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Lung cancer heterogeneity: a blinded and randomized study of 100 consecutive cases.

Publication ,  Journal Article
Roggli, VL; Vollmer, RT; Greenberg, SD; McGavran, MH; Spjut, HJ; Yesner, R
Published in: Hum Pathol
June 1985

The heterogeneity of lung carcinomas was recognized in the past, but few previous studies attempted to quantitate this heterogeneity. In the present study 100 consecutive cases of lung carcinoma (65 surgical resections and 35 autopsies) were collected, and either the entire tumor or ten blocks were examined in a blinded and randomized fashion using the revised (1981) WHO classification. At least three of five panelists agreed on the major histologic type present for 94 per cent of the slides. Agreement for the diagnosis of small cell carcinomas (at least four of five observers) was 98 per cent, but only 72 per cent agreement was attained for the subtyping of small cell carcinomas (e.g., oat cell versus intermediate). Only 34 per cent of the cases were homogeneous according to the majority of the panelists. An additional 21 per cent of the cases showed minor (subtype) heterogeneity (e.g., mixtures of acinar and papillary patterns in adenocarcinoma). Forty-five per cent of the cases showed major heterogeneity, i.e., at least one slide from the case showed a major histologic type different from that of the remainder. Seven small cell carcinomas were homogeneous, whereas in eight cases mixtures of small cell and other cell types were seen. In all but one of the cases involving bronchioloalveolar cell patterns, other patterns of adenocarcinoma were present elsewhere in the tumor. In all six cases involving giant cell carcinoma patterns, adenocarcinoma patterns were also present in some sections. Heterogeneity was identified by extensive sampling of the entire tumor and was seldom recognized in biopsy specimens.

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Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

June 1985

Volume

16

Issue

6

Start / End Page

569 / 579

Location

United States

Related Subject Headings

  • Pneumonectomy
  • Pathology
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Female
  • Carcinoma, Squamous Cell
  • Carcinoma, Small Cell
  • Biopsy
 

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Roggli, V. L., Vollmer, R. T., Greenberg, S. D., McGavran, M. H., Spjut, H. J., & Yesner, R. (1985). Lung cancer heterogeneity: a blinded and randomized study of 100 consecutive cases. Hum Pathol, 16(6), 569–579. https://doi.org/10.1016/s0046-8177(85)80106-4
Roggli, V. L., R. T. Vollmer, S. D. Greenberg, M. H. McGavran, H. J. Spjut, and R. Yesner. “Lung cancer heterogeneity: a blinded and randomized study of 100 consecutive cases.Hum Pathol 16, no. 6 (June 1985): 569–79. https://doi.org/10.1016/s0046-8177(85)80106-4.
Roggli VL, Vollmer RT, Greenberg SD, McGavran MH, Spjut HJ, Yesner R. Lung cancer heterogeneity: a blinded and randomized study of 100 consecutive cases. Hum Pathol. 1985 Jun;16(6):569–79.
Roggli, V. L., et al. “Lung cancer heterogeneity: a blinded and randomized study of 100 consecutive cases.Hum Pathol, vol. 16, no. 6, June 1985, pp. 569–79. Pubmed, doi:10.1016/s0046-8177(85)80106-4.
Roggli VL, Vollmer RT, Greenberg SD, McGavran MH, Spjut HJ, Yesner R. Lung cancer heterogeneity: a blinded and randomized study of 100 consecutive cases. Hum Pathol. 1985 Jun;16(6):569–579.
Journal cover image

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

June 1985

Volume

16

Issue

6

Start / End Page

569 / 579

Location

United States

Related Subject Headings

  • Pneumonectomy
  • Pathology
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Female
  • Carcinoma, Squamous Cell
  • Carcinoma, Small Cell
  • Biopsy