Regulation of T-helper-cell lineage development by osteopontin: the inside story.

Journal Article (Review)

Studies of osteopontin (OPN)-dependent regulation of immune responses have focused on the cytokine activities of the secreted form of this protein. Recent evidence has revealed that an intracellular form of OPN expressed by dendritic cells regulates the expression of pro-inflammatory cytokines and the differentiation of T helper (T(H))-cell lineages. In this Opinion article, we discuss the properties of both OPN isoforms and their respective contributions to the immune response. We propose that cell-type-specific expression of secreted and intracellular OPN regulates the development of distinct effector T(H) cells, including that of T(H)1 and T(H)17 cells.

Full Text

Duke Authors

Cited Authors

  • Cantor, H; Shinohara, ML

Published Date

  • February 2009

Published In

Volume / Issue

  • 9 / 2

Start / End Page

  • 137 - 141

PubMed ID

  • 19096390

Pubmed Central ID

  • PMC2696694

Electronic International Standard Serial Number (EISSN)

  • 1474-1741

Digital Object Identifier (DOI)

  • 10.1038/nri2460


  • eng

Conference Location

  • England