Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria.


Journal Article

Tafazzin is a conserved mitochondrial protein that is required to maintain normal content and composition of cardiolipin. We used electron tomography to investigate the effect of tafazzin deletion on mitochondrial structure and found that cellular differentiation plays a crucial role in the manifestation of abnormalities. This conclusion was reached by comparing differentiated cardiomyocytes with embryonic stem cells from mouse and by comparing different tissues from Drosophila melanogaster. The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation.

Full Text

Duke Authors

Cited Authors

  • Acehan, D; Khuchua, Z; Houtkooper, RH; Malhotra, A; Kaufman, J; Vaz, FM; Ren, M; Rockman, HA; Stokes, DL; Schlame, M

Published Date

  • April 2009

Published In

Volume / Issue

  • 9 / 2

Start / End Page

  • 86 - 95

PubMed ID

  • 19114128

Pubmed Central ID

  • 19114128

Electronic International Standard Serial Number (EISSN)

  • 1872-8278

Digital Object Identifier (DOI)

  • 10.1016/j.mito.2008.12.001


  • eng

Conference Location

  • Netherlands