Immune reconstitution in patients with HIV infection.
Published
Journal Article (Review)
The peripheral T cell pool is damaged by HIV-1 infection and can be regenerated by production of new T lymphocytes either from the thymus or from proliferation of post-thymic T cells. A critical question for AIDS patients is whether treatment with antiretroviral drugs can restore the capability to produce new T lymphocytes. The development of a new assay of thymus function in adults (the measurement of T cell receptor excision circles, TRECs), and studies of thymus biopsies in untreated and treated HIV-1-infected patients, have suggested that in select patients the thymus can regenerate on antiretroviral therapy. New strategies to overcome the thymic atrophy of aging are needed to improve thymic function in the majority of AIDS patients.
Full Text
Duke Authors
Cited Authors
- Sempowski, GD; Haynes, BF
Published Date
- 2002
Published In
Volume / Issue
- 53 /
Start / End Page
- 269 - 284
PubMed ID
- 11818474
Pubmed Central ID
- 11818474
International Standard Serial Number (ISSN)
- 0066-4219
Digital Object Identifier (DOI)
- 10.1146/annurev.med.53.082901.104032
Language
- eng
Conference Location
- United States