Common genetic variation and the control of HIV-1 in humans.

Published

Journal Article

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.

Full Text

Duke Authors

Cited Authors

  • Fellay, J; Ge, D; Shianna, KV; Colombo, S; Ledergerber, B; Cirulli, ET; Urban, TJ; Zhang, K; Gumbs, CE; Smith, JP; Castagna, A; Cozzi-Lepri, A; De Luca, A; Easterbrook, P; Günthard, HF; Mallal, S; Mussini, C; Dalmau, J; Martinez-Picado, J; Miro, JM; Obel, N; Wolinsky, SM; Martinson, JJ; Detels, R; Margolick, JB; Jacobson, LP; Descombes, P; Antonarakis, SE; Beckmann, JS; O'Brien, SJ; Letvin, NL; McMichael, AJ; Haynes, BF; Carrington, M; Feng, S; Telenti, A; Goldstein, DB; NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI),

Published Date

  • December 24, 2009

Published In

Volume / Issue

  • 5 / 12

Start / End Page

  • e1000791 -

PubMed ID

  • 20041166

Pubmed Central ID

  • 20041166

Electronic International Standard Serial Number (EISSN)

  • 1553-7404

International Standard Serial Number (ISSN)

  • 1553-7390

Digital Object Identifier (DOI)

  • 10.1371/journal.pgen.1000791

Language

  • eng