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Prevalence of pulmonary atypical alveolar cell hyperplasia in an autopsy population: a study of 100 cases.

Publication ,  Journal Article
Sterner, DJ; Mori, M; Roggli, VL; Fraire, AE
Published in: Mod Pathol
May 1997

A precursor lesion of pulmonary adenocarcinoma has not been clearly defined. Previous studies suggested that atypical alveolar cell hyperplasia (AACH) might represent such a precursor lesion. Most previous studies showed an association between AACH and adenocarcinoma in surgical resection specimens. In this study, we searched for the prevalence of AACH and nonatypical alveolar cell hyperplasia (ACH) in a general autopsy population. Cases in which there was clinical or anatomic evidence of pulmonary neoplasia were excluded from the study. In the 100 consecutive autopsies examined, we found four cases of ACH and two cases of AACH. The two AACH lesions showed cytologic atypia and stained positively for p53 and c-erb-2. These findings suggest a possible role for AACH as a precursor lesion of adenocarcinoma of the lung.

Duke Scholars

Published In

Mod Pathol

ISSN

0893-3952

Publication Date

May 1997

Volume

10

Issue

5

Start / End Page

469 / 473

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Smoking
  • Retrospective Studies
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Pulmonary Alveoli
  • Precancerous Conditions
  • Pathology
  • Middle Aged
  • Male
 

Citation

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MLA
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Sterner, D. J., Mori, M., Roggli, V. L., & Fraire, A. E. (1997). Prevalence of pulmonary atypical alveolar cell hyperplasia in an autopsy population: a study of 100 cases. Mod Pathol, 10(5), 469–473.
Sterner, D. J., M. Mori, V. L. Roggli, and A. E. Fraire. “Prevalence of pulmonary atypical alveolar cell hyperplasia in an autopsy population: a study of 100 cases.Mod Pathol 10, no. 5 (May 1997): 469–73.
Sterner DJ, Mori M, Roggli VL, Fraire AE. Prevalence of pulmonary atypical alveolar cell hyperplasia in an autopsy population: a study of 100 cases. Mod Pathol. 1997 May;10(5):469–73.
Sterner, D. J., et al. “Prevalence of pulmonary atypical alveolar cell hyperplasia in an autopsy population: a study of 100 cases.Mod Pathol, vol. 10, no. 5, May 1997, pp. 469–73.
Sterner DJ, Mori M, Roggli VL, Fraire AE. Prevalence of pulmonary atypical alveolar cell hyperplasia in an autopsy population: a study of 100 cases. Mod Pathol. 1997 May;10(5):469–473.

Published In

Mod Pathol

ISSN

0893-3952

Publication Date

May 1997

Volume

10

Issue

5

Start / End Page

469 / 473

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Smoking
  • Retrospective Studies
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Pulmonary Alveoli
  • Precancerous Conditions
  • Pathology
  • Middle Aged
  • Male