Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria.
Publication
, Journal Article
Acehan, D; Khuchua, Z; Houtkooper, RH; Malhotra, A; Kaufman, J; Vaz, FM; Ren, M; Rockman, HA; Stokes, DL; Schlame, M
Published in: Mitochondrion
April 2009
Tafazzin is a conserved mitochondrial protein that is required to maintain normal content and composition of cardiolipin. We used electron tomography to investigate the effect of tafazzin deletion on mitochondrial structure and found that cellular differentiation plays a crucial role in the manifestation of abnormalities. This conclusion was reached by comparing differentiated cardiomyocytes with embryonic stem cells from mouse and by comparing different tissues from Drosophila melanogaster. The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation.
Duke Scholars
Published In
Mitochondrion
DOI
EISSN
1872-8278
Publication Date
April 2009
Volume
9
Issue
2
Start / End Page
86 / 95
Location
Netherlands
Related Subject Headings
- Transcription Factors
- Mitochondrial Membranes
- Mitochondria
- Mice
- Gene Deletion
- Electron Microscope Tomography
- Drosophila melanogaster
- Drosophila Proteins
- Cardiolipins
- Biochemistry & Molecular Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Acehan, D., Khuchua, Z., Houtkooper, R. H., Malhotra, A., Kaufman, J., Vaz, F. M., … Schlame, M. (2009). Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. Mitochondrion, 9(2), 86–95. https://doi.org/10.1016/j.mito.2008.12.001
Acehan, Devrim, Zaza Khuchua, Riekelt H. Houtkooper, Ashim Malhotra, Johanna Kaufman, Frédéric M. Vaz, Mindong Ren, Howard A. Rockman, David L. Stokes, and Michael Schlame. “Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria.” Mitochondrion 9, no. 2 (April 2009): 86–95. https://doi.org/10.1016/j.mito.2008.12.001.
Acehan D, Khuchua Z, Houtkooper RH, Malhotra A, Kaufman J, Vaz FM, et al. Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. Mitochondrion. 2009 Apr;9(2):86–95.
Acehan, Devrim, et al. “Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria.” Mitochondrion, vol. 9, no. 2, Apr. 2009, pp. 86–95. Pubmed, doi:10.1016/j.mito.2008.12.001.
Acehan D, Khuchua Z, Houtkooper RH, Malhotra A, Kaufman J, Vaz FM, Ren M, Rockman HA, Stokes DL, Schlame M. Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. Mitochondrion. 2009 Apr;9(2):86–95.
Published In
Mitochondrion
DOI
EISSN
1872-8278
Publication Date
April 2009
Volume
9
Issue
2
Start / End Page
86 / 95
Location
Netherlands
Related Subject Headings
- Transcription Factors
- Mitochondrial Membranes
- Mitochondria
- Mice
- Gene Deletion
- Electron Microscope Tomography
- Drosophila melanogaster
- Drosophila Proteins
- Cardiolipins
- Biochemistry & Molecular Biology