Skip to main content
Journal cover image

N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain.

Publication ,  Journal Article
Minard, FN; Cain, JC; Grant, DS; Dren, AT
Published in: The Journal of pharmacy and pharmacology
February 1979

N-o-Methoxyphenylpiperazine (MPP) is a moderately effective in vivo blocker of dopaminergic receptors. Its ability to increase the concentration of rat brain homovanillic acid (HVA) and the resulting time course for HVA were similar to the actions of clozapine. The increased concentration of HVA did not result from decreased outflow from brain because HVA also rapidly decreased after a subsequent injection of pargyline. MPP blocked the circling behaviour caused by apomorphine in mice with a unilateral striatal lesion, and MPP and apomorphine reciprocally blocked the occurrence of stereotypy and increased HVA in rats. Diazepam partially prevented the MPP-induced elevation of HVA. Thus, both biochemical and pharmacological evidence indicate the dopaminergic blocking action of MPP.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

The Journal of pharmacy and pharmacology

DOI

EISSN

2042-7158

ISSN

0022-3573

Publication Date

February 1979

Volume

31

Issue

2

Start / End Page

91 / 93

Related Subject Headings

  • Time Factors
  • Receptors, Dopamine
  • Rats
  • Piperazines
  • Pharmacology & Pharmacy
  • Pargyline
  • Male
  • In Vitro Techniques
  • Hydroxydopamines
  • Homovanillic Acid
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Minard, F. N., Cain, J. C., Grant, D. S., & Dren, A. T. (1979). N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain. The Journal of Pharmacy and Pharmacology, 31(2), 91–93. https://doi.org/10.1111/j.2042-7158.1979.tb13439.x
Minard, F. N., J. C. Cain, D. S. Grant, and A. T. Dren. “N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain.The Journal of Pharmacy and Pharmacology 31, no. 2 (February 1979): 91–93. https://doi.org/10.1111/j.2042-7158.1979.tb13439.x.
Minard FN, Cain JC, Grant DS, Dren AT. N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain. The Journal of pharmacy and pharmacology. 1979 Feb;31(2):91–3.
Minard, F. N., et al. “N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain.The Journal of Pharmacy and Pharmacology, vol. 31, no. 2, Feb. 1979, pp. 91–93. Epmc, doi:10.1111/j.2042-7158.1979.tb13439.x.
Minard FN, Cain JC, Grant DS, Dren AT. N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain. The Journal of pharmacy and pharmacology. 1979 Feb;31(2):91–93.
Journal cover image

Published In

The Journal of pharmacy and pharmacology

DOI

EISSN

2042-7158

ISSN

0022-3573

Publication Date

February 1979

Volume

31

Issue

2

Start / End Page

91 / 93

Related Subject Headings

  • Time Factors
  • Receptors, Dopamine
  • Rats
  • Piperazines
  • Pharmacology & Pharmacy
  • Pargyline
  • Male
  • In Vitro Techniques
  • Hydroxydopamines
  • Homovanillic Acid