The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression.
Journal Article (Letter)
Ma’am – We read with great interest the article by He et al. [2008] describing the effects on HIV acquisition and disease progression of a single-nucleotide polymorphism (SNP, rs2814778, -46T→C) that disrupts the promoter region of the Duffy antigen receptor for chemokines (DARC) gene and abolishes gene expression in red blood cells. He et al. reported that HIV-infected African Americans have a frequency of the null homozygous genotype (-46C/C) of 70% while non-HIV infected individuals have a null genotype frequency of 60%. Based on this frequency difference they argued that the null allele confers susceptibility to infection with HIV-1. They also reported that the null genotype is associated with better outcomes amongst those who do become infected, including longer survival, slower loss of CD4+ T-lymphocytes, and delayed progression to HIV-associated dementia.
Full Text
Duke Authors
Cited Authors
- Walley, NM; Julg, B; Dickson, SP; Fellay, J; Ge, D; Walker, BD; Carrington, M; Cohen, MS; de Bakker, PIW; Goldstein, DB; Shianna, KV; Haynes, BF; Letvin, NL; McMichael, AJ; Michael, NL; Weintrob, AC
Published Date
- May 8, 2009
Published In
Volume / Issue
- 5 / 5
Start / End Page
- 408 - 410
PubMed ID
- 19454339
Pubmed Central ID
- PMC2720554
Electronic International Standard Serial Number (EISSN)
- 1934-6069
Digital Object Identifier (DOI)
- 10.1016/j.chom.2009.04.011
Language
- eng
Conference Location
- United States