational research interests include-
1. Correlation of flow cytometric, cytogenetic and molecular findings in acute myeloid leukemias with myelodysplasia associated changes and in acute leukemias with monocytic differentiation.
2. Morphological changes following non-conventional treatments for myeloid, lymphoid, and plasma cell neoplasms.
3. The spectrum of lymphoid tissue involvement by plasmacytic / plasmacytoid cells.
Office Hours
Monday through Friday, 8 am to 5 pm.
For appointments call divisional secretary at 919-684-2486.
For appointments call divisional secretary at 919-684-2486.
Current Appointments & Affiliations
Professor of Pathology
·
2012 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
2018 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Flow cytometry quantification of tumor-infiltrating lymphocytes to predict the survival of patients with diffuse large B-cell lymphoma.
Journal Article Front Immunol · 2024 INTRODUCTION: Our previous studies have demonstrated that tumor-infiltrating lymphocytes (TILs), including normal B cells, T cells, and natural killer (NK) cells, in diffuse large B-cell lymphoma (DLBCL) have a significantly favorable impact on the clinica ... Full text Open Access Link to item CiteHow to Design and Validate a Clinical Flow Cytometry Assay.
Journal Article Clin Lab Med · September 2023 Multiparametric flow cytometry assays are long recognized as an essential diagnostic test for leukemias and lymphomas. Lacking Food and Drug Administration-approved standardized tests, these assays remain laboratory developed tests. The recently published ... Full text Link to item CiteA 79-Year-Old Female Patient With Altered Mental Status and Anemia.
Journal Article Arthritis Care Res (Hoboken) · April 2022 Full text Link to item CiteRecent Grants
Aging and Immune Response in Sepsis
ResearchConsultant · Awarded by National Institutes of Health · 2007 - 2010View All Grants
Education, Training & Certifications
University of Texas Medical School, Houston ·
1989
Ph.D.
Gujarat University, B.J. Medical College (India) ·
1980
M.D.
Gujarat University, B.J. Medical College (India) ·
1977
M.B.B.S.