Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Trainee, Research, University of Alabama Birmingham 2002
  • Ph.D., University of Alabama Birmingham 2002
• 

  Previous Appointments & Affiliations

  • Vice-Chair of Diversity, Equity and Inclusion, Ophthalmology, Clinical Science Departments 2021
  • Associate Professor of Ophthalmology, Ophthalmology, Clinical Science Departments 2014 - 2018
  • Assistant Professor in Pathology, Pathology, Clinical Science Departments 2008 - 2014
  • Assistant Professor of Ophthalmology, Ophthalmology, Clinical Science Departments 2011 - 2014
  • Assistant Professor in Ophthalmology, Ophthalmology, Clinical Science Departments 2007 - 2011
  • Assistant Professor in Ophthalmology, Ophthalmology, Clinical Science Departments 2006 - 2007
• Research
• 

  Selected Grants

  • Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
  • Nuclear receptor driven mechanisms in aging and AMD awarded by National Institutes of Health 2021 - 2025
  • Duke University Program in Environmental Health awarded by National Institutes of Health 2019 - 2024
  • Regulation of inflammation and lipid homeostasis by the aryl hydrocarbon receptor in age-related macular degeneration awarded by National Institutes of Health 2018 - 2023
  • Novel signaling pathways regulated by the liver x receptor in age-related macular degeneration awarded by National Institutes of Health 2018 - 2022
  • Exploring the role of ERR Alpha (Estrogen Related Receptor Alpha) in the eye as a function of age and AMD (Age related Macular Degeneration) awarded by Fight For Sight, Inc. 2022
  • Testing Gene Therapy in Models of Geographic Atrophy awarded by University of Florida 2016 - 2022
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • LXR as a novel therapeutic target in diabetic retinopathy awarded by University of Alabama at Birmingham 2017 - 2019
  • Investigating the role of a novel nuclear receptor in aging and AMD. awarded by Carl Marshall Reeves & Mildred Almen Reeves Foundation, Inc. 2017 - 2018
  • The role of a macrophage chemotactic factor in AMD awarded by BrightFocus Foundation 2015 - 2017
  • Targeting the signaling pathway of a lipid activated nuclear receptor for the treatment of dry age-related macular degeneration. awarded by Edward N. & Della L. Thome Memorial Foundation 2014 - 2017
  • LXR as a novel therapeutic target in diabetic retinopathy awarded by The Trustees of Indiana University 2015 - 2017
  • Lipid Activated Nuclear Receptors in Age-Related Macular Degeneration awarded by National Institutes of Health 2011 - 2017
  • Immune Responses in Macular Degeneration awarded by National Institutes of Health 2005 - 2011
• 

  External Relationships

  • Allianthera Biopharma (ATB)
  • Current Eye Research Journal / Taylor and Francis
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Malek, Goldis. “Location of Retinal Pigment Epithelial Cells in the Eye Is Critical to Their Function.” Am J Pathol, May 7, 2023. https://doi.org/10.1016/j.ajpath.2023.04.005.
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    • Ahmad, Sarfaraz, Kendra N. Wright, Jessica L. VonCannon, Carlos M. Ferrario, Mohammad S. Ola, Mayur Choudhary, Goldis Malek, Jenna R. Gustafson, and Rebecca M. Sappington. “Internalization of Angiotensin-(1-12) in Adult Retinal Pigment Epithelial-19 Cells.” J Ocul Pharmacol Ther 39, no. 4 (May 2023): 290–99. https://doi.org/10.1089/jop.2022.0139.
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    • Choudhary, Mayur, and Goldis Malek. “Potential therapeutic targets for age-related macular degeneration: The nuclear option.” Prog Retin Eye Res 94 (May 2023): 101130. https://doi.org/10.1016/j.preteyeres.2022.101130.
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    • Peavey, Jeremy, Vipul M. Parmar, and Goldis Malek. “Correction: Peavey et al. Nuclear Receptor Atlases of Choroidal Tissues Reveal Candidate Receptors Associated with Age-Related Macular Degeneration. Cells 2022, 11, 2386.” Cells 11, no. 24 (December 7, 2022). https://doi.org/10.3390/cells11243948.
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    • Malek, Goldis, Judith Campisi, Koji Kitazawa, Corey Webster, Aparna Lakkaraju, and Dorota Skowronska-Krawczyk. “Does senescence play a role in age-related macular degeneration?” Exp Eye Res 225 (December 2022): 109254. https://doi.org/10.1016/j.exer.2022.109254.
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    • Choudhary, Mayur, Faryan Tayyari, James T. Handa, and Goldis Malek. “Characterization and identification of measurable endpoints in a mouse model featuring age-related retinal pathologies: a platform to test therapies.” Lab Invest 102, no. 10 (October 2022): 1132–42. https://doi.org/10.1038/s41374-022-00795-7.
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    • Choudhary, Mayur, Faryan Tayyari, James T. Handa, and Goldis Malek. “Characterization and identification of measurable endpoints in a mouse model featuring age-related retinal pathologies: a platform to test therapies.” Lab Invest 102, no. 10 (October 2022): 1132–42. https://doi.org/10.1038/s41374-022-00795-7.
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    • Bharti, Kapil, Anneke I. den Hollander, Aparna Lakkaraju, Debasish Sinha, David S. Williams, Silvia C. Finnemann, Catherine Bowes-Rickman, Goldis Malek, and Patricia A. D’Amore. “Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration.” Exp Eye Res 222 (September 2022): 109170. https://doi.org/10.1016/j.exer.2022.109170.
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    • Peavey, Jeremy, Vipul M. Parmar, and Goldis Malek. “Nuclear Receptor Atlases of Choroidal Tissues Reveal Candidate Receptors Associated with Age-Related Macular Degeneration.” Cells 11, no. 15 (August 2, 2022). https://doi.org/10.3390/cells11152386.
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    • Csaky, Karl, Christine A. Curcio, Robert F. Mullins, Philip J. Rosenfeld, James Fujimoto, Bärbel Rohrer, Ramiro Ribero, et al. “New approaches to the treatment of Age-Related Macular Degeneration (AMD).” Exp Eye Res 221 (August 2022): 109134. https://doi.org/10.1016/j.exer.2022.109134.
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    • Yao, Pei-Li, Vipul M. Parmar, Mayur Choudhary, and Goldis Malek. “NURR1 expression regulates retinal pigment epithelial-mesenchymal transition and age-related macular degeneration phenotypes.” Proc Natl Acad Sci U S A 119, no. 28 (July 12, 2022): e2202256119. https://doi.org/10.1073/pnas.2202256119.
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    • Choudhary, Mayur, Cristhian J. Ildefonso, Alfred S. Lewin, and Goldis Malek. “Gene Delivery of a Caspase Activation and Recruitment Domain Improves Retinal Pigment Epithelial Function and Modulates Inflammation in a Mouse Model with Features of Dry Age-Related Macular Degeneration.” J Ocul Pharmacol Ther 38, no. 5 (June 2022): 359–71. https://doi.org/10.1089/jop.2022.0002.
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    • Ahmad, Sarfaraz, Kendra N. Wright, Carlos M. Ferrario, Heng-Jie Cheng, Mayur Choudhary, Goldis Malek, and Rebecca M. Sappington. “Internalization of Angiotensin-(1-12) in Adult Retinal Pigment Epithelial-19 Cells.” Faseb J 36 Suppl 1 (May 2022). https://doi.org/10.1096/fasebj.2022.36.S1.L7802.
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    • Parmar, Tanu, Mayur Choudhary, and Goldis Malek. “Potential Mechanisms of NUR77-Mediated Signaling in the Aging Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration.” Faseb J 36 Suppl 1 (May 2022). https://doi.org/10.1096/fasebj.2022.36.S1.0R261.
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    • Lekwuwa, Michael, Mayur Choudhary, Eleonora M. Lad, and Goldis Malek. “Osteopontin accumulates in basal deposits of human eyes with age-related macular degeneration and may serve as a biomarker of aging.” Mod Pathol 35, no. 2 (February 2022): 165–76. https://doi.org/10.1038/s41379-021-00887-7.
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    • Pilgrim, Matthew G., Salma Marouf, Sarah Fearn, Lajos Csincsik, Elod Kortvely, Jonathan C. Knowles, Goldis Malek, Richard B. Thompson, and Imre Lengyel. “Characterization of Calcium Phosphate Spherical Particles in the Subretinal Pigment Epithelium-Basal Lamina Space in Aged Human Eyes.” Ophthalmol Sci 1, no. 3 (September 2021): 100053. https://doi.org/10.1016/j.xops.2021.100053.
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    • Malek, Goldis. “15th Biennial AOPT Scientific Meeting: Restoring Vision Through Regeneration Virtual Meeting, March 4th-7th, 2021.” J Ocul Pharmacol Ther 36, no. 10 (December 2020): 713–14. https://doi.org/10.1089/jop.2020.0136.
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    • Choudhary, Mayur, and Goldis Malek. “The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for Ocular and Non-Ocular Neurodegenerative Diseases.” Int J Mol Sci 21, no. 18 (September 16, 2020). https://doi.org/10.3390/ijms21186777.
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    • Peavey, Jeremy, and Goldis Malek. “Cell Line Authentication in Vision Research and Beyond: A Tale Retold.” Invest Ophthalmol Vis Sci 61, no. 6 (June 3, 2020): 19. https://doi.org/10.1167/iovs.61.6.19.
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    • Yao, Pei-Li, Jeremy Peavey, and Goldis Malek. “Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases.” Int J Mol Sci 21, no. 8 (April 21, 2020). https://doi.org/10.3390/ijms21082889.
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    • Choudhary, Mayur, Ebraheim N. Ismail, Pei-Li Yao, Faryan Tayyari, Roxana A. Radu, Steven Nusinowitz, Michael E. Boulton, et al. “LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target.” Jci Insight 5, no. 1 (January 16, 2020). https://doi.org/10.1172/jci.insight.131928.
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    • Hadziahmetovic, Majda, and Goldis Malek. “Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies.” Front Cell Dev Biol 8 (2020): 612812. https://doi.org/10.3389/fcell.2020.612812.
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    • Choudhary, Mayur, and Goldis Malek. “A Review of Pathogenic Drivers of Age-Related Macular Degeneration, Beyond Complement, with a Focus on Potential Endpoints for Testing Therapeutic Interventions in Preclinical Studies.” Adv Exp Med Biol 1185 (2019): 9–13. https://doi.org/10.1007/978-3-030-27378-1_2.
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    • Ban, Norimitsu, Tae Jun Lee, Abdoulaye Sene, Mayur Choudhary, Michael Lekwuwa, Zhenyu Dong, Andrea Santeford, et al. “Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss.” Jci Insight 3, no. 17 (September 6, 2018). https://doi.org/10.1172/jci.insight.120824.
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    • Choudhary, Mayur, Stephen Safe, and Goldis Malek. “Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor.” Biochim Biophys Acta Mol Basis Dis 1864, no. 5 Pt A (May 2018): 1583–95. https://doi.org/10.1016/j.bbadis.2018.02.015.
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    • Malek, Goldis, Julia Busik, Maria B. Grant, and Mayur Choudhary. “Models of retinal diseases and their applicability in drug discovery.” Expert Opin Drug Discov 13, no. 4 (April 2018): 359–77. https://doi.org/10.1080/17460441.2018.1430136.
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    • Ismail, Ebraheim N., Jeffrey W. Ruberti, and Goldis Malek. “Quick-freeze/deep-etch electron microscopy visualization of the mouse posterior pole.” Exp Eye Res 162 (September 2017): 62–72. https://doi.org/10.1016/j.exer.2017.06.013.
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    • Hammer, Sandra S., Eleni Beli, Nermin Kady, Qi Wang, Kiana Wood, Todd A. Lydic, Goldis Malek, et al. “The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor.” Ebiomedicine 22 (August 2017): 181–90. https://doi.org/10.1016/j.ebiom.2017.07.008.
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    • Choudhary, Mayur, and Goldis Malek. “Rethinking Nuclear Receptors as Potential Therapeutic Targets for Retinal Diseases.” J Biomol Screen 21, no. 10 (December 2016): 1007–18. https://doi.org/10.1177/1087057116659856.
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    • Choudhary, Mayur, Jin-Dong Ding, Xiaoping Qi, Michael E. Boulton, Pei-Li Yao, Jeffrey M. Peters, and Goldis Malek. “PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration.” Aging (Albany Ny) 8, no. 9 (September 8, 2016): 1952–78. https://doi.org/10.18632/aging.101031.
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    • Choudhary, Mayur, and Goldis Malek. “A Brief Discussion on Lipid Activated Nuclear Receptors and their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD).” Adv Exp Med Biol 854 (2016): 45–51. https://doi.org/10.1007/978-3-319-17121-0_7.
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    • Choudhary, Mayur, Dmitri Kazmin, Peng Hu, Russell S. Thomas, Donald P. McDonnell, and Goldis Malek. “Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways.” J Pathol 235, no. 1 (January 2015): 101–12. https://doi.org/10.1002/path.4433.
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    • Malek, Goldis. “Nuclear receptors as potential therapeutic targets for age-related macular degeneration.” Adv Exp Med Biol 801 (2014): 317–21. https://doi.org/10.1007/978-1-4614-3209-8_40.
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    • Espinosa-Heidmann, Diego G., Goldis Malek, Priyatham S. Mettu, Alejandro Caicedo, Peter Saloupis, Sarah Gach, Askia K. Dunnon, Peng Hu, Maria-Grazia Spiga, and Scott W. Cousins. “Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser-induced choroidal neovascularization.” Invest Ophthalmol Vis Sci 54, no. 12 (November 13, 2013): 7439–49. https://doi.org/10.1167/iovs.13-12546.
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    • Hu, Peng, Rolf Herrmann, Amanda Bednar, Peter Saloupis, Mary A. Dwyer, Ping Yang, Xiaoping Qi, et al. “Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology.” Proc Natl Acad Sci U S A 110, no. 43 (October 22, 2013): E4069–78. https://doi.org/10.1073/pnas.1307574110.
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    • Malek, Goldis, Mary Dwyer, and Donald McDonnell. “Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD.” Adv Exp Med Biol 723 (2012): 51–59. https://doi.org/10.1007/978-1-4614-0631-0_8.
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    • Dwyer, Mary A., Dmitri Kazmin, Peng Hu, Donald P. McDonnell, and Goldis Malek. “Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration.” Mol Endocrinol 25, no. 2 (February 2011): 360–72. https://doi.org/10.1210/me.2010-0392.
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    • Anderson, Don H., Monte J. Radeke, Natasha B. Gallo, Ethan A. Chapin, Patrick T. Johnson, Christy R. Curletti, Lisa S. Hancox, et al. “The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.” Prog Retin Eye Res 29, no. 2 (March 2010): 95–112. https://doi.org/10.1016/j.preteyeres.2009.11.003.
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    • Zweifel, Sandrine A., Richard F. Spaide, Christine A. Curcio, Goldis Malek, and Yutaka Imamura. “Reticular pseudodrusen are subretinal drusenoid deposits.” Ophthalmology 117, no. 2 (February 2010): 303-12.e1. https://doi.org/10.1016/j.ophtha.2009.07.014.
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    • Malek, Goldis, Peng Hu, Albert Wielgus, Mary Dwyer, and Scott Cousins. “PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration.” Adv Exp Med Biol 664 (2010): 429–36. https://doi.org/10.1007/978-1-4419-1399-9_49.
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    • Rudolf, Martin, Goldis Malek, Jeffrey D. Messinger, Mark E. Clark, Lan Wang, and Christine A. Curcio. “Sub-retinal drusenoid deposits in human retina: organization and composition.” Exp Eye Res 87, no. 5 (November 2008): 402–8. https://doi.org/10.1016/j.exer.2008.07.010.
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    • Malek, Goldis, Jeffery A. Jamison, Brian Mace, Patrick Sullivan, and Catherine Bowes Rickman. “ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration.” Adv Exp Med Biol 613 (2008): 165–70. https://doi.org/10.1007/978-0-387-74904-4_18.
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    • Yu, Ling, Una Kelly, Jessica N. Ebright, Goldis Malek, Peter Saloupis, Dennis W. Rickman, Brian S. McKay, Vadim Y. Arshavsky, and Catherine Bowes Rickman. “Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina.” Biochim Biophys Acta 1773, no. 9 (September 2007): 1473–82. https://doi.org/10.1016/j.bbamcr.2007.06.005.
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    • Edwards, Albert O., and Goldis Malek. “Molecular genetics of AMD and current animal models.” Angiogenesis 10, no. 2 (2007): 119–32. https://doi.org/10.1007/s10456-007-9064-2.
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    • Curcio, Christine A., J Brett Presley, Goldis Malek, Nancy E. Medeiros, Dina V. Avery, and Howard S. Kruth. “Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy.” Exp Eye Res 81, no. 6 (December 2005): 731–41. https://doi.org/10.1016/j.exer.2005.04.012.
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    • Rosenthal, Rita, Goldis Malek, Nina Salomon, Mortiz Peill-Meininghaus, Linn Coeppicus, Hendrik Wohlleben, Soenke Wimmers, Catherine Bowes Rickman, and Olaf Strauss. “The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells.” Biochem Biophys Res Commun 337, no. 1 (November 11, 2005): 241–47. https://doi.org/10.1016/j.bbrc.2005.09.028.
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    • Malek, G., L. V. Johnson, B. E. Mace, P. Saloupis, D. E. Schmechel, D. W. Rickman, C. A. Toth, P. M. Sullivan, and C. Bowes Rickman. “Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.” Proc Natl Acad Sci U S A 102, no. 33 (August 16, 2005): 11900–905. https://doi.org/10.1073/pnas.0503015102.
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    • Li, Chuan-Ming, Byung Hong Chung, J Brett Presley, Goldis Malek, Xueming Zhang, Nassrin Dashti, Ling Li, et al. “Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization.” Invest Ophthalmol Vis Sci 46, no. 7 (July 2005): 2576–86. https://doi.org/10.1167/iovs.05-0034.
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    • Rosenthal, Rita, Hendrik Wohlleben, Goldis Malek, Lars Schlichting, Hagen Thieme, Catherine Bowes Rickman, and Olaf Strauss. “Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration.” Biochem Biophys Res Commun 323, no. 4 (October 29, 2004): 1203–8. https://doi.org/10.1016/j.bbrc.2004.08.219.
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    • Malek, Goldis, Chuan-Ming Li, Clyde Guidry, Nancy E. Medeiros, and Christine A. Curcio. “Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy.” Am J Pathol 162, no. 2 (February 2003): 413–25. https://doi.org/10.1016/S0002-9440(10)63836-9.
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    • Milam, A. H., C. A. Curcio, A. V. Cideciyan, S. Saxena, S. K. John, H. S. Kruth, G. Malek, J. R. Heckenlively, R. G. Weleber, and S. G. Jacobson. “Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration.” Ophthalmology 107, no. 12 (December 2000): 2256–66. https://doi.org/10.1016/s0161-6420(00)00419-x.
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    • Curcio, C. A., P. L. Saunders, P. W. Younger, and G. Malek. “Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss.” Ophthalmology 107, no. 2 (February 2000): 334–43. https://doi.org/10.1016/s0161-6420(99)00037-8.
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    • Milam, A. H., C. A. Curcio, A. V. Cideciyan, S. Saxena, S. K. John, H. S. Kruth, G. Malek, J. R. Heckenlively, R. G. Weleber, and S. G. Jacobson. “Evaluation of the onset and duration of effect of azelastine eye drops (0.05%) versus placebo in patients with allergic conjunctivitis using an allergen challenge model.” Ophthalmology 107, no. 12 (2000): 2152–57. https://doi.org/10.1016/S0161-6420(00)00349-3.
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  • Book Sections

    • Malek, G., P. L. Yao, and M. Choudhary. “Models of pathologies associated with age-related macular degeneration and their utilities in drug discovery.” In Topics in Medicinal Chemistry, 35:83–123, 2020. https://doi.org/10.1007/7355_2020_93.
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    • Malek, Goldis, Brian Mace, Peter Saloupis, Donald Schmechel, Dennis Rickman, Patrick Sullivan, and Catherine Bowes Rickman. “Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice.,” 572:109–17, 2006. https://doi.org/10.1007/0-387-32442-9_17.
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  • Other Articles

    • Malek, G., and S. W. Cousins. “Is our current clinical classification of AMD up to the job?” Br J Ophthalmol, September 2006. https://doi.org/10.1136/bjo.2006.098715.
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  • Conference Papers

    • Choudhary, Mayur, and Goldis Malek. “Identification of disease associated endpoints in a mouse model exhibiting AMD-like pathology with age.” In Investigative Ophthalmology & Visual Science, Vol. 63, 2022.
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    • Malek, Goldis, Vipul Parmar, and Jeremy Peavey. “Nuclear Receptor Atlas of the Choroid: Implications for Disease.” In Investigative Ophthalmology & Visual Science, Vol. 63, 2022.
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    • Parmar, Tanu, and Goldis Malek. “Morphological and functional effects of nicotinamide on primary RPE cells derived from old donors.” In Investigative Ophthalmology & Visual Science, Vol. 63, 2022.
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    • Choudhary, Mayur, and Goldis Malek. “Aryl hydrocarbon receptor (AHR): potential link between autophagy and inflammation in retinal pigment epithelial (RPE) cells.” In Investigative Ophthalmology & Visual Science, Vol. 62, 2021.
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    • Peavey, Jeremy Jacob, and Goldis Malek. “Nuclear Receptor Atlas of Human Choroidal Endothelium.” In Investigative Ophthalmology & Visual Science, Vol. 61, 2020.
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    • Yao, Pei-Li, Mayur Choudhary, Michael Lekwuwa, and Goldis Malek. “Subchronic Fatty Diet Exacerbates Age-Related Macular Degneration (AMD) Phenotypes Associated with Impaired LXRa Signaling.” In Investigative Ophthalmology & Visual Science, Vol. 61, 2020.
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    • Ding, Xi-Qin, Fan Yang, Michael Robert Butler, Goldis Malek, and Hongwei Ma. “Thyroid Hormone Regulation of Retinal Pigment Epithelium Morphology and Survival.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.
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    • Malek, Goldis, and Pei-Li Yao. “Cooperative roles of NURR1 with RXR and LXR in retinal pigment epithelial (RPE) cells varies as a function of age and aged-related macular degeneration (AMD).” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.
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    • Choudhary, Mayur, Faryan Tayyari, James T. Handa, and Goldis Malek. “Identification of endpoints appropriate in evaluating potential therapeutics for retinal degenerations using apoB100 transgenic mice.” In Investigative Ophthalmology & Visual Science, Vol. 59. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2018.
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    • Choudhary, Mayur, Stephen H. Safe, and Goldis Malek. “Aryl hydrocarbon receptor (AhR) activation decreases severity of laser-induced choroidal neovascular lesions (CNV).” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
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    • Hammer, Sandra, Todd Lydic, Qi Wang, Sugata Hazra, Goldis Malek, Michael E. Boulton, Maria B. Grant, and Julia V. Busik. “Downregulation of the SIRT1 and Liver X Receptor alpha/beta signaling axis promotes diabetic retinopathy pathogenesis.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
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    • Tayyari, Faryan, Mayur Choudhary, Peter Tontonoz, James T. Handa, and Goldis Malek. “Evaluating the efficacy of treatment with an LXR agonist on the pathogenesis of early AMD.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
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    • Choudhary, Mayur, Jeffrey Peters, and Goldis Malek. “Investigating the role of peroxisome proliferator-activated receptor-beta/delta (PPAR beta/delta) in wet age-related macular degeneration (AMD).” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
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    • Malek, Goldis, Faryan Tayyari, Mayur Choudhary, Yiyi Wang, Zhichun Liang, Steven Nusinowitz, Roxana A. Radu, and Peter Tontonoz. “Liver x receptors (LXR) at the intersection of lipid metabolism and inflammation: implications for age-related macular degeneration (AMD).” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
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    • Choudhary, Mayur, Lincoln V. Johnson, David Forest, Xiaoping Qi, Michael E. Boulton, and Goldis Malek. “Targeting the peroxisome proliferator-activated receptor beta/delta ( PPAR beta/delta): Implications for dry and wet age-related macular degeneration (AMD).” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
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    • Ismail, Ebraheim, Jeffrey Ruberti, and Goldis Malek. “Evaluation of the morphology of the mouse retinal pigment epithelium/bruch's membrane/choroid (RPE/BrM/Ch) using quick-freeze, deepetch transmission electron microscopy (QFDE-TEM) and conventional (cTEM).” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
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    • Malek, Goldis, Mayur Choudhary, David Forest, Lincoln V. Johnson, and Stephen H. Safe. “The effect of pharmacologic activation of the aryl hydrocarbon receptor (AhR) on pathologies associated with age-related macular degeneration (AMD).” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
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    • Choudhary, Mayur, and Goldis Malek. “Peroxisome proliferator-activated receptor (PPAR) beta/delta expression and activation in retinal pigment epithelial and choroidal endothelial cells: implication in age-related macular degeneration.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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    • Malek, Goldis, Mayur Choudhary, Edwin Meade, Erik Nelson, and Donald McDonnell. “Liver X Receptor signaling pathways and age-related macular degeneration.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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    • Bednar, Amanda, Mayur Choudhary, Peter Saloupis, Alan Proia, and Goldis Malek. “Osteopontin (OPN) is Present in Drusen and Basal Deposits in Human Eyes with Age-Related Macular Degeneration (AMD).” In Investigative Ophthalmology & Visual Science, Vol. 54. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013.
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    • Choudhary, Mayur, Amanda Bednar, Peter Saloupis, Peng Hu, and Goldis Malek. “Aryl-hydrocarbon receptor plays a role in choroidal neovascularization by regulating endothelial migration and tube formation.” In Investigative Ophthalmology & Visual Science, Vol. 54. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013.
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    • Hu, Peng, Alfredo Caro-Maldonado, Jeffrey Rathmell, and Goldis Malek. “Exploring Potential Differences in the Cell Energy Metabolism of Retinal Pigment Epithelial (RPE) Cell Culture Models.” In Investigative Ophthalmology & Visual Science, Vol. 54. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013.
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    • Dunnon, A. K., P. Saloupis, T. Pridgen, K. Wu, G. Malek, and S. W. Cousins. “Different Patterns of Neovascularization Are Determined by Different Pro-Angiogenic Stimuli.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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    • Dwyer, M., D. P. McDonnell, P. Hu, S. Cousins, and G. Malek. “Oxidant Activation of the Transcription Factor Aryl Hydrocarbon Receptor Effects Mitochondrial Function in Retinal Pigment Epithelial Cells.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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    • Espinosa-Heidmann, D. G., G. Malek, K. Wu, P. Saloupis, and S. W. Cousins. “Osteopontin Regulation of Choroidal Neovascular Fibrosis Through Macrophages.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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    • Malek, G., P. Hu, M. Dwyer, S. W. Cousins, and D. P. McDonnell. “Expression Profiling of Nuclear Receptors in Human Retinal Pigment Epithelial Cells: Relevance to Age-Related Macular Degeneration.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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    • Wielgus, A. R., S. W. Cousins, and G. Malek. “Effects of Sub-Lethal Levels of Omega-3 and-6 Polyunsaturated Fatty Acid Oxidation End Products in RPE Cell Culture.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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    • Malek, G., B. Mace, P. Saloupis, D. Schmechel, D. Rickman, P. Sullivan, and C. B. Rickman. “Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice - For contributed volumes.” In Retinal Degenerative Diseases, 572:109–17, 2006.
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    • Malek, G., P. Saloupis, B. Mace, D. Schmechel, D. Rickman, P. Sullivan, and C. B. Rickman. “Characterization of the natural history of neovascularization and basal deposits in a non-invasive murine model of age-related macular degeneration.” In Investigative Ophthalmology & Visual Science, Vol. 46. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2005.
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    • Walsh, M. M., G. Malek, P. Saloupis, P. M. Sullivan, B. Mace, D. E. Schmechel, C. B. Rickman, and D. W. Rickman. “Apolipoprotein (APOE) allelic expression, advanced age, and diet contribute to atrophic degenerative changes in retinal ganglion cells and optic nerve in a mouse model: Predictors of severity of glaucoma?” In Investigative Ophthalmology & Visual Science, Vol. 46. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2005.
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    • Yu, L., U. Kelly, J. N. Ebright, G. Malek, B. S. McKay, and C. B. Rickman. “Light dependent membrane association of PRL-1, a phosphatase expressed in cone photoreceptors.” In Investigative Ophthalmology & Visual Science, Vol. 46. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2005.
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    • Zavodni, Z. J., J. N. Ebright, G. Malek, R. W. Storms, and C. B. Rickman. “Challenges of human RPE gene profiling.” In Investigative Ophthalmology & Visual Science, Vol. 46. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2005.
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    • Malek, G., P. Saloupis, B. Mace, D. Schmechel, P. Sullivan, and C. B. Rickman. “Murine choroidal neovascularization: A model for exudative age-related macular degeneration (AMD).” In Investigative Ophthalmology & Visual Science, 45:U731–U731. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.
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    • Yu, L., U. Kelly, J. N. Ebright, G. Malek, B. S. McKay, and C. B. Rickman. “Characterization of PRL-1, a human cone photoreceptor protein tyrosine phosphatase.” In Investigative Ophthalmology & Visual Science, 45:U529–U529. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.
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    • Malek, G., P. M. Sullivan, B. E. Mace, D. Schmechel, and C. B. Rickman. “Effect of diet and targeted replacement human APOE isoforms in aged mice.” In Investigative Ophthalmology & Visual Science, 44:U405–U405. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2003.
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• Teaching & Mentoring
• 

  Recent Courses

  • PATHOL 293: Research Independent Study 2023
  • PATHOL 787: Basic Biology of Cells as a Function of Age; Implication for Disease 2023
  • PATHOL 293: Research Independent Study 2022
  • PATHOL 787: Basic Biology of Cells as a Function of Age; Implication for Disease 2022
  • PATHOL 793: Research Independent Study 2022
  • PATHOL 787: Basic Biology of Cells as a Function of Age; Implication for Disease 2021
  • PATHOL 793: Research Independent Study 2021
• 

  Teaching Activities

  • Course co-director and co-organizer for PATHOL 787: Basic Biology of Cells as a Function of Age; Implication for Disease.

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