The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression.

Journal Article (Letter)

Ma’am – We read with great interest the article by He et al. [2008] describing the effects on HIV acquisition and disease progression of a single-nucleotide polymorphism (SNP, rs2814778, -46T→C) that disrupts the promoter region of the Duffy antigen receptor for chemokines (DARC) gene and abolishes gene expression in red blood cells. He et al. reported that HIV-infected African Americans have a frequency of the null homozygous genotype (-46C/C) of 70% while non-HIV infected individuals have a null genotype frequency of 60%. Based on this frequency difference they argued that the null allele confers susceptibility to infection with HIV-1. They also reported that the null genotype is associated with better outcomes amongst those who do become infected, including longer survival, slower loss of CD4+ T-lymphocytes, and delayed progression to HIV-associated dementia.

Full Text

Duke Authors

Cited Authors

  • Walley, NM; Julg, B; Dickson, SP; Fellay, J; Ge, D; Walker, BD; Carrington, M; Cohen, MS; de Bakker, PIW; Goldstein, DB; Shianna, KV; Haynes, BF; Letvin, NL; McMichael, AJ; Michael, NL; Weintrob, AC

Published Date

  • May 8, 2009

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 408 - 410

PubMed ID

  • 19454339

Pubmed Central ID

  • PMC2720554

Electronic International Standard Serial Number (EISSN)

  • 1934-6069

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2009.04.011

Language

  • eng

Conference Location

  • United States