Immune reconstitution in patients with HIV infection.


Journal Article (Review)

The peripheral T cell pool is damaged by HIV-1 infection and can be regenerated by production of new T lymphocytes either from the thymus or from proliferation of post-thymic T cells. A critical question for AIDS patients is whether treatment with antiretroviral drugs can restore the capability to produce new T lymphocytes. The development of a new assay of thymus function in adults (the measurement of T cell receptor excision circles, TRECs), and studies of thymus biopsies in untreated and treated HIV-1-infected patients, have suggested that in select patients the thymus can regenerate on antiretroviral therapy. New strategies to overcome the thymic atrophy of aging are needed to improve thymic function in the majority of AIDS patients.

Full Text

Duke Authors

Cited Authors

  • Sempowski, GD; Haynes, BF

Published Date

  • 2002

Published In

Volume / Issue

  • 53 /

Start / End Page

  • 269 - 284

PubMed ID

  • 11818474

Pubmed Central ID

  • 11818474

International Standard Serial Number (ISSN)

  • 0066-4219

Digital Object Identifier (DOI)

  • 10.1146/


  • eng

Conference Location

  • United States