Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism.
Published
Journal Article
Autistic children show elevated serum levels of autoantibodies to several proteins essential for the function of normal brains. The voltage-dependent anion channel (VDAC) and hexokinase-I, a VDAC protective ligand, were identified as targets of this autoimmunity in autistic children. These autoantibodies were purified using immunoaffinity chromatographic techniques. Both antibodies induce apoptosis of cultured human neuroblastoma cells. Because VDAC and hexokinase-I are essential for brain protection from ischemic damage, the presence of these autoantibodies suggests a possible causal role in the neurologic pathogenesis of autism.
Full Text
Duke Authors
Cited Authors
- Gonzalez-Gronow, M; Cuchacovich, M; Francos, R; Cuchacovich, S; Fernandez, MDP; Blanco, A; Bowers, EV; Kaczowka, S; Pizzo, SV
Published Date
- October 8, 2010
Published In
Volume / Issue
- 227 / 1-2
Start / End Page
- 153 - 161
PubMed ID
- 20576296
Pubmed Central ID
- 20576296
Electronic International Standard Serial Number (EISSN)
- 1872-8421
Digital Object Identifier (DOI)
- 10.1016/j.jneuroim.2010.06.001
Language
- eng
Conference Location
- Netherlands