Oncolytic viruses for cancer therapy II. Cell-internal factors for conditional growth in neoplastic cells.

Journal Article (Journal Article;Review)

Recent advances in our understanding of virus-host interactions have fueled new studies in the field of oncolytic viruses. The first part of this review explained how cell-external factors, such as cellular receptors, influence tumor tropism and specificity of oncolytic virus candidates. In the second part of this review, we focus on cellinternal factors that mediate tumor-specific virus growth. An oncolytic virus must be able to replicate within cancerous cells and kill them without collateral damage to healthy surrounding cells. This desirable property is inherent to some proposed oncolytic viral agents or has been achieved by genetic manipulation in others.

Full Text

Duke Authors

Cited Authors

  • Campbell, SA; Gromeier, M

Published Date

  • April 2005

Published In

Volume / Issue

  • 28 / 4

Start / End Page

  • 209 - 215

PubMed ID

  • 15840970

International Standard Serial Number (ISSN)

  • 0378-584X

Digital Object Identifier (DOI)

  • 10.1159/000084010


  • eng

Conference Location

  • Switzerland