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Premier: a clinical trial of comprehensive lifestyle modification for blood pressure control: rationale, design and baseline characteristics.

Publication ,  Journal Article
Svetkey, LP; Harsha, DW; Vollmer, WM; Stevens, VJ; Obarzanek, E; Elmer, PJ; Lin, PH; Champagne, C; Simons-Morton, DG; Aickin, M; Proschan, MA ...
Published in: Ann Epidemiol
July 2003

PURPOSE: To describe PREMIER, a randomized trial to determine the effects of multi-component lifestyle interventions on blood pressure (BP). METHODS: Participants with above optimal BP through stage 1 hypertension were randomized to: 1) a behavioral lifestyle (BLS) intervention that implements established recommendations, 2) a BLS intervention that implements established recommendations plus the DASH diet, or 3) an advice only standard of care group. The two BLS interventions consist of group and individual counseling sessions for 18 months. The primary outcome is systolic BP at 6 months. Additional outcomes include diastolic BP and homocysteine at 6 months; systolic and diastolic BP at 18 months; fasting lipids, glucose and insulin at 6 and 18 months; and effects in subgroup. CONCLUSION: Results from the PREMIER trial will provide scientific rationale for implementing multi-component behavioral lifestyle intervention programs to control BP and prevent CVD.

Duke Scholars

Published In

Ann Epidemiol

DOI

ISSN

1047-2797

Publication Date

July 2003

Volume

13

Issue

6

Start / End Page

462 / 471

Location

United States

Related Subject Headings

  • United States
  • Risk Reduction Behavior
  • Patient Compliance
  • National Institutes of Health (U.S.)
  • Middle Aged
  • Male
  • Linear Models
  • Life Style
  • Hypertension
  • Humans
 

Citation

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ICMJE
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Svetkey, L. P., Harsha, D. W., Vollmer, W. M., Stevens, V. J., Obarzanek, E., Elmer, P. J., … Appel, L. J. (2003). Premier: a clinical trial of comprehensive lifestyle modification for blood pressure control: rationale, design and baseline characteristics. Ann Epidemiol, 13(6), 462–471. https://doi.org/10.1016/s1047-2797(03)00006-1
Svetkey, Laura P., David W. Harsha, William M. Vollmer, Victor J. Stevens, Eva Obarzanek, Patricia J. Elmer, Pao Hwa Lin, et al. “Premier: a clinical trial of comprehensive lifestyle modification for blood pressure control: rationale, design and baseline characteristics.Ann Epidemiol 13, no. 6 (July 2003): 462–71. https://doi.org/10.1016/s1047-2797(03)00006-1.
Svetkey LP, Harsha DW, Vollmer WM, Stevens VJ, Obarzanek E, Elmer PJ, et al. Premier: a clinical trial of comprehensive lifestyle modification for blood pressure control: rationale, design and baseline characteristics. Ann Epidemiol. 2003 Jul;13(6):462–71.
Svetkey, Laura P., et al. “Premier: a clinical trial of comprehensive lifestyle modification for blood pressure control: rationale, design and baseline characteristics.Ann Epidemiol, vol. 13, no. 6, July 2003, pp. 462–71. Pubmed, doi:10.1016/s1047-2797(03)00006-1.
Svetkey LP, Harsha DW, Vollmer WM, Stevens VJ, Obarzanek E, Elmer PJ, Lin PH, Champagne C, Simons-Morton DG, Aickin M, Proschan MA, Appel LJ. Premier: a clinical trial of comprehensive lifestyle modification for blood pressure control: rationale, design and baseline characteristics. Ann Epidemiol. 2003 Jul;13(6):462–471.
Journal cover image

Published In

Ann Epidemiol

DOI

ISSN

1047-2797

Publication Date

July 2003

Volume

13

Issue

6

Start / End Page

462 / 471

Location

United States

Related Subject Headings

  • United States
  • Risk Reduction Behavior
  • Patient Compliance
  • National Institutes of Health (U.S.)
  • Middle Aged
  • Male
  • Linear Models
  • Life Style
  • Hypertension
  • Humans