Skip to main content
Journal cover image

The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression.

Publication ,  Journal Article
Walley, NM; Julg, B; Dickson, SP; Fellay, J; Ge, D; Walker, BD; Carrington, M; Cohen, MS; de Bakker, PIW; Goldstein, DB; Shianna, KV ...
Published in: Cell Host Microbe
May 8, 2009

Ma’am – We read with great interest the article by He et al. [2008] describing the effects on HIV acquisition and disease progression of a single-nucleotide polymorphism (SNP, rs2814778, -46T→C) that disrupts the promoter region of the Duffy antigen receptor for chemokines (DARC) gene and abolishes gene expression in red blood cells. He et al. reported that HIV-infected African Americans have a frequency of the null homozygous genotype (-46C/C) of 70% while non-HIV infected individuals have a null genotype frequency of 60%. Based on this frequency difference they argued that the null allele confers susceptibility to infection with HIV-1. They also reported that the null genotype is associated with better outcomes amongst those who do become infected, including longer survival, slower loss of CD4+ T-lymphocytes, and delayed progression to HIV-associated dementia.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

May 8, 2009

Volume

5

Issue

5

Start / End Page

408 / 410

Location

United States

Related Subject Headings

  • White People
  • Receptors, Cell Surface
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • Duffy Blood-Group System
  • Disease Progression
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Walley, N. M., Julg, B., Dickson, S. P., Fellay, J., Ge, D., Walker, B. D., … Weintrob, A. C. (2009). The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression. Cell Host Microbe, 5(5), 408–410. https://doi.org/10.1016/j.chom.2009.04.011
Walley, Nicole M., Boris Julg, Samuel P. Dickson, Jacques Fellay, Dongliang Ge, Bruce D. Walker, Mary Carrington, et al. “The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression.Cell Host Microbe 5, no. 5 (May 8, 2009): 408–10. https://doi.org/10.1016/j.chom.2009.04.011.
Walley NM, Julg B, Dickson SP, Fellay J, Ge D, Walker BD, et al. The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression. Cell Host Microbe. 2009 May 8;5(5):408–10.
Walley, Nicole M., et al. “The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression.Cell Host Microbe, vol. 5, no. 5, May 2009, pp. 408–10. Pubmed, doi:10.1016/j.chom.2009.04.011.
Walley NM, Julg B, Dickson SP, Fellay J, Ge D, Walker BD, Carrington M, Cohen MS, de Bakker PIW, Goldstein DB, Shianna KV, Haynes BF, Letvin NL, McMichael AJ, Michael NL, Weintrob AC. The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression. Cell Host Microbe. 2009 May 8;5(5):408–410.
Journal cover image

Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

May 8, 2009

Volume

5

Issue

5

Start / End Page

408 / 410

Location

United States

Related Subject Headings

  • White People
  • Receptors, Cell Surface
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • Duffy Blood-Group System
  • Disease Progression