Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus.

Journal Article (Journal Article)

Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime. Ceftobiprole showed the lowest MICs at a high inoculum but with a slight increase for Bla-positive versus Bla-negative strains. Since a potential therapeutic effect associated with a cephalosporin inoculum effect has been described, further studies are warranted.

Full Text

Duke Authors

Cited Authors

  • Nannini, EC; Stryjewski, ME; Singh, KV; Rude, TH; Corey, GR; Fowler, VG; Murray, BE

Published Date

  • May 2010

Published In

Volume / Issue

  • 54 / 5

Start / End Page

  • 2206 - 2208

PubMed ID

  • 20211890

Pubmed Central ID

  • PMC2863656

Electronic International Standard Serial Number (EISSN)

  • 1098-6596

Digital Object Identifier (DOI)

  • 10.1128/AAC.01325-09


  • eng

Conference Location

  • United States