Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals.

Published

Journal Article

HIV-1-specific T lymphocyte responses in individuals exposed to HIV-1 but who remain persistently seronegative (HESNs) have been reported in some but not all previous studies. This study was designed to resolve unequivocally the question of whether HESNs make HIV-1-specific T cell responses. We performed a blind investigation to measure HIV-1-specific T cell responses in both HIV-1-serodiscordant couples and HIV-1-unexposed seronegative controls (HUSNs). We found low-frequency HIV-1-specific T cells in both HESNs and HUSNs but show that the response rates were higher over time in the former (P = 0.01). Furthermore, the magnitudes of the HIV-1-specific T cell responses were significantly higher among responding HESNs than among HUSNs over time (P = 0.002). In both groups, responses were mediated by CD4 T cells. The responses were mapped to single peptides, which often corresponded to epitopes restricted by multiple HLA-DR types that have previously been detected in HIV-1-infected patients. HIV-1-specific T cell responses in HUSNs and some HESNs likely represent cross-reactivity to self or foreign non-HIV-1 antigens. The significantly greater T cell responses in HESNs, including in two who were homozygous for CCR5Δ32, demonstrates that HIV-1-specific T cell responses can be induced or augmented by exposure to HIV-1 without infection.

Full Text

Duke Authors

Cited Authors

  • Ritchie, AJ; Campion, SL; Kopycinski, J; Moodie, Z; Wang, ZM; Pandya, K; Moore, S; Liu, MKP; Brackenridge, S; Kuldanek, K; Legg, K; Cohen, MS; Delwart, EL; Haynes, BF; Fidler, S; McMichael, AJ; Goonetilleke, N

Published Date

  • April 2011

Published In

Volume / Issue

  • 85 / 7

Start / End Page

  • 3507 - 3516

PubMed ID

  • 21270166

Pubmed Central ID

  • 21270166

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

Digital Object Identifier (DOI)

  • 10.1128/JVI.02444-10

Language

  • eng

Conference Location

  • United States