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The significance of elevated troponin T in patients with nondialysis-dependent renal insufficiency: a validation with coronary angiography.

Publication ,  Journal Article
Heitner, JF; Curtis, JP; Haq, SA; Corey, GR; Newby, LK; Jollis, JG
Published in: Clin Cardiol
July 2005

BACKGROUND: Patients with elevated troponin are at high risk of adverse outcomes, future cardiac events, and are more likely to have hemodynamically significant coronary artery stenoses. Elevated troponin T (cTnT) in patients with poor renal function portends a poor prognosis; however, findings of significant coronary artery disease (CAD) by coronary angiography have not been demonstrated in patients with poor renal function and elevated cTnT. HYPOTHESIS: The purpose of this study was to correlate the angiographic findings of patients with elevated cTnT with respect to renal function in patients with nondialysis-dependent renal insufficiency. METHODS: We retrospectively identified 342 patients with elevated cTnT who underwent coronary angiography in the setting of acute coronary syndrome. Patients were divided into poor (< 40 ml/min) and normal (> 40 ml/min) renal function by measuring their glomerular filtration rate. Our primary outcome was CAD stenosis, defined as epicardial stenosis > or = 70%. Secondary outcomes were rates of contrast nephropathy, initiation of hemodialysis, revascularization, length of stay (LOS), and in-hospital mortality. RESULTS: There was no significant difference in the prevalence of CAD between patients who had positive cTnT with poor renal function versus patients with positive cTnT and normal renal function (87.1 vs. 89.7%, p = 0.54). This finding persisted after stratifying by age. Patients with impaired renal function had a higher mortality, longer LOS, and a higher rate contrast nephropathy requiring hemodialysis. CONCLUSION: The association between elevated cTnT and significant CAD stenosis does not vary with renal function.

Duke Scholars

Published In

Clin Cardiol

DOI

ISSN

0160-9289

Publication Date

July 2005

Volume

28

Issue

7

Start / End Page

333 / 336

Location

United States

Related Subject Headings

  • Troponin T
  • Risk Factors
  • Retrospective Studies
  • Renal Insufficiency
  • Prognosis
  • Prevalence
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Humans
 

Citation

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ICMJE
MLA
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Heitner, J. F., Curtis, J. P., Haq, S. A., Corey, G. R., Newby, L. K., & Jollis, J. G. (2005). The significance of elevated troponin T in patients with nondialysis-dependent renal insufficiency: a validation with coronary angiography. Clin Cardiol, 28(7), 333–336. https://doi.org/10.1002/clc.4960280706
Heitner, John F., Jeptha P. Curtis, Salman A. Haq, G Ralph Corey, L Kristin Newby, and James G. Jollis. “The significance of elevated troponin T in patients with nondialysis-dependent renal insufficiency: a validation with coronary angiography.Clin Cardiol 28, no. 7 (July 2005): 333–36. https://doi.org/10.1002/clc.4960280706.
Heitner JF, Curtis JP, Haq SA, Corey GR, Newby LK, Jollis JG. The significance of elevated troponin T in patients with nondialysis-dependent renal insufficiency: a validation with coronary angiography. Clin Cardiol. 2005 Jul;28(7):333–6.
Heitner, John F., et al. “The significance of elevated troponin T in patients with nondialysis-dependent renal insufficiency: a validation with coronary angiography.Clin Cardiol, vol. 28, no. 7, July 2005, pp. 333–36. Pubmed, doi:10.1002/clc.4960280706.
Heitner JF, Curtis JP, Haq SA, Corey GR, Newby LK, Jollis JG. The significance of elevated troponin T in patients with nondialysis-dependent renal insufficiency: a validation with coronary angiography. Clin Cardiol. 2005 Jul;28(7):333–336.

Published In

Clin Cardiol

DOI

ISSN

0160-9289

Publication Date

July 2005

Volume

28

Issue

7

Start / End Page

333 / 336

Location

United States

Related Subject Headings

  • Troponin T
  • Risk Factors
  • Retrospective Studies
  • Renal Insufficiency
  • Prognosis
  • Prevalence
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Humans