PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration.

Journal Article (Journal Article)

The pathophysiology of 'early' dry age-related macular degeneration (ARMD), characterized by the accumulation of lipid and protein-rich sub-retinal deposits remains largely unknown. Accumulation and dysregulated turnover of lipids as well as extracellular matrix (ECM) molecules in sub-retinal pigment epithelial (RPE) deposits and Bruch's membrane, itself an ECM, play a role in ARMD. Epidemiological studies have shown an increased risk for the disease associated with higher dietary intake of long chain poly-unsaturated fatty acids (LCPUFA) and specifically more so for n-6 versus n-3 fatty acids. PUFAs are membrane targets of lipid peroxidation and natural ligands for the nuclear receptors, peroxisome proliferator activated receptors (PPAR). Here we investigated the expression of genes involved in lipid metabolism and expression of the three isoforms of PPARs in an immortalized cell line of human RPE cells (ARPE19) in the presence or absence of fatty acids.

Full Text

Duke Authors

Cited Authors

  • Malek, G; Hu, P; Wielgus, A; Dwyer, M; Cousins, S

Published Date

  • 2010

Published In

Volume / Issue

  • 664 /

Start / End Page

  • 429 - 436

PubMed ID

  • 20238044

International Standard Serial Number (ISSN)

  • 0065-2598

Digital Object Identifier (DOI)

  • 10.1007/978-1-4419-1399-9_49


  • eng

Conference Location

  • United States