Neonatal testosterone and handedness in yearling rhesus monkeys (Macaca mulatta).

Published

Journal Article

This study investigated the relationship between neonatal testosterone (T) and hand bias in young rhesus monkeys (Macaca mulatta). Subjects (n = 8 per group) included: neonatally androgen-suppressed males, using a Nal-Lys gonadotropin releasing hormone (GnRH) antagonist (Antide); androgen-suppressed males receiving T replacement by a long-acting T preparation (CDB); control males; and control females. Antide suppressed T to the female range, whereas CDB replacement produced supranormal levels. Visually guided reaching, in a social context, showed a population-level left-hand bias. Males with elevated T did not show a stronger left-hand bias than males with normal T, but did show a stronger bias for the preferred hand whether left or right. Males with Antide-suppressed T showed an intermediate degree of hand bias. Results suggest that high neonatal T levels affect laterality and raise the possibility that GnRH analogues influence brain development. These data suggest a broad influence of the CNS-pituitary-testicular axis on brain asymmetries and provide support for an early neonatal period of T-influenced brain differentiation.

Full Text

Duke Authors

Cited Authors

  • Drea, CM; Wallen, K; Akinbami, MA; Mann, DR

Published Date

  • December 1995

Published In

Volume / Issue

  • 58 / 6

Start / End Page

  • 1257 - 1262

PubMed ID

  • 8623029

Pubmed Central ID

  • 8623029

Electronic International Standard Serial Number (EISSN)

  • 1873-507X

International Standard Serial Number (ISSN)

  • 0031-9384

Digital Object Identifier (DOI)

  • 10.1016/0031-9384(95)02026-8

Language

  • eng