Mari L. Shinohara | Scholars@Duke

Mari L. Shinohara
Professor of Integrative Immunobiology

Shinohara Lab Website

Immune responses against pathogens are essential for host protection, but excessive and uncontrolled immune reactions can lead to autoimmunity. How does our immune system keep the balance fine-tuned? This is a central question being asked in my laboratory.

The immune system needs to detect pathogens quickly and effectively. This is performed by the innate immune system, which includes cells such as macrophages and dendritic cells (DCs). Pathogens are recognized by pattern recognition receptors (PRRs) and may be cleared in the innate immune system. However, when pathogens cannot be eliminated by innate immunity, the adaptive immune system participates by exploiting the ability of T cells and B cells. The two immune systems work together not only to clear pathogens effectively but also to avoid collateral damages by our own immune responses.

In my lab, we use mouse models for infectious and autoimmune diseases to understand the cellular and molecular mechanisms of; pathogen recognition by PRRs in macrophages and DCs, initiation of inflammatory responses in the innate immune system, and the impact of innate immune inflammation on the development and regulation of T cell-mediated adaptive immune responses.

Several projects are ongoing in the lab. They are to study (1) the roles of PRR in EAE (an animal model of multiple sclerosis), (2) the interplay between immune cells and CNS (central nervous system)-resident cells during EAE and fungal infection, (3) protective and pathogenic mechanisms of immune cells in the lung during fungal infection and inflammation, and (4) the roles of a protein termed osteopontin (OPN), as both secreted (sOPN) and intracellular (iOPN) isoforms, in regulation of immune responses . Although we are very active in EAE to study autoimmunity, other mouse models, such as graft-versus-host disease (GvHD) is ongoing. Cell types we study are mainly DCs, macrophages, neutrophils, and T cells.

Current Appointments & Affiliations

Professor of Integrative Immunobiology, Integrative Immunobiology, Basic Science Departments 2023
Director of Graduate Studies in the Department of Immunology, Integrative Immunobiology, Basic Science Departments 2018
Associate Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2017
Associate Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2009
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2020

Contact Information

338JONES Building, 207 Researc, Box 3010 Dumc, Dept of Immunology, Durham, NC 27710
Box 3010 DUMC, 338 Jones Building, Durham, NC 27710
mari.shinohara@duke.edu (919) 613-6977
Lab Website
Twitter

Background
Leadership & Clinical Positions at Duke
- Director of Graduate Studies in Immunology
Expertise
Subject Headings
Research
External Relationships
- Department of Microbiology & Immunology, Dartmouth College
- FWF Austrian Science Fund/Medical University of Vienna
- Kindai University
- Kyoto University
- Ono pharma USA, Inc.
- Osaka University
- Tellus Therapeutics, Inc.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lin, Elliot Yi-Hsin, Wen Xi, Nupur Aggarwal, and Mari L. Shinohara. “Osteopontin (OPN)/SPP1: from its biochemistry to biological functions in the innate immune system and the central nervous system (CNS).” Int Immunol 35, no. 4 (April 4, 2023): 171–80. https://doi.org/10.1093/intimm/dxac060.
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  - Jiang, Yike, and Mari L. Shinohara. “Microglia C-lectin/selectin' neurons to eat.” Immunity 56, no. 2 (February 14, 2023): 227–29. https://doi.org/10.1016/j.immuni.2023.01.020.
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  - Deerhake, M Elizabeth, Emre D. Cardakli, and Mari L. Shinohara. “Dectin-1 signaling in neutrophils up-regulates PD-L1 and triggers ROS-mediated suppression of CD4+ T cells.” J Leukoc Biol 112, no. 6 (December 2022): 1413–25. https://doi.org/10.1002/JLB.3A0322-152RR.
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  - Ratiu, Jeremy J., William E. Barclay, Elliot Lin, Qun Wang, Sebastian Wellford, Naren Mehta, Melissa J. Harnois, et al. “Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes.” Nat Commun 13, no. 1 (October 6, 2022): 5901. https://doi.org/10.1038/s41467-022-33610-4.
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  - Reyes, Estefany Y., and Mari L. Shinohara. “Host immune responses in the central nervous system during fungal infections.” Immunol Rev 311, no. 1 (October 2022): 50–74. https://doi.org/10.1111/imr.13101.
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  - Whitson, Heather E., Carol Colton, Joseph El Khoury, David Gate, Alison Goate, Michael T. Heneka, Rima Kaddurah-Daouk, et al. “Infection and inflammation: New perspectives on Alzheimer's disease.” Brain Behav Immun Health 22 (July 2022): 100462. https://doi.org/10.1016/j.bbih.2022.100462.
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  - Barclay, William E., Nupur Aggarwal, M Elizabeth Deerhake, Makoto Inoue, Toshiaki Nonaka, Kengo Nozaki, Nathan A. Luzum, Edward A. Miao, and Mari L. Shinohara. “The AIM2 inflammasome is activated in astrocytes during the late phase of EAE.” Jci Insight 7, no. 8 (April 22, 2022). https://doi.org/10.1172/jci.insight.155563.
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  - Zhang, Zhiquan, Qing Ma, Ravikanth Velagapudi, William E. Barclay, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Mari L. Shinohara, and Niccolò Terrando. “Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome.” Front Immunol 13 (2022): 856254. https://doi.org/10.3389/fimmu.2022.856254.
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  - Aggarwal, Nupur, M Elizabeth Deerhake, Devon DiPalma, Shailesh K. Shahi, Margaret R. Gaggioli, Ashutosh K. Mangalam, and Mari L. Shinohara. “Secreted osteopontin from CD4+ T cells limits acute graft-versus-host disease.” Cell Rep 37, no. 13 (December 28, 2021): 110170. https://doi.org/10.1016/j.celrep.2021.110170.
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  - Barclay, William E., M Elizabeth Deerhake, Makoto Inoue, Toshiaki Nonaka, Kengo Nozaki, Nathan A. Luzum, Nupur Aggarwal, Edward A. Miao, and Mari L. Shinohara. “AIM2 inflammasome activation in astrocytes occurs during the late phase of EAE,” October 5, 2021. https://doi.org/10.1101/2021.10.03.462457.
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  - Deerhake, M Elizabeth, and Mari L. Shinohara. “Emerging roles of Dectin-1 in noninfectious settings and in the CNS.” Trends Immunol 42, no. 10 (October 2021): 891–903. https://doi.org/10.1016/j.it.2021.08.005.
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  - Lünemann, Jan D., Sunny Malhotra, Mari L. Shinohara, Xavier Montalban, and Manuel Comabella. “Targeting Inflammasomes to Treat Neurological Diseases.” Ann Neurol 90, no. 2 (August 2021): 177–88. https://doi.org/10.1002/ana.26158.
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  - Deerhake, M Elizabeth, Keiko Danzaki, Makoto Inoue, Emre D. Cardakli, Toshiaki Nonaka, Nupur Aggarwal, William E. Barclay, Ru-Rong Ji, and Mari L. Shinohara. “Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M.” Immunity 54, no. 3 (March 9, 2021): 484-498.e8. https://doi.org/10.1016/j.immuni.2021.01.004.
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  - Deerhake, M Elizabeth, Estefany Y. Reyes, Shengjie Xu-Vanpala, and Mari L. Shinohara. “Single-Cell Transcriptional Heterogeneity of Neutrophils During Acute Pulmonary Cryptococcus neoformans Infection.” Front Immunol 12 (2021): 670574. https://doi.org/10.3389/fimmu.2021.670574.
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  - Liang, Jie, Junyi J. Zhang, Hsin-I Huang, Masashi Kanayama, Nourhan Youssef, Yingai J. Jin, Estefany Y. Reyes, et al. “The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection.” Infect Immun 88, no. 9 (August 19, 2020). https://doi.org/10.1128/IAI.00048-20.
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  - Xu-Vanpala, Shengjie, M Elizabeth Deerhake, Joshua D. Wheaton, Morgan E. Parker, Praveen R. Juvvadi, Nancie MacIver, Maria Ciofani, and Mari L. Shinohara. “Functional heterogeneity of alveolar macrophage population based on expression of CXCL2.” Sci Immunol 5, no. 50 (August 7, 2020). https://doi.org/10.1126/sciimmunol.aba7350.
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  - Thak, Eun Jung, Su-Bin Lee, Shengjie Xu-Vanpala, Dong-Jik Lee, Seung-Yeon Chung, Yong-Sun Bahn, Doo-Byoung Oh, Mari L. Shinohara, and Hyun Ah Kang. “Core N-Glycan Structures Are Critical for the Pathogenicity of Cryptococcus neoformans by Modulating Host Cell Death.” Mbio 11, no. 3 (May 12, 2020). https://doi.org/10.1128/mBio.00711-20.
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  - Ide, Shintaro, Yasuhito Yahara, Yoshihiko Kobayashi, Sarah A. Strausser, Kana Ide, Anisha Watwe, Shengjie Xu-Vanpala, et al. “Yolk-sac-derived macrophages progressively expand in the mouse kidney with age.” Elife 9 (April 17, 2020). https://doi.org/10.7554/eLife.51756.
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  - Khaw, Yee Ming, Nupur Aggarwal, William E. Barclay, Eunjoo Kang, Makoto Inoue, and Mari L. Shinohara. “Th1-Dependent Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome Model With Brain Damage.” Front Immunol 11 (2020): 529219. https://doi.org/10.3389/fimmu.2020.529219.
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  - Yahara, Yasuhito, Tomasa Barrientos, Yuning J. Tang, Vijitha Puviindran, Puviindran Nadesan, Hongyuan Zhang, Jason R. Gibson, et al. “Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair.” Nat Cell Biol 22, no. 1 (January 2020): 49–59. https://doi.org/10.1038/s41556-019-0437-8.
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  - Deerhake, M Elizabeth, Debolina D. Biswas, William E. Barclay, and Mari L. Shinohara. “Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models.” Front Immunol 10 (2019): 2644. https://doi.org/10.3389/fimmu.2019.02644.
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  - Deerhake, M Elizabeth, William E. Barclay, and Mari L. Shinohara. “Are Neuropeptide-Reactive T Cells behind Narcolepsy?” Immunity 49, no. 5 (November 20, 2018): 796–98. https://doi.org/10.1016/j.immuni.2018.11.002.
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  - Aggarwal, Nupur, William Barclay, and Mari L. Shinohara. “Understanding mechanisms underlying the pathology of immune reconstitution inflammatory syndrome (IRIS) by using animal models.” Curr Clin Microbiol Rep 5, no. 3 (September 2018): 201–9. https://doi.org/10.1007/s40588-018-0099-5.
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  - Kanayama, Masashi, Shengjie Xu, Keiko Danzaki, Jason R. Gibson, Makoto Inoue, Simon G. Gregory, and Mari L. Shinohara. “Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.” Nat Immunol 18, no. 9 (September 2017): 973–84. https://doi.org/10.1038/ni.3791.
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  - Shinohara, Mari L. “Yes, research matters.” Plos Pathog 13, no. 8 (August 2017): e1006420. https://doi.org/10.1371/journal.ppat.1006420.
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  - Singh, Nina, Makoto Inoue, Ryosuke Osawa, Marilyn M. Wagener, and Mari L. Shinohara. “Inflammasome expression and cytomegalovirus viremia in critically ill patients with sepsis.” J Clin Virol 93 (August 2017): 8–14. https://doi.org/10.1016/j.jcv.2017.05.012.
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  - Schmidt, Elyse A., Brian E. Fee, Stanley C. Henry, Amanda G. Nichols, Mari L. Shinohara, Jeffrey C. Rathmell, Nancie J. MacIver, et al. “Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages.” J Biol Chem 292, no. 11 (March 17, 2017): 4651–62. https://doi.org/10.1074/jbc.M116.770735.
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  - Barclay, William, and Mari L. Shinohara. “Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).” Brain Pathol 27, no. 2 (March 2017): 213–19. https://doi.org/10.1111/bpa.12477.
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  - Xu, Shengjie, and Mari L. Shinohara. “Tissue-Resident Macrophages in Fungal Infections.” Front Immunol 8 (2017): 1798. https://doi.org/10.3389/fimmu.2017.01798.
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  - Inoue, Makoto, Po-Han Chen, Stephen Siecinski, Qi-Jing Li, Chunlei Liu, Lawrence Steinman, Simon G. Gregory, Eric Benner, and Mari L. Shinohara. “An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage.” Nat Neurosci 19, no. 12 (December 2016): 1599–1609. https://doi.org/10.1038/nn.4421.
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  - Danzaki, Keiko, Masashi Kanayama, Oscar Alcazar, and Mari L. Shinohara. “Osteopontin has a protective role in prostate tumor development in mice.” Eur J Immunol 46, no. 11 (November 2016): 2669–78. https://doi.org/10.1002/eji.201646391.
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  - Kanayama, Masashi, Keiko Danzaki, You-Wen He, and Mari L. Shinohara. “Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis.” Int Immunol 28, no. 9 (September 2016): 463–69. https://doi.org/10.1093/intimm/dxw013.
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  - Gerriets, Valerie A., Keiko Danzaki, Rigel J. Kishton, William Eisner, Amanda G. Nichols, Donte C. Saucillo, Mari L. Shinohara, and Nancie J. MacIver. “Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity.” Eur J Immunol 46, no. 8 (August 2016): 1970–83. https://doi.org/10.1002/eji.201545861.
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  - Kanayama, Masashi, and Mari L. Shinohara. “Roles of Autophagy and Autophagy-Related Proteins in Antifungal Immunity.” Front Immunol 7 (2016): 47. https://doi.org/10.3389/fimmu.2016.00047.
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  - “Erratum.” Autophagy 12, no. 2 (2016): 443. https://doi.org/10.1080/15548627.2016.1147886.
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  - Inoue, Makoto, and Mari L. Shinohara. “Hyperinflammation, T cells, and endotoxemia.” Oncotarget 6, no. 27 (September 15, 2015): 23040–41. https://doi.org/10.18632/oncotarget.5236.
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  - Inoue, Makoto, and Mari L. Shinohara. “[NLRP3 inflammasome and multiple sclerosis/EAE].” Nihon Rinsho 73 Suppl 7 (September 2015): 835–41.
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  - Lee, Soo Chan, Alicia Li, Silvia Calo, Makoto Inoue, Nam K. Tonthat, Judith M. Bain, Johanna Louw, et al. “Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides.” Mol Microbiol 97, no. 5 (September 2015): 844–65. https://doi.org/10.1111/mmi.13071.
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  - Inoue, Makoto, and Mari L. Shinohara. “Cutting edge: Role of osteopontin and integrin αv in T cell-mediated anti-inflammatory responses in endotoxemia.” J Immunol 194, no. 12 (June 15, 2015): 5595–98. https://doi.org/10.4049/jimmunol.1500623.
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  - Kanayama, Masashi, You-Wen He, and Mari L. Shinohara. “The lung is protected from spontaneous inflammation by autophagy in myeloid cells.” J Immunol 194, no. 11 (June 1, 2015): 5465–71. https://doi.org/10.4049/jimmunol.1403249.
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  - Macosko, Evan Z., Anindita Basu, Rahul Satija, James Nemesh, Karthik Shekhar, Melissa Goldman, Itay Tirosh, et al. “Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets.” Cell 161, no. 5 (May 21, 2015): 1202–14. https://doi.org/10.1016/j.cell.2015.05.002.
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  - Heneka, Michael T., Monica J. Carson, Joseph El Khoury, Gary E. Landreth, Frederic Brosseron, Douglas L. Feinstein, Andreas H. Jacobs, et al. “Neuroinflammation in Alzheimer's disease.” Lancet Neurol 14, no. 4 (April 2015): 388–405. https://doi.org/10.1016/S1474-4422(15)70016-5.
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  - Kanayama, Masashi, Makoto Inoue, Keiko Danzaki, Gianna Hammer, You-Wen He, and Mari L. Shinohara. “Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity.” Nat Commun 6 (January 22, 2015): 5779. https://doi.org/10.1038/ncomms6779.
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  - Gerriets, Valerie A., Rigel J. Kishton, Amanda G. Nichols, Andrew N. Macintyre, Makoto Inoue, Olga Ilkayeva, Peter S. Winter, et al. “Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.” J Clin Invest 125, no. 1 (January 2015): 194–207. https://doi.org/10.1172/JCI76012.
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  - Inoue, Makoto, Tomohiro Arikawa, Yu-Hsun Chen, Yasuhiro Moriwaki, Michael Price, Michael Brown, John R. Perfect, and Mari L. Shinohara. “T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation.” Proc Natl Acad Sci U S A 111, no. 14 (April 8, 2014): 5295–5300. https://doi.org/10.1073/pnas.1321427111.
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  - Wang, Bin, Yan-Hua Rao, Makoto Inoue, Rui Hao, Chun-Hsiang Lai, David Chen, Stacey L. McDonald, et al. “Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production.” Nat Commun 5 (March 17, 2014): 3479. https://doi.org/10.1038/ncomms4479.
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  - Inoue, Makoto, and Mari L. Shinohara. “Clustering of pattern recognition receptors for fungal detection.” Plos Pathog 10, no. 2 (February 2014): e1003873. https://doi.org/10.1371/journal.ppat.1003873.
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  - Inoue, Makoto, and Mari L. Shinohara. “The role of interferon-β in the treatment of multiple sclerosis and experimental autoimmune encephalomyelitis - in the perspective of inflammasomes.” Immunology 139, no. 1 (May 2013): 11–18. https://doi.org/10.1111/imm.12081.
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  - Gorentla, Balachandra K., Sruti Krishna, Jinwook Shin, Makoto Inoue, Mari L. Shinohara, Jason M. Grayson, Rikiro Fukunaga, and Xiao-Ping Zhong. “Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.” J Immunol 190, no. 3 (February 1, 2013): 1026–37. https://doi.org/10.4049/jimmunol.1200026.
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  - Inoue, Makoto, and Mari L. Shinohara. “NLRP3 Inflammasome and MS/EAE.” Autoimmune Dis 2013 (2013): 859145. https://doi.org/10.1155/2013/859145.
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  - Lin, Yen-Yu, Mary E. Jones-Mason, Makoto Inoue, Anna Lasorella, Antonio Iavarone, Qi-Jing Li, Mari L. Shinohara, and Yuan Zhuang. “Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis.” J Immunol 189, no. 3 (August 1, 2012): 1400–1405. https://doi.org/10.4049/jimmunol.1200491.
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  - Inoue, Makoto, Kristi L. Williams, Michael D. Gunn, and Mari L. Shinohara. “NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis.” Proc Natl Acad Sci U S A 109, no. 26 (June 26, 2012): 10480–85. https://doi.org/10.1073/pnas.1201836109.
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  - Inoue, Makoto, Kristi L. Williams, Timothy Oliver, Peter Vandenabeele, Jayant V. Rajan, Edward A. Miao, and Mari L. Shinohara. “Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.” Sci Signal 5, no. 225 (May 22, 2012): ra38. https://doi.org/10.1126/scisignal.2002767.
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  - Huang, Xiaoyi, Fang Yuan, Meihua Liang, Hui-Wen Lo, Mari L. Shinohara, Cary Robertson, and Pei Zhong. “M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer.” Plos One 7, no. 7 (2012): e41632. https://doi.org/10.1371/journal.pone.0041632.
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  - Michalek, Ryan D., Valerie A. Gerriets, Amanda G. Nichols, Makoto Inoue, Dmitri Kazmin, Ching-Yi Chang, Mary A. Dwyer, et al. “Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.” Proc Natl Acad Sci U S A 108, no. 45 (November 8, 2011): 18348–53. https://doi.org/10.1073/pnas.1108856108.
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  - Inoue, Makoto, and Mari L. Shinohara. “Intracellular osteopontin (iOPN) and immunity.” Immunol Res 49, no. 1–3 (April 2011): 160–72. https://doi.org/10.1007/s12026-010-8179-5.
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  - Baliga, Sunanda S., Gary F. Merrill, Mari L. Shinohara, and David T. Denhardt. “Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen.” Plos One 6, no. 1 (January 21, 2011): e14568. https://doi.org/10.1371/journal.pone.0014568.
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  - Inoue, Makoto, Yasuhiro Moriwaki, Tomohiro Arikawa, Yu-Hsun Chen, Young Joo Oh, Timothy Oliver, and Mari L. Shinohara. “Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses.” J Immunol 186, no. 1 (January 1, 2011): 19–23. https://doi.org/10.4049/jimmunol.1002735.
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  - Alvarez Arias, Diana A., Nami McCarty, Linrong Lu, Roberto A. Maldonado, Mari L. Shinohara, and Harvey Cantor. “Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells.” Proc Natl Acad Sci U S A 107, no. 6 (February 9, 2010): 2556–61. https://doi.org/10.1073/pnas.0913671107.
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  - Egli, Dieter, Vladislav M. Sandler, Mari L. Shinohara, Harvey Cantor, and Kevin Eggan. “Reprogramming after chromosome transfer into mouse blastomeres.” Curr Biol 19, no. 16 (August 25, 2009): 1403–9. https://doi.org/10.1016/j.cub.2009.06.065.
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  - Cantor, Harvey, and Mari L. Shinohara. “Regulation of T-helper-cell lineage development by osteopontin: the inside story.” Nat Rev Immunol 9, no. 2 (February 2009): 137–41. https://doi.org/10.1038/nri2460.
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  - Shinohara, Mari L., June-Ho Kim, Virgilio A. Garcia, and Harvey Cantor. “Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.” Immunity 29, no. 1 (July 18, 2008): 68–78. https://doi.org/10.1016/j.immuni.2008.05.008.
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  - Shinohara, Mari L., Hye-Jung Kim, June-Ho Kim, Virgilio A. Garcia, and Harvey Cantor. “Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells.” Proc Natl Acad Sci U S A 105, no. 20 (May 20, 2008): 7235–39. https://doi.org/10.1073/pnas.0802301105.
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  - Shinohara, Mari L., and Harvey Cantor. “The bridge between dendritic cells and asthma.” Nat Med 13, no. 5 (May 2007): 536–38. https://doi.org/10.1038/nm0507-536.
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  - Shinohara, Mari L., Linrong Lu, Jing Bu, Miriam B. F. Werneck, Koichi S. Kobayashi, Laurie H. Glimcher, and Harvey Cantor. “Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.” Nat Immunol 7, no. 5 (May 2006): 498–506. https://doi.org/10.1038/ni1327.
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  - SHINOHARA, M. L. “Osteopontin expression is essential for interferon-α production by plasmacytoid dendritic cells.” Nat. Immunol. 7 (2006): 498–506.
  - Shinohara, Mari L., Marianne Jansson, Eun Sook Hwang, Miriam B. F. Werneck, Laurie H. Glimcher, and Harvey Cantor. “T-bet-dependent expression of osteopontin contributes to T cell polarization.” Proc Natl Acad Sci U S A 102, no. 47 (November 22, 2005): 17101–6. https://doi.org/10.1073/pnas.0508666102.
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  - Jacobs, Jonathan P., Allison R. Pettit, Mari L. Shinohara, Marianne Jansson, Harvey Cantor, Ellen M. Gravallese, Diane Mathis, and Christophe Benoist. “Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis.” Arthritis Rheum 50, no. 8 (August 2004): 2685–94. https://doi.org/10.1002/art.20381.
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  - McCarty, Nami, Mari L. Shinohara, Linrong Lu, and Harvey Cantor. “Detailed analysis of gene expression during development of T cell lineages in the thymus.” Proc Natl Acad Sci U S A 101, no. 25 (June 22, 2004): 9339–44. https://doi.org/10.1073/pnas.0402654101.
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  - Hu, Dan, Koichi Ikizawa, Linrong Lu, Marie E. Sanchirico, Mari L. Shinohara, and Harvey Cantor. “Analysis of regulatory CD8 T cells in Qa-1-deficient mice.” Nat Immunol 5, no. 5 (May 2004): 516–23. https://doi.org/10.1038/ni1063.
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  - Shinohara, Mari L., Alejandro Correa, Deborah Bell-Pedersen, Jay C. Dunlap, and Jennifer J. Loros. “Neurospora clock-controlled gene 9 (ccg-9) encodes trehalose synthase: circadian regulation of stress responses and development.” Eukaryot Cell 1, no. 1 (February 2002): 33–43. https://doi.org/10.1128/EC.1.1.33-43.2002.
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  - Shinohara, M. L., M. Ihara, M. Abo, M. Hashida, S. Takagi, and T. C. Beck. “A novel thermostable branching enzyme from an extremely thermophilic bacterial species, Rhodothermus obamensis.” Appl Microbiol Biotechnol 57, no. 5–6 (December 2001): 653–59. https://doi.org/10.1007/s00253-001-0841-3.
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  - Kessler, B. M., A. M. Lennon-Duménil, M. L. Shinohara, M. A. Lipes, and H. L. Ploegh. “LMP2 expression and proteasome activity in NOD mice.” Nat Med 6, no. 10 (October 2000): 1064. https://doi.org/10.1038/80346.
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  - Runnels, H. A., W. A. Watkins, and J. J. Monaco. “LMP2 expression and proteasome activity in NOD mice.” Nat Med 6, no. 10 (October 2000): 1064–65. https://doi.org/10.1038/80349.
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  - Shinohara, M. L., K. F. LoBuglio, and S. O. Rogers. “Comparison of ribosomal DNA ITS regions among geographic isolates of Cenococcum geophilum.” Curr Genet 35, no. 5 (June 1999): 527–35. https://doi.org/10.1007/s002940050449.
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  - Shinohara, M. L., J. J. Loros, and J. C. Dunlap. “Glyceraldehyde-3-phosphate dehydrogenase is regulated on a daily basis by the circadian clock.” J Biol Chem 273, no. 1 (January 2, 1998): 446–52. https://doi.org/10.1074/jbc.273.1.446.
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  - Bell-Pedersen, D., M. L. Shinohara, J. J. Loros, and J. C. Dunlap. “Circadian clock-controlled genes isolated from Neurospora crassa are late night- to early morning-specific.” Proc Natl Acad Sci U S A 93, no. 23 (November 12, 1996): 13096–101. https://doi.org/10.1073/pnas.93.23.13096.
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  - Shinohara, M. L., K. F. LoBuglio, and S. O. Rogers. “Group-I intron family in the nuclear ribosomal RNA small subunit genes of Cenococcum geophilum isolates.” Curr Genet 29, no. 4 (March 1996): 377–87. https://doi.org/10.1007/BF02208619.
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  - Dunlap, J. C., J. J. Loros, M. Merrow, S. Crosthwaite, D. Bell-Pedersen, N. Garceau, M. Shinohara, H. Cho, and C. Luo. “The genetic and molecular dissection of a prototypic circadian system.” Prog Brain Res 111 (1996): 11–27. https://doi.org/10.1016/s0079-6123(08)60397-0.
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  - Rogers, S. O., Z. H. Yan, M. Shinohara, K. F. LoBuglio, and C. J. Wang. “Messenger RNA intron in the nuclear 18s ribosomal RNA gene of deuteromycetes.” Curr Genet 23, no. 4 (1993): 338–42. https://doi.org/10.1007/BF00310896.
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- Other Articles
  - Klionsky, Daniel J., Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).” Autophagy, 2016. https://doi.org/10.1080/15548627.2015.1100356.
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- Conference Papers
  - Ratiu, Jeremy J., William Barclay, Qun Wang, Mari L. Shinohara, and Yuan Zhuang. “Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection pre-T cells.” In The Journal of Immunology, 208:107.18-107.18. The American Association of Immunologists, 2022. https://doi.org/10.4049/jimmunol.208.supp.107.18.
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  - Gregory, S. G., S. Arvai, G. D. Dalton, K. Pegram, M. Kanayama, A. S. Chao, G. K. Matsushima, M. L. Shinohara, and E. J. Benner. “Characterizing the immunomodulation and remyelination efficacy of 20-aHydroxycholesterol in pre-clinical models of multiple sclerosis.” In Multiple Sclerosis Journal, 28:247–247, 2022.
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  - Deerhake, M Elizabeth, Keiko Danzaki, Makoto Inoue, Emre Cardakli, Toshiaki Nonaka, Nupur Aggarwal, Will Barclay, Ru-Rong Ji, and Mari L. Shinohara. “Dectin-1 limits CNS autoimmunity through a non-canonical pathway.” In Journal of Immunology, Vol. 206, 2021.
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  - Deerhake, M Elizabeth, Keiko Danzaki, Makoto Inoue, Emre D. Cardakli, Toshiaki Nonaka, Nupur Aggarwal, William E. Barclay, Ru Rong Ji, and Mari L. Shinohara. “Dectin-1 limits central nervous system autoimmunity through a non-canonical pathway,” 2020. https://doi.org/10.1101/2020.05.06.080481.
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  - Kanayama, Masashi, Shengjie Xu, Keiko Danzaki, Jason R. Gibson, Makoto Inoue, Simon G. Gregory, and Mari L. Shinohara. “Skewing the population balance between lymphoid and myeloid cells by osteopontin isoforms.” In Cytokine, 100:161–161. ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2017.
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  - Shinohara, M. L., and H. Cantor. “Innate immune mechanisms that promote development of effector and regulatory CD4 lineages in EAE (Experimental Autoimmune Encephalomyelitis).” In Journal of Neuroimmunology, 178:34–34, 2006.
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- Preprints
  - Ratiu, Jeremy, William Barclay, Qun Wang, Sebastian Wellford, Naren Mehta, Melissa Harnois, Devon DiPalma, et al. “Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection pre-T cells.” Research Square, 2022. https://doi.org/10.21203/rs.3.rs-1226201/v1.
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Teaching & Mentoring
Recent Courses
- IMMUNOL 731S: Immunology Seminar 2023
- IMMUNOL 732S: Immunology Seminar 2023
- IMMUNOL 791A: Research in Immunology 2023
- IMMUNOL 791B: Research in Immunology 2023
- IMMUNOL 731S: Immunology Seminar 2022
- IMMUNOL 732S: Immunology Seminar 2022
- IMMUNOL 791A: Research in Immunology 2022
- IMMUNOL 791B: Research in Immunology 2022
- IMMUNOL 731S: Immunology Seminar 2021
- IMMUNOL 732S: Immunology Seminar 2021
- IMMUNOL 791A: Research in Immunology 2021
- IMMUNOL 791B: Research in Immunology 2021
Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship
- Summer Neuroscience Program Mentor. Summer Neuroscience Program. 2019 2019
Service to the Profession
- Participant. Faculty Short Course on Improving Departmental Climate. Duke Office of Faculty Advancement & Duke Office of Institutional Equity. August 2, 2021 - August 5, 2021 2021
Service to Duke
- Duke University. Executive Committee of Academic Council. 2016 - 2018 2016 - 2018

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Leadership & Clinical Positions at Duke

Subject Headings

External Relationships

Selected Publications

Academic Articles

Other Articles

Conference Papers

Preprints

Recent Courses

Outreach & Engaged Scholarship

Service to the Profession

Service to Duke