Overview
Determinants of Outcome in Patients with Staphylococcus aureus Bacteremia
Antibacterial Resistance
Pathogenesis of Bacterial Infections
Tropical medicine/International Health
Antibacterial Resistance
Pathogenesis of Bacterial Infections
Tropical medicine/International Health
Current Appointments & Affiliations
Florence McAlister Distinguished Professor of Medicine
·
2019 - Present
Medicine, Infectious Diseases,
Medicine
Professor of Medicine
·
2012 - Present
Medicine, Infectious Diseases,
Medicine
Professor in Molecular Genetics and Microbiology
·
2012 - Present
Molecular Genetics and Microbiology,
Basic Science Departments
Member in the Duke Clinical Research Institute
·
2001 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
Methicillin-resistant and susceptible Staphylococcus aureus: tolerance, immune evasion and treatment.
Journal Article Nat Rev Microbiol · February 2026 Staphylococcus aureus is capable of infecting every organ system in the body and developing resistance to every available antibiotic used to treat it, such as methicillin-resistant S. aureus (commonly referred to as MRSA). This pathogen is characterized by ... Full text Link to item CiteGenetics and environment distinctively shape the human immune cell epigenome.
Journal Article Nat Genet · January 27, 2026 The epigenome of human immune cells is shaped by both genetics and environmental factors, yet the relative contributions of these influences remain incompletely characterized. Here we use single-nucleus methylation sequencing and assay for transposase-acce ... Full text Link to item CiteThe innate immune protein calprotectin ablates the bactericidal activity of β-lactam antibiotics.
Journal Article Proc Natl Acad Sci U S A · January 20, 2026 β-lactam antibiotics are among the most widely used treatments for bacterial infections, yet therapeutic failure is common even when no genetic resistance is detected. Understanding how host factors influence antibiotic efficacy is critical for improving o ... Full text Link to item CiteRecent Grants
2/3 CTSA K12 Program at Duke University
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030Genomic determinants of antibiotic treatment failure in S. aureus bacteremia
ResearchMentor · Awarded by National Institutes of Health · 2024 - 2029Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2022 - 2027View All Grants
Education, Training & Certifications
Duke University ·
1999
M.H.S.
University of North Carolina, Chapel Hill ·
1993
M.D.