Wide variation in the multiplicity of HIV-1 infection among injection drug users.

Journal Article (Journal Article)

Recent studies indicate that sexual transmission of human immunodeficiency virus type 1 (HIV-1) generally results from productive infection by only one virus, a finding attributable to the mucosal barrier. Surprisingly, a recent study of injection drug users (IDUs) from St. Petersburg, Russia, also found most subjects to be acutely infected by a single virus. Here, we show by single-genome amplification and sequencing in a different IDU cohort that 60% of IDU subjects were infected by more than one virus, including one subject who was acutely infected by at least 16 viruses. Multivariant transmission was more common in IDUs than in heterosexuals (60% versus 19%; odds ratio, 6.14; 95% confidence interval [CI], 1.37 to 31.27; P = 0.008). These findings highlight the diversity in HIV-1 infection risks among different IDU cohorts and the challenges faced by vaccines in protecting against this mode of infection.

Full Text

Duke Authors

Cited Authors

  • Bar, KJ; Li, H; Chamberland, A; Tremblay, C; Routy, JP; Grayson, T; Sun, C; Wang, S; Learn, GH; Morgan, CJ; Schumacher, JE; Haynes, BF; Keele, BF; Hahn, BH; Shaw, GM

Published Date

  • June 2010

Published In

Volume / Issue

  • 84 / 12

Start / End Page

  • 6241 - 6247

PubMed ID

  • 20375173

Pubmed Central ID

  • PMC2876625

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

Digital Object Identifier (DOI)

  • 10.1128/JVI.00077-10


  • eng

Conference Location

  • United States