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In vitro resistance to thrombin-induced platelet microbicidal protein in isolates of Staphylococcus aureus from endocarditis patients correlates with an intravascular device source.

Publication ,  Journal Article
Fowler, VG; McIntyre, LM; Yeaman, MR; Peterson, GE; Barth Reller, L; Corey, GR; Wray, D; Bayer, AS
Published in: J Infect Dis
October 2000

Platelet microbicidal proteins (PMPs) are small antimicrobial peptides secreted by mammalian platelets. In vitro resistance of Staphylococcus aureus strains to PMPs correlates with more extensive disease in experimental infective endocarditis (IE). To determine whether this same relationship exists in human S. aureus IE, we evaluated the in vitro PMP susceptibility phenotype of isolates from 58 prospectively-identified patients with definite S. aureus IE. On multivariate analyses, patients with S. aureus IE complicating an infected intravascular device were significantly more likely to have IE caused by a PMP-resistant strain (P=.0193). No correlations were detected between in vitro PMP resistance among S. aureus strains and the severity of human IE. This work supports the concept that in vitro PMP resistance in clinical S. aureus strains is associated with important clinical characteristics of S. aureus endovascular infections in vivo.

Duke Scholars

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

October 2000

Volume

182

Issue

4

Start / End Page

1251 / 1254

Location

United States

Related Subject Headings

  • beta-Thromboglobulin
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Renal Dialysis
  • Multivariate Analysis
  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Heart Valve Prosthesis
  • Endocarditis, Bacterial
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fowler, V. G., McIntyre, L. M., Yeaman, M. R., Peterson, G. E., Barth Reller, L., Corey, G. R., … Bayer, A. S. (2000). In vitro resistance to thrombin-induced platelet microbicidal protein in isolates of Staphylococcus aureus from endocarditis patients correlates with an intravascular device source. J Infect Dis, 182(4), 1251–1254. https://doi.org/10.1086/315812
Fowler, V. G., L. M. McIntyre, M. R. Yeaman, G. E. Peterson, L. Barth Reller, G. R. Corey, D. Wray, and A. S. Bayer. “In vitro resistance to thrombin-induced platelet microbicidal protein in isolates of Staphylococcus aureus from endocarditis patients correlates with an intravascular device source.J Infect Dis 182, no. 4 (October 2000): 1251–54. https://doi.org/10.1086/315812.
Fowler VG, McIntyre LM, Yeaman MR, Peterson GE, Barth Reller L, Corey GR, et al. In vitro resistance to thrombin-induced platelet microbicidal protein in isolates of Staphylococcus aureus from endocarditis patients correlates with an intravascular device source. J Infect Dis. 2000 Oct;182(4):1251–4.
Fowler VG, McIntyre LM, Yeaman MR, Peterson GE, Barth Reller L, Corey GR, Wray D, Bayer AS. In vitro resistance to thrombin-induced platelet microbicidal protein in isolates of Staphylococcus aureus from endocarditis patients correlates with an intravascular device source. J Infect Dis. 2000 Oct;182(4):1251–1254.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

October 2000

Volume

182

Issue

4

Start / End Page

1251 / 1254

Location

United States

Related Subject Headings

  • beta-Thromboglobulin
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Renal Dialysis
  • Multivariate Analysis
  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Heart Valve Prosthesis
  • Endocarditis, Bacterial