Regulation of T-helper-cell lineage development by osteopontin: the inside story.
Publication
, Journal Article
Cantor, H; Shinohara, ML
Published in: Nat Rev Immunol
February 2009
Studies of osteopontin (OPN)-dependent regulation of immune responses have focused on the cytokine activities of the secreted form of this protein. Recent evidence has revealed that an intracellular form of OPN expressed by dendritic cells regulates the expression of pro-inflammatory cytokines and the differentiation of T helper (T(H))-cell lineages. In this Opinion article, we discuss the properties of both OPN isoforms and their respective contributions to the immune response. We propose that cell-type-specific expression of secreted and intracellular OPN regulates the development of distinct effector T(H) cells, including that of T(H)1 and T(H)17 cells.
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Published In
Nat Rev Immunol
DOI
EISSN
1474-1741
Publication Date
February 2009
Volume
9
Issue
2
Start / End Page
137 / 141
Location
England
Related Subject Headings
- Virus Diseases
- Th1 Cells
- T-Lymphocytes, Helper-Inducer
- Osteopontin
- Macrophages
- Lymphopoiesis
- Lymphocyte Activation
- Interleukin-17
- Immunology
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Cantor, H., & Shinohara, M. L. (2009). Regulation of T-helper-cell lineage development by osteopontin: the inside story. Nat Rev Immunol, 9(2), 137–141. https://doi.org/10.1038/nri2460
Cantor, Harvey, and Mari L. Shinohara. “Regulation of T-helper-cell lineage development by osteopontin: the inside story.” Nat Rev Immunol 9, no. 2 (February 2009): 137–41. https://doi.org/10.1038/nri2460.
Cantor H, Shinohara ML. Regulation of T-helper-cell lineage development by osteopontin: the inside story. Nat Rev Immunol. 2009 Feb;9(2):137–41.
Cantor, Harvey, and Mari L. Shinohara. “Regulation of T-helper-cell lineage development by osteopontin: the inside story.” Nat Rev Immunol, vol. 9, no. 2, Feb. 2009, pp. 137–41. Pubmed, doi:10.1038/nri2460.
Cantor H, Shinohara ML. Regulation of T-helper-cell lineage development by osteopontin: the inside story. Nat Rev Immunol. 2009 Feb;9(2):137–141.
Published In
Nat Rev Immunol
DOI
EISSN
1474-1741
Publication Date
February 2009
Volume
9
Issue
2
Start / End Page
137 / 141
Location
England
Related Subject Headings
- Virus Diseases
- Th1 Cells
- T-Lymphocytes, Helper-Inducer
- Osteopontin
- Macrophages
- Lymphopoiesis
- Lymphocyte Activation
- Interleukin-17
- Immunology
- Humans