Howard Allan Rockman
Edward S. Orgain Distinguished Professor of Cardiology, in the School of Medicine
Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure
Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or genes ablated followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.
Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.
2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.
Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or genes ablated followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.
Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.
2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.
Current Appointments & Affiliations
- Edward S. Orgain Distinguished Professor of Cardiology, in the School of Medicine, Medicine, Cardiology, Medicine 2008
- Professor of Medicine, Medicine, Cardiology, Medicine 2002
- Professor in Cell Biology, Cell Biology, Basic Science Departments 2011
Contact Information
- 226 Clin Res Lab Bldg, Duke Box 102151, Durham, NC 27710
- Duke Box 102151, Durham, NC 27710
-
h.rockman@duke.edu
(919) 668-2520
- Background
-
Education, Training, & Certifications
- Cardiology Fellow, Medicine, University of California, San Diego 1987 - 1991
- Medical Resident, Medicine, Montreal General Hospital (Canada) 1984 - 1987
- M.D., McGill University (Canada) 1983
-
Previous Appointments & Affiliations
- Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2002 - 2020
- Assistant Research Professor in Cell Biology, Cell Biology, Basic Science Departments 2000 - 2010
- Chief, Division of Cardiology, Medicine, Cardiology, Medicine 2007 - 2010
- Vice-chair for Basic Research in the Department of Medicine, Medicine, Clinical Science Departments 2007 - 2009
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 1999 - 2002
- Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 1999
-
Leadership & Clinical Positions at Duke
- Director, Duke Cardiovascular Research Center
- Recognition
-
Awards & Honors
- Distinguished Faculty Award. Duke University Alumni Association. 2016
- Distinguished Scientist Award. American Heart Association. 2015
- Distinguished Achievement Award. American Heart Association. 2011
- Master Clinician/Teacher Award. School of Medicine, Duke University.. 2009
- Elected Member. Association of American Physicians.. 2006
- Elected Member. American Society for Clinical Investigation. 1999
- Clinical Scientist Awards in Translational Research. Burroughs Wellcome Fund. 1998
- Research
-
Selected Grants
- Stimulating Access to Research in Residency (StARR) - NHLBI awarded by National Institutes of Health 2018 - 2028
- Building Interdisciplinary Research Careers in Women's Health awarded by National Institutes of Health 2002 - 2027
- Myovascular Mechanisms of Cardiac Growth and Regeneration awarded by National Institutes of Health 2022 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Improving Cardiac Transplant Outcomes Through PD-L1 Overexpression Gene Therapy 2023 - 2025
- Regulation of myocardial GPCRs by USP20 in normal and hypertrophied heart awarded by National Institutes of Health 2021 - 2025
- Improving Cardiac Transplant Outcomes Through PD-L1 Overexpression Gene Therapy awarded by American Heart Association 2023 - 2024
- National Research Service Award (F31) awarded by National Institutes of Health 2021 - 2024
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2024
- Targeting Wnt-signaling to prevent sudden death in pediatric arrhythmic cardiomyopathyTBD 2020 - 2023
- Mandel 2021-2024 2018 - 2023
- Mechanisms of Maladaptation in Heart Failure awarded by National Institutes of Health 1996 - 2023
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2023
- Integrated Cellular and Tissue Engineering for Ischemic Heart Disease awarded by University of Alabama at Birmingham 2016 - 2023
- Establishing Wnt signaling-mediated pro-arrhythmic cardiac remodeling awarded by American Heart Association 2021 - 2023
- The Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Myocardial Fuel Section awarded by National Institutes of Health 2018 - 2023
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2023
- Copper Homeostasis in Mammals awarded by National Institutes of Health 2004 - 2023
- The Role of Junctophilin Type 2 in Cardiac Node Automaticity awarded by National Institutes of Health 2018 - 2022
- Probing the Role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by University of Pennsylvania 2017 - 2021
- Mechanistic studies of Mas receptor activation and its role in aortic aneurysm formation awarded by National Institutes of Health 2017 - 2021
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2021
- Determining the role of PRDM16 in rapidly progressive pediatric cardiomyopathy 2019 - 2021
- Novel Mechanisms and Therapies in Heart Failure awarded by National Institutes of Health 2004 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- TREK-1 in fibroblast differentiation and cardiac fibrosis development awarded by National Institutes of Health 2015 - 2020
- Paracrine Control of Blood Pressure by Renal Intercalated Cells awarded by National Institutes of Health 2015 - 2020
- Bioengineering a Living Tissue Conductor awarded by National Institutes of Health 2015 - 2018
- Noncanonical Receptor Signaling in Pulmonary Arterial Hypertension awarded by National Institutes of Health 2013 - 2018
- The Role of SIRT5 in Regulating Cardiac Function and Metabolism awarded by National Institutes of Health 2015 - 2018
- Probing the role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart 2017
- Carvedilol Stimulated Gi-beta-Arrestin Biased Beta1-Adrenergic Receptor Signaling awarded by American Heart Association 2014 - 2016
- Molecular Mechanisms of Thoracic Aortic Aneurysms 2014 - 2016
- Function and Integration of Stem Cell-derived Cardiac Tissue Patch awarded by National Institutes of Health 2010 - 2016
- Iron homeostasis in mammalian muscle awarded by National Institutes of Health 2011 - 2016
- Role of GRK6-Mediated Oxytocin Receptor Desensitization in Labor awarded by National Institutes of Health 2012 - 2016
- Identifying Cardiomyopathy Genes in Mice and Drosophila awarded by National Institutes of Health 2006 - 2015
- Prostaglandin E2 and Regulation of Kidney Function awarded by National Institutes of Health 2005 - 2015
- TREK-1 in fibroblast differentiation and cardiac fibrosis development awarded by American Heart Association 2014 - 2015
- Institutional Training Grant in Pediatric Cardiology awarded by National Institutes of Health 2009 - 2015
- Novel pathways modulating Raf-mediated cardiac hypertrophy awarded by National Institutes of Health 2013 - 2015
- The role of STIM1 in cardiac and skeletal muscle function awarded by National Institutes of Health 2009 - 2014
- Agilent Direct Drive 9.4T MRS/MRI Console awarded by National Institutes of Health 2012 - 2013
- Genetic modifiers of dilated cardiomyopathy in adult Drosophila awarded by National Institutes of Health 2007 - 2012
- B-Arrestins and G Protein-Coupled Receptor Kinases in Cardiovascular Function awarded by National Institutes of Health 2002 - 2012
- Candidate Genes and Longitudinal Disability Phenotypes awarded by National Institutes of Health 2006 - 2012
- Small Animal PET / CT Molecular Imaging awarded by National Institutes of Health 2011 - 2012
- Role of Homer Proteins in Calcium Signaling in Muscle awarded by National Institutes of Health 2005 - 2011
- Multispectral Imaging Flow Cytometer Core awarded by National Institutes of Health 2010 - 2011
- Identification of genetics modifiers of heart disease awarded by National Institutes of Health 2007 - 2011
- Cardiac Effects of a Mitochondrial Progesterone Receptor awarded by National Institutes of Health 2008 - 2010
- Regulation of Cardiac Adrenergic Function by S-nitrosylation awarded by National Institutes of Health 2009
- Genes That Regulate Progression of Kidney Disease and Its Cardiovascular Effects awarded by National Institutes of Health 2007 - 2009
- Skeletal Muscle Plasticity Following LVAD Support awarded by National Institutes of Health 2006 - 2009
- Myocardial Gene Transfer during Cardiac Surgery in Swine awarded by National Institutes of Health 2003 - 2008
- Role of Sfrp2 in Cardiac Regeneration awarded by National Institutes of Health 2006 - 2007
- Modifier Genes in Heart Failure awarded by National Institutes of Health 2001 - 2007
- Distance Learning Models for Clinical Research Training awarded by National Institutes of Health 1999 - 2006
- Genes that Regulate Target Organ Damage in Hypertension awarded by National Institutes of Health 2001 - 2006
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1998 - 2006
- Protecting the Ischemic Heart awarded by National Institutes of Health 2003 - 2005
- Regulation of BAR Function by Localized PI3K Inhibition awarded by National Institutes of Health 1999 - 2004
- Phenotypic Screens for Cardiovascular Mutations in Mice awarded by National Institutes of Health 2000 - 2004
- Beta adrenergic receptor phosphorylation - heart failure awarded by National Institutes of Health 1999 - 2003
- same awarded by National Institutes of Health 1999 - 2003
- same awarded by National Institutes of Health 1996 - 2001
-
External Relationships
- Living Proof Clinic
- Trevena, Inc.
- Publications & Artistic Works
-
Selected Publications
-
Academic Articles
-
Grogan, Alyssa, Emilio Y. Lucero, Haoran Jiang, and Howard A. Rockman. “Pathophysiology and pharmacology of G protein-coupled receptors in the heart.” Cardiovasc Res 119, no. 5 (May 22, 2023): 1117–29. https://doi.org/10.1093/cvr/cvac171.Full Text Link to Item
-
Jiang, Haoran, Daniella Galtes, Jialu Wang, and Howard A. Rockman. “G protein-coupled receptor signaling: transducers and effectors.” Am J Physiol Cell Physiol 323, no. 3 (September 1, 2022): C731–48. https://doi.org/10.1152/ajpcell.00210.2022.Full Text Link to Item
-
Bishawi, Muath, Franklin H. Lee, Dennis M. Abraham, Carolyn Glass, Stephanie J. Blocker, Daniel J. Cox, Zachary D. Brown, et al. “Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.” Iscience 25, no. 4 (April 15, 2022): 104086. https://doi.org/10.1016/j.isci.2022.104086.Full Text Link to Item
-
Wang, Jialu, Biswaranjan Pani, Ilhan Gokhan, Xinyu Xiong, Alem W. Kahsai, Haoran Jiang, Seungkirl Ahn, Robert J. Lefkowitz, and Howard A. Rockman. “β-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection.” Mol Pharmacol 100, no. 6 (December 2021): 568–79. https://doi.org/10.1124/molpharm.121.000359.Full Text Link to Item
-
Pfeiffer, Conrad T., Jialu Wang, Joao A. Paulo, Xue Jiang, Steven P. Gygi, and Howard A. Rockman. “Mapping Angiotensin II Type 1 Receptor-Biased Signaling Using Proximity Labeling and Proteomics Identifies Diverse Actions of Biased Agonists.” J Proteome Res 20, no. 6 (June 4, 2021): 3256–67. https://doi.org/10.1021/acs.jproteome.1c00080.Full Text Open Access Copy Link to Item
-
McMahon, Conor, Dean P. Staus, Laura M. Wingler, Jialu Wang, Meredith A. Skiba, Matthias Elgeti, Wayne L. Hubbell, Howard A. Rockman, Andrew C. Kruse, and Robert J. Lefkowitz. “Synthetic nanobodies as angiotensin receptor blockers.” Proc Natl Acad Sci U S A 117, no. 33 (August 18, 2020): 20284–91. https://doi.org/10.1073/pnas.2009029117.Full Text Link to Item
-
Manglik, Aashish, Laura M. Wingler, Howard A. Rockman, and Robert J. Lefkowitz. “β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19.” Circulation 142, no. 4 (July 28, 2020): 318–20. https://doi.org/10.1161/CIRCULATIONAHA.120.048723.Full Text Link to Item
-
Kim, Jihee, Chad A. Grotegut, James W. Wisler, Lan Mao, Paul B. Rosenberg, Howard A. Rockman, and Robert J. Lefkowitz. “The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility.” Proc Natl Acad Sci U S A 117, no. 22 (June 2, 2020): 12435–43. https://doi.org/10.1073/pnas.1920310117.Full Text Link to Item
-
Nielsen, Natalie R., Krsna V. Rangarajan, Lan Mao, Howard A. Rockman, and Kathleen M. Caron. “A murine model of increased coronary sinus pressure induces myocardial edema with cardiac lymphatic dilation and fibrosis.” Am J Physiol Heart Circ Physiol 318, no. 4 (April 1, 2020): H895–907. https://doi.org/10.1152/ajpheart.00436.2019.Full Text Link to Item
-
Rockman, Howard A. “Come sail away.” Jci Insight 4, no. 15 (August 8, 2019). https://doi.org/10.1172/jci.insight.131371.Full Text Link to Item
-
Yu, Samuel Mon-Wei, Pierre-Yves Jean-Charles, Dennis M. Abraham, Suneet Kaur, Clarice Gareri, Lan Mao, Howard A. Rockman, and Sudha K. Shenoy. “The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling.” J Biol Chem 294, no. 7 (February 15, 2019): 2500–2518. https://doi.org/10.1074/jbc.RA118.004926.Full Text Link to Item
-
Kim, Jihee, Chad A. Grotegut, James W. Wisler, Tianyu Li, Lan Mao, Minyong Chen, Wei Chen, Paul B. Rosenberg, Howard A. Rockman, and Robert J. Lefkowitz. “β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.” Skelet Muscle 8, no. 1 (December 27, 2018): 39. https://doi.org/10.1186/s13395-018-0184-8.Full Text Open Access Copy Link to Item
-
Abraham, Dennis M., Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Hong-Gang Wang, Stephan Frangakis, et al. “The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.” J Clin Invest 128, no. 11 (November 1, 2018): 4843–55. https://doi.org/10.1172/JCI95945.Full Text Link to Item
-
Luttrell, Louis M., Jialu Wang, Bianca Plouffe, Jeffrey S. Smith, Lama Yamani, Suneet Kaur, Pierre-Yves Jean-Charles, et al. “Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.” Sci Signal 11, no. 549 (September 25, 2018). https://doi.org/10.1126/scisignal.aat7650.Full Text Link to Item
-
Wang, Jialu, Clarice Gareri, and Howard A. Rockman. “G-Protein-Coupled Receptors in Heart Disease.” Circ Res 123, no. 6 (August 31, 2018): 716–35. https://doi.org/10.1161/CIRCRESAHA.118.311403.Full Text Link to Item
-
Wisler, James W., Howard A. Rockman, and Robert J. Lefkowitz. “Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery.” Circulation 137, no. 22 (May 29, 2018): 2315–17. https://doi.org/10.1161/CIRCULATIONAHA.117.028194.Full Text Link to Item
-
Wang, Jialu, Kenji Hanada, Clarice Gareri, and Howard A. Rockman. “Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling.” J Cell Biochem 119, no. 4 (April 2018): 3586–97. https://doi.org/10.1002/jcb.26552.Full Text Link to Item
-
Rockman, Howard A. “We're listening.” Jci Insight 3, no. 2 (January 25, 2018). https://doi.org/10.1172/jci.insight.99456.Full Text Link to Item
-
Wang, Jialu, Kenji Hanada, Dean P. Staus, Michael A. Makara, Giri Raj Dahal, Qiang Chen, Andrea Ahles, Stefan Engelhardt, and Howard A. Rockman. “Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling.” Nat Commun 8, no. 1 (November 22, 2017): 1706. https://doi.org/10.1038/s41467-017-01855-z.Full Text Link to Item
-
Jean-Charles, Pierre-Yves, Samuel Mon-Wei Yu, Dennis Abraham, Reddy Peera Kommaddi, Lan Mao, Ryan T. Strachan, Zhu-Shan Zhang, et al. “Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.” Jci Insight 2, no. 17 (September 7, 2017). https://doi.org/10.1172/jci.insight.95998.Full Text Link to Item
-
Rockman, Howard A. “לְדוֹר וָדוֹר.” J Clin Invest 127, no. 6 (June 1, 2017): 2019–20. https://doi.org/10.1172/JCI94813.Full Text Link to Item
-
Rockman, Howard A. “A successful launch.” Jci Insight 2, no. 2 (January 26, 2017): e92800. https://doi.org/10.1172/jci.insight.92800.Full Text Link to Item
-
Abraham, Dennis M., Robert T. Davis, Chad M. Warren, Lan Mao, Beata M. Wolska, R John Solaro, and Howard A. Rockman. “β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility.” Proc Natl Acad Sci U S A 113, no. 50 (December 13, 2016): 14426–31. https://doi.org/10.1073/pnas.1609308113.Full Text Link to Item
-
Watson, Lewis J., Kevin M. Alexander, Maradumane L. Mohan, Amber L. Bowman, Supachoke Mangmool, Kunhong Xiao, Sathyamangla V. Naga Prasad, and Howard A. Rockman. “Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation.” Cell Signal 28, no. 10 (October 2016): 1580–92. https://doi.org/10.1016/j.cellsig.2016.05.006.Full Text Link to Item
-
Hodavance, Sima Y., Clarice Gareri, Rachel D. Torok, and Howard A. Rockman. “G Protein-coupled Receptor Biased Agonism.” J Cardiovasc Pharmacol 67, no. 3 (March 2016): 193–202. https://doi.org/10.1097/FJC.0000000000000356.Full Text Link to Item
-
Rockman, H. A. “New kid on the block.” J Clin Invest 126, no. 1 (January 4, 2016): 1–2. https://doi.org/10.1172/JCI85448.Full Text Link to Item
-
Kirk, Jonathan A., Khalid Chakir, Kyoung Hwan Lee, Edward Karst, Ronald J. Holewinski, Gianluigi Pironti, Richard S. Tunin, et al. “Pacemaker-induced transient asynchrony suppresses heart failure progression.” Sci Transl Med 7, no. 319 (December 23, 2015): 319ra207. https://doi.org/10.1126/scitranslmed.aad2899.Full Text Link to Item
-
Wisler, James W., Emily M. Harris, Michael Raisch, Lan Mao, Jihee Kim, Howard A. Rockman, and Robert J. Lefkowitz. “The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.” Am J Physiol Heart Circ Physiol 309, no. 9 (November 2015): H1516–27. https://doi.org/10.1152/ajpheart.00291.2015.Full Text Link to Item
-
Xu, Wenjing, Tomasa Barrientos, Lan Mao, Howard A. Rockman, Anthony A. Sauve, and Nancy C. Andrews. “Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart.” Cell Rep 13, no. 3 (October 20, 2015): 533–45. https://doi.org/10.1016/j.celrep.2015.09.023.Full Text Link to Item
-
Pironti, Gianluigi, Ryan T. Strachan, Dennis Abraham, Samuel Mon-Wei Yu, Minyong Chen, Wei Chen, Kenji Hanada, Lan Mao, Lewis J. Watson, and Howard A. Rockman. “Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.” Circulation 131, no. 24 (June 16, 2015): 2120–30. https://doi.org/10.1161/CIRCULATIONAHA.115.015687.Full Text Link to Item
-
Tang, Wei, Ryan T. Strachan, Robert J. Lefkowitz, and Howard A. Rockman. “Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.” J Biol Chem 289, no. 41 (October 10, 2014): 28271–83. https://doi.org/10.1074/jbc.M114.585067.Full Text Link to Item
-
Lee, Teresa E., Lin Yu, Matthew J. Wolf, and Howard A. Rockman. “Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila.” Genetics 198, no. 2 (October 2014): 591–603. https://doi.org/10.1534/genetics.114.166777.Full Text Link to Item
-
Rockman, Howard A. “Happy birthday JCI.” J Clin Invest 124, no. 10 (October 2014): 4135–36. https://doi.org/10.1172/JCI78708.Full Text Link to Item
-
Kim, Il-Man, Yongchao Wang, Kyoung-Mi Park, Yaoping Tang, Jian-Peng Teoh, Joseph Vinson, Christopher J. Traynham, et al. “β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing.” Circ Res 114, no. 5 (February 28, 2014): 833–44. https://doi.org/10.1161/CIRCRESAHA.114.302766.Full Text Link to Item
-
Rockman, Howard A. “Waste not, want not.” J Clin Invest 124, no. 2 (February 2014): 463. https://doi.org/10.1172/JCI75011.Full Text Link to Item
-
Santacruz, Lucia, Alejandro Hernandez, Jeffrey Nienaber, Rajashree Mishra, Miguel Pinilla, James Burchette, Lan Mao, Howard A. Rockman, and Danny O. Jacobs. “Normal cardiac function in mice with supraphysiological cardiac creatine levels.” Am J Physiol Heart Circ Physiol 306, no. 3 (February 2014): H373–81. https://doi.org/10.1152/ajpheart.00411.2013.Full Text Link to Item
-
Ashton, Jeffrey R., Nicholas Befera, Darin Clark, Yi Qi, Lan Mao, Howard A. Rockman, G Allan Johnson, and Cristian T. Badea. “Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent.” Contrast Media Mol Imaging 9, no. 2 (2014): 161–68. https://doi.org/10.1002/cmmi.1557.Full Text Link to Item
-
Rockman, H. A. “Tempus fugit.” J Clin Invest 123, no. 3 (March 1, 2013): 935–36. https://doi.org/10.1172/JCI69370.Full Text Link to Item
-
Tang, Hao, Kunhong Xiao, Lan Mao, Howard A. Rockman, and Douglas A. Marchuk. “Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.” J Mol Cell Cardiol 54 (January 2013): 101–11. https://doi.org/10.1016/j.yjmcc.2012.10.004.Full Text Link to Item
-
Rockman, H. A. “Clinical medicine.” Journal of Clinical Investigation 122, no. 12 (December 3, 2012): 4303. https://doi.org/10.1172/JCI67619.Full Text
-
Kim, Ki-Seok, Dennis Abraham, Barbara Williams, Jonathan D. Violin, Lan Mao, and Howard A. Rockman. “β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.” Am J Physiol Heart Circ Physiol 303, no. 8 (October 15, 2012): H1001–10. https://doi.org/10.1152/ajpheart.00475.2012.Full Text Link to Item
-
Lee, Chang-Lung, Everett J. Moding, Kyle C. Cuneo, Yifan Li, Julie M. Sullivan, Lan Mao, Iman Washington, et al. “p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.” Sci Signal 5, no. 234 (July 24, 2012): ra52. https://doi.org/10.1126/scisignal.2002918.Full Text Link to Item
-
Houser, Steven R., Kenneth B. Margulies, Anne M. Murphy, Francis G. Spinale, Gary S. Francis, Sumanth D. Prabhu, Howard A. Rockman, et al. “Animal models of heart failure: a scientific statement from the American Heart Association.” Circ Res 111, no. 1 (June 22, 2012): 131–50. https://doi.org/10.1161/RES.0b013e3182582523.Full Text Link to Item
-
Lefkowitz, Robert, Joseph Goldstein, and Michael Brown. “A conversation with Robert Lefkowitz, Joseph Goldstein, and Michael Brown. Interview by Ushma S. Neil and Howard A. Rockman.” J Clin Invest 122, no. 5 (May 2012): 1586–87. https://doi.org/10.1172/jci64244.Full Text Link to Item
-
Rockman, Howard A. “Great expectations.” J Clin Invest 122, no. 4 (April 2012): 1133. https://doi.org/10.1172/JCI63462.Full Text Link to Item
-
Casad, Michelle E., Lin Yu, Joseph P. Daniels, Matthew J. Wolf, and Howard A. Rockman. “Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy.” Mol Genet Genomics 287, no. 4 (April 2012): 351–60. https://doi.org/10.1007/s00438-012-0684-x.Full Text Link to Item
-
Rockman, Howard A. “Tradition, tradition.” J Clin Invest 122, no. 3 (March 2012): 785–86. https://doi.org/10.1172/JCI63105.Full Text Link to Item
-
Caplan, Arthur L., Howard A. Rockman, and Laurence A. Turka. “Editorial position on publishing articles on human organ transplantation.” J Clin Invest 122, no. 1 (January 2012): 2. https://doi.org/10.1172/JCI61904.Full Text Link to Item
-
Casad, Michelle E., Dennis Abraham, Il-Man Kim, Stephan Frangakis, Brian Dong, Na Lin, Matthew J. Wolf, and Howard A. Rockman. “Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster.” Genetics 189, no. 3 (November 2011): 861–70. https://doi.org/10.1534/genetics.111.131482.Full Text Link to Item
-
Grotegut, Chad A., Amy P. Murtha, and Howard A. Rockman. “MSH-releasing Inhibitor Factor (pro-leu-gly-NH2) Acts as an Allosteric Activator for Oxytocin-induced MAPK Signaling but Does Not Affect Uterine Contractility.” Journal of Womens Health 20, no. 10 (October 1, 2011): 1392–1392.Link to Item
-
Noor, Nabila, Chetan B. Patel, and Howard A. Rockman. “Β-arrestin: a signaling molecule and potential therapeutic target for heart failure.” J Mol Cell Cardiol 51, no. 4 (October 2011): 534–41. https://doi.org/10.1016/j.yjmcc.2010.11.005.Full Text Link to Item
-
Shenoy, Sudha K., and Howard A. Rockman. “Cardiovascular biology: heart fails without pump partner.” Nature 477, no. 7366 (September 28, 2011): 546–47. https://doi.org/10.1038/477546a.Full Text Link to Item
-
Wolf, Matthew J., and Howard A. Rockman. “Drosophila, genetic screens, and cardiac function.” Circ Res 109, no. 7 (September 16, 2011): 794–806. https://doi.org/10.1161/CIRCRESAHA.111.244897.Full Text Link to Item
-
Rockman, Howard A., and Robert J. Lefkowitz. “Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling.” Circ Res 109, no. 2 (July 8, 2011): 202–4. https://doi.org/10.1161/CIRCRESAHA.110.231126.Full Text Link to Item
-
Lin, Na, Nima Badie, Lin Yu, Dennis Abraham, Heping Cheng, Nenad Bursac, Howard A. Rockman, and Matthew J. Wolf. “A method to measure myocardial calcium handling in adult Drosophila.” Circ Res 108, no. 11 (May 27, 2011): 1306–15. https://doi.org/10.1161/CIRCRESAHA.110.238105.Full Text Link to Item
-
Rajagopal, Sudarshan, Jeff Kovacs, Cristian Badea, G Allan Johnson, Howard A. Rockman, Claude A. Piantadosi, and Robert J. Lefkowitz. “BETA-ARRESTINS REGULATE SIGNALING BY BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN PULMONARY ARTERIAL HYPERTENSION.” Journal of the American College of Cardiology 57, no. 14 (April 2011): E2046–E2046. https://doi.org/10.1016/s0735-1097(11)62046-9.Full Text
-
Grotegut, Chad A., Liping Feng, Lan Mao, R Phillips Heine, Amy P. Murtha, and Howard A. Rockman. “β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.” Am J Physiol Endocrinol Metab 300, no. 3 (March 2011): E468–77. https://doi.org/10.1152/ajpendo.00390.2010.Full Text Link to Item
-
Patel, Chetan B., Nabila Noor, and Howard A. Rockman. “Functional selectivity in adrenergic and angiotensin signaling systems.” Mol Pharmacol 78, no. 6 (December 2010): 983–92. https://doi.org/10.1124/mol.110.067066.Full Text Link to Item
-
Alexander, Kevin M., Supachoke Mangmool, Chetan B. Patel, Kunhong Xiao, and Howard A. Rockman. “Phosphoinositde 3-Kinase Regulates beta 2-Adrenergic Receptor Stimulated Epidermal Growth Factor Receptor Transactivation.” Circulation 122, no. 21 (November 23, 2010).Link to Item
-
Tilley, Douglas G., Anny D. Nguyen, and Howard A. Rockman. “Troglitazone stimulates beta-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor.” Biochem Biophys Res Commun 396, no. 4 (June 11, 2010): 921–26. https://doi.org/10.1016/j.bbrc.2010.05.023.Full Text Link to Item
-
Rakesh, Kriti, ByungSu Yoo, Il-Man Kim, Natasha Salazar, Ki-Seok Kim, and Howard A. Rockman. “beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress.” Sci Signal 3, no. 125 (June 8, 2010): ra46. https://doi.org/10.1126/scisignal.2000769.Full Text Link to Item
-
Rockman, H. A., and A. M. VanHook. “Science signaling podcast: 8 June 2010.” Science Signaling 3, no. 125 (June 8, 2010). https://doi.org/10.1126/scisignal.3125pc12.Full Text
-
Kim, Byung-Eun, Michelle L. Turski, Yasuhiro Nose, Michelle Casad, Howard A. Rockman, and Dennis J. Thiele. “Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.” Cell Metab 11, no. 5 (May 5, 2010): 353–63. https://doi.org/10.1016/j.cmet.2010.04.003.Full Text Link to Item
-
Mangmool, Supachoke, Arun K. Shukla, and Howard A. Rockman. “beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation.” J Cell Biol 189, no. 3 (May 3, 2010): 573–87. https://doi.org/10.1083/jcb.200911047.Full Text Link to Item
-
Kim, Il-Man, Matthew J. Wolf, and Howard A. Rockman. “Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.” Circ Res 106, no. 7 (April 16, 2010): 1233–43. https://doi.org/10.1161/CIRCRESAHA.109.213785.Full Text Link to Item
-
Bucholz, Elizabeth, Ketan Ghaghada, Yi Qi, Srinivasan Mukundan, Howard A. Rockman, and G Allan Johnson. “Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA.” Magn Reson Med 63, no. 4 (April 2010): 979–87. https://doi.org/10.1002/mrm.22259.Full Text Link to Item
-
McNamara, Erin R., Lan Mao, Susan Poulton, Howard A. Rockman, Trinity J. Bivalacqua, Stephen J. Freedland, and Craig F. Donatucci. “889 EFFECT OF EXERCISE ON ERECTILE FUNCTION AFTER BILATERAL NERVE CRUSH INJURY IN A RAT MODEL.” Journal of Urology 183, no. 4S (April 2010). https://doi.org/10.1016/j.juro.2010.02.1645.Full Text
-
Seth, Malini, Zhu-Shan Zhang, Lan Mao, Victoria Graham, Jarrett Burch, Jonathan Stiber, Leonidas Tsiokas, et al. “TRPC1 channels are critical for hypertrophic signaling in the heart.” Circ Res 105, no. 10 (November 6, 2009): 1023–30. https://doi.org/10.1161/CIRCRESAHA.109.206581.Full Text Link to Item
-
Yoo, ByungSu, Anthony Lemaire, Supachoke Mangmool, Matthew J. Wolf, Antonio Curcio, Lan Mao, and Howard A. Rockman. “Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction.” Am J Physiol Heart Circ Physiol 297, no. 4 (October 2009): H1377–86. https://doi.org/10.1152/ajpheart.00504.2009.Full Text Link to Item
-
Wheeler, Ferrin C., Hao Tang, Odessa A. Marks, Tracy N. Hadnott, Pei-Lun Chu, Lan Mao, Howard A. Rockman, and Douglas A. Marchuk. “Tnni3k modifies disease progression in murine models of cardiomyopathy.” Plos Genet 5, no. 9 (September 2009): e1000647. https://doi.org/10.1371/journal.pgen.1000647.Full Text Link to Item
-
Tilley, Douglas G., Il-Man Kim, Priyesh A. Patel, Jonathan D. Violin, and Howard A. Rockman. “beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling.” J Biol Chem 284, no. 30 (July 24, 2009): 20375–86. https://doi.org/10.1074/jbc.M109.005793.Full Text Link to Item
-
Pandya, Kumar, Kristine Porter, Howard A. Rockman, and Oliver Smithies. “Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain.” Eur J Heart Fail 11, no. 7 (July 2009): 648–52. https://doi.org/10.1093/eurjhf/hfp073.Full Text Link to Item
-
Fernandez, Liliana, Douglas A. Marchuk, Jennifer L. Moran, David R. Beier, and Howard A. Rockman. “An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15.” Mamm Genome 20, no. 5 (May 2009): 296–304. https://doi.org/10.1007/s00335-009-9184-7.Full Text Link to Item
-
Lima, Brian, Gregory K. W. Lam, Liang Xie, Diana L. Diesen, Nestor Villamizar, Jeffrey Nienaber, Emily Messina, et al. “Endogenous S-nitrosothiols protect against myocardial injury.” Proc Natl Acad Sci U S A 106, no. 15 (April 14, 2009): 6297–6302. https://doi.org/10.1073/pnas.0901043106.Full Text Link to Item
-
Acehan, Devrim, Zaza Khuchua, Riekelt H. Houtkooper, Ashim Malhotra, Johanna Kaufman, Frédéric M. Vaz, Mindong Ren, Howard A. Rockman, David L. Stokes, and Michael Schlame. “Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria.” Mitochondrion 9, no. 2 (April 2009): 86–95. https://doi.org/10.1016/j.mito.2008.12.001.Full Text Link to Item
-
Grotegut, Chad A., Amy P. Murtha, and Howard A. Rockman. “Beta-Arrestin Mediates Oxytocin Receptor Desensitization and MAPK Signaling Following Oxytocin Stimulation.” Reproductive Sciences 16, no. 3 (March 1, 2009): 104A-104A.Link to Item
-
Patel, Priyesh A., Douglas G. Tilley, and Howard A. Rockman. “Physiologic and cardiac roles of beta-arrestins.” J Mol Cell Cardiol 46, no. 3 (March 2009): 300–308. https://doi.org/10.1016/j.yjmcc.2008.11.015.Full Text Link to Item
-
Mehra, Mandeep R., Howard A. Rockman, and Barry H. Greenberg. “Highlights of the 2008 Scientific Sessions of the Heart Failure Society of America. Toronto, Ontario, Canada, September 20-23, 2008.” J Am Coll Cardiol 53, no. 6 (February 10, 2009): 514–22. https://doi.org/10.1016/j.jacc.2008.11.003.Full Text Link to Item
-
Chen, J., and H. A. Rockman. “Receptor signaling pathways in heart failure: Transgenic mouse models,” December 1, 2008, 89–111. https://doi.org/10.1007/978-1-84628-782-4_10.Full Text
-
Patel, Priyesh A., Douglas G. Tilley, and Howard A. Rockman. “Beta-arrestin-mediated signaling in the heart.” Circ J 72, no. 11 (November 2008): 1725–29. https://doi.org/10.1253/circj.cj-08-0734.Full Text Link to Item
-
Francois, Helene, Natalia Makhanova, Philip Ruiz, Jonathan Ellison, Lan Mao, Howard A. Rockman, and Thomas M. Coffman. “A role for the thromboxane receptor in L-NAME hypertension.” Am J Physiol Renal Physiol 295, no. 4 (October 2008): F1096–1102. https://doi.org/10.1152/ajprenal.00369.2007.Full Text Link to Item
-
Wolf, Matthew J., and Howard A. Rockman. “Drosophila melanogaster as a model system for genetics of postnatal cardiac function.” Drug Discov Today Dis Models 5, no. 3 (October 1, 2008): 117–23. https://doi.org/10.1016/j.ddmod.2009.02.002.Full Text Link to Item
-
Kim, Il-Man, Douglas G. Tilley, Juhsien Chen, Natasha C. Salazar, Erin J. Whalen, Jonathan D. Violin, and Howard A. Rockman. “Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.” Proc Natl Acad Sci U S A 105, no. 38 (September 23, 2008): 14555–60. https://doi.org/10.1073/pnas.0804745105.Full Text Link to Item
-
Pandya, Kumar, John Cowhig, Joe Brackhan, Hyung Suk Kim, John Hagaman, Mauricio Rojas, Charles W. Carter, et al. “Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.” Proc Natl Acad Sci U S A 105, no. 35 (September 2, 2008): 13063–68. https://doi.org/10.1073/pnas.0805120105.Full Text Link to Item
-
Ream, Margie A., Rashmi Chandra, Mary Peavey, Alisa M. Ray, Suzanne Roffler-Tarlov, Hyung-Gun Kim, William C. Wetsel, Howard A. Rockman, and Dona M. Chikaraishi. “High oxygen prevents fetal lethality due to lack of catecholamines.” Am J Physiol Regul Integr Comp Physiol 295, no. 3 (September 2008): R942–53. https://doi.org/10.1152/ajpregu.00860.2007.Full Text Link to Item
-
Barki-Harrington, Liza, and Howard A. Rockman. “Beta-arrestins: multifunctional cellular mediators.” Physiology (Bethesda) 23 (February 2008): 17–22. https://doi.org/10.1152/physiol.00042.2007.Full Text Link to Item
-
Mehra, Mandeep R., Howard A. Rockman, and Barry H. Greenberg. “Highlights of the 2007 Scientific Meeting of the Heart Failure Society of America: Washington, DC, September 16-19, 2007.” J Am Coll Cardiol 51, no. 3 (January 22, 2008): 320–27. https://doi.org/10.1016/j.jacc.2007.11.026.Full Text Link to Item
-
Esposito, Giovanni, Cinzia Perrino, Tohru Ozaki, Hideyuki Takaoka, Nicole Defer, Maria Piera Petretta, Maria Carmen De Angelis, et al. “Increased myocardial contractility and enhanced exercise function in transgenic mice overexpressing either adenylyl cyclase 5 or 8.” Basic Res Cardiol 103, no. 1 (January 2008): 22–30. https://doi.org/10.1007/s00395-007-0688-6.Full Text Link to Item
-
Allikian, Michael J., Gira Bhabha, Patrick Dospoy, Ahlke Heydemann, Pearl Ryder, Judy U. Earley, Matthew J. Wolf, Howard A. Rockman, and Elizabeth M. McNally. “Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants.” Hum Mol Genet 16, no. 23 (December 1, 2007): 2933–43. https://doi.org/10.1093/hmg/ddm254.Full Text Link to Item
-
Chin, Bennett B., Scott D. Metzler, Anthony Lemaire, Antonio Curcio, Sreekanth Vemulapalli, Kim L. Greer, Neil A. Petry, et al. “Left ventricular functional assessment in mice: feasibility of high spatial and temporal resolution ECG-gated blood pool SPECT.” Radiology 245, no. 2 (November 2007): 440–48. https://doi.org/10.1148/radiol.2452061973.Full Text Link to Item
-
Salzler, H. R., R. Griffiths, P. Ruiz, L. Chi, C. Frey, D. A. Marchuk, H. A. Rockman, and T. H. Le. “Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus.” Kidney Int 72, no. 10 (November 2007): 1226–32. https://doi.org/10.1038/sj.ki.5002519.Full Text Link to Item
-
Mohler, Peter J., Jane A. Healy, Hui Xue, Annibale A. Puca, Crystal F. Kline, R Rand Allingham, Evangelia G. Kranias, Howard A. Rockman, and Vann Bennett. “Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence.” Plos One 2, no. 10 (October 17, 2007): e1051. https://doi.org/10.1371/journal.pone.0001051.Full Text Link to Item
-
Perrino, Cinzia, and Howard A. Rockman. “Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure.” Curr Opin Cardiol 22, no. 5 (September 2007): 443–49. https://doi.org/10.1097/HCO.0b013e3282294d72.Full Text Link to Item
-
Noma, Takahisa, Anthony Lemaire, Sathyamangla V. Naga Prasad, Liza Barki-Harrington, Douglas G. Tilley, Juhsien Chen, Philippe Le Corvoisier, et al. “Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.” J Clin Invest 117, no. 9 (September 2007): 2445–58. https://doi.org/10.1172/JCI31901.Full Text Open Access Copy Link to Item
-
Whalen, Erin J., Matthew W. Foster, Akio Matsumoto, Kentaro Ozawa, Jonathan D. Violin, Loretta G. Que, Chris D. Nelson, et al. “Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.” Cell 129, no. 3 (May 4, 2007): 511–22. https://doi.org/10.1016/j.cell.2007.02.046.Full Text Link to Item
-
Salazar, Natasha C., Juhsien Chen, and Howard A. Rockman. “Cardiac GPCRs: GPCR signaling in healthy and failing hearts.” Biochim Biophys Acta 1768, no. 4 (April 2007): 1006–18. https://doi.org/10.1016/j.bbamem.2007.02.010.Full Text Link to Item
-
Donahue, M. P., D. A. Marchuk, and H. A. Rockman. “Reply.” Journal of the American College of Cardiology 49, no. 10 (March 13, 2007): 1106–7. https://doi.org/10.1016/j.jacc.2006.12.019.Full Text
-
Badea, Cristian T., Laurence W. Hedlund, Julie F Boslego Mackel, Lan Mao, Howard A. Rockman, and G Allan Johnson. “Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice.” Mol Imaging 6, no. 4 (2007): 261–68.Link to Item
-
Rajagopal, Keshava, Erin J. Whalen, Jonathan D. Violin, Jonathan A. Stiber, Paul B. Rosenberg, Richard T. Premont, Thomas M. Coffman, Howard A. Rockman, and Robert J. Lefkowitz. “Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.” Proc Natl Acad Sci U S A 103, no. 44 (October 31, 2006): 16284–89. https://doi.org/10.1073/pnas.0607583103.Full Text Link to Item
-
Donahue, Mark P., Douglas A. Marchuk, and Howard A. Rockman. “Redefining heart failure: the utility of genomics.” J Am Coll Cardiol 48, no. 7 (October 3, 2006): 1289–98. https://doi.org/10.1016/j.jacc.2006.05.062.Full Text Link to Item
-
Curcio, Antonio, Takahisa Noma, Sathyamangla V. Naga Prasad, Matthew J. Wolf, Anthony Lemaire, Cinzia Perrino, Lan Mao, and Howard A. Rockman. “Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling.” Am J Physiol Heart Circ Physiol 291, no. 4 (October 2006): H1754–60. https://doi.org/10.1152/ajpheart.01199.2005.Full Text Link to Item
-
Seubert, John M., Christopher J. Sinal, Joan Graves, Laura M. DeGraff, J Alyce Bradbury, Craig R. Lee, Kerry Goralski, et al. “Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function.” Circ Res 99, no. 4 (August 18, 2006): 442–50. https://doi.org/10.1161/01.RES.0000237390.92932.37.Full Text Link to Item
-
Perrino, Cinzia, Howard A. Rockman, and Massimo Chiariello. “Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure.” Vascul Pharmacol 45, no. 2 (August 2006): 77–85. https://doi.org/10.1016/j.vph.2006.01.018.Full Text Link to Item
-
Gurley, Susan B., Alicia Allred, Thu H. Le, Robert Griffiths, Lan Mao, Nisha Philip, Timothy A. Haystead, et al. “Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.” J Clin Invest 116, no. 8 (August 2006): 2218–25. https://doi.org/10.1172/JCI16980.Full Text Link to Item
-
Perrino, Cinzia, Sathyamangla V. Naga Prasad, Lan Mao, Takahisa Noma, Zhen Yan, Hyung-Suk Kim, Oliver Smithies, and Howard A. Rockman. “Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.” J Clin Invest 116, no. 6 (June 2006): 1547–60. https://doi.org/10.1172/JCI25397.Full Text Link to Item
-
Tachibana, Hideo, Cinzia Perrino, Hideyuki Takaoka, Roger J. Davis, Sathyamangla V. Naga Prasad, and Howard A. Rockman. “JNK1 is required to preserve cardiac function in the early response to pressure overload.” Biochem Biophys Res Commun 343, no. 4 (May 19, 2006): 1060–66. https://doi.org/10.1016/j.bbrc.2006.03.065.Full Text Link to Item
-
Tilley, Douglas G., and Howard A. Rockman. “Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment.” Expert Rev Cardiovasc Ther 4, no. 3 (May 2006): 417–32. https://doi.org/10.1586/14779072.4.3.417.Full Text Link to Item
-
Volovyk, Zoya M., Matthew J. Wolf, Sathyamangla V Naga Prasad, and Howard A. Rockman. “Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover.” J Biol Chem 281, no. 14 (April 7, 2006): 9773–80. https://doi.org/10.1074/jbc.M511435200.Full Text Link to Item
-
Perrino, Cinzia, and Howard A. Rockman. “GATA4 and the two sides of gene expression reprogramming.” Circ Res 98, no. 6 (March 31, 2006): 715–16. https://doi.org/10.1161/01.RES.0000217593.07196.af.Full Text Link to Item
-
Wolf, Matthew J., Hubert Amrein, Joseph A. Izatt, Michael A. Choma, Mary C. Reedy, and Howard A. Rockman. “Drosophila as a model for the identification of genes causing adult human heart disease.” Proc Natl Acad Sci U S A 103, no. 5 (January 31, 2006): 1394–99. https://doi.org/10.1073/pnas.0507359103.Full Text Link to Item
-
Badea, Cristian T., Elizabeth Bucholz, Laurence W. Hedlund, Howard A. Rockman, and G Allan Johnson. “Imaging methods for morphological and functional phenotyping of the rodent heart.” Toxicol Pathol 34, no. 1 (2006): 111–17. https://doi.org/10.1080/01926230500404126.Full Text Link to Item
-
Francois, H., K. Athirakul, D. Howell, R. Dash, L. Mao, H. S. Kim, H. A. Rockman, G. A. FitzGerald, B. H. Koller, and T. M. Coffman. “NSAIDs and cardiovascular risk - Reply [2].” Cell Metabolism 2, no. 6 (December 1, 2005): 339–40. https://doi.org/10.1016/j.cmet.2005.11.009.Full Text
-
Rajagopal, Keshava, Robert J. Lefkowitz, and Howard A. Rockman. “When 7 transmembrane receptors are not G protein-coupled receptors.” J Clin Invest 115, no. 11 (November 2005): 2971–74. https://doi.org/10.1172/JCI26950.Full Text Open Access Copy Link to Item
-
Perrino, C., G. Esposito, and H. A. Rockman. “Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction.” Panminerva Med 47, no. 3 (September 2005): 143–55.Link to Item
-
Francois, Helene, Krairerk Athirakul, David Howell, Rajesh Dash, Lan Mao, Hyung-Suk Kim, Howard A. Rockman, Garret A. Fitzgerald, Beverly H. Koller, and Thomas M. Coffman. “Prostacyclin protects against elevated blood pressure and cardiac fibrosis.” Cell Metab 2, no. 3 (September 2005): 201–7. https://doi.org/10.1016/j.cmet.2005.08.005.Full Text Link to Item
-
Chen, Zhiqiang, Matthew W. Foster, Jian Zhang, Lan Mao, Howard A. Rockman, Toshihiro Kawamoto, Kyoko Kitagawa, Keiichi I. Nakayama, Douglas T. Hess, and Jonathan S. Stamler. “An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.” Proc Natl Acad Sci U S A 102, no. 34 (August 23, 2005): 12159–64. https://doi.org/10.1073/pnas.0503723102.Full Text Link to Item
-
Naga Prasad, Sathyamangla V., Arundathi Jayatilleke, Aasakiran Madamanchi, and Howard A. Rockman. “Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.” Nat Cell Biol 7, no. 8 (August 2005): 785–96. https://doi.org/10.1038/ncb1278.Full Text Link to Item
-
Perrino, Cinzia, Sathyamangla V. Naga Prasad, Mrinali Patel, Matthew J. Wolf, and Howard A. Rockman. “Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression.” J Am Coll Cardiol 45, no. 11 (June 7, 2005): 1862–70. https://doi.org/10.1016/j.jacc.2005.02.062.Full Text Link to Item
-
Wheeler, Ferrin C., Liliana Fernandez, Kerri M. Carlson, Matthew J. Wolf, Howard A. Rockman, and Douglas A. Marchuk. “QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival.” Mamm Genome 16, no. 6 (June 2005): 414–23. https://doi.org/10.1007/s00335-005-2468-7.Full Text Link to Item
-
Perrino, Cinzia, Sathyamangla V. Naga Prasad, Jacob N. Schroder, Jonathan A. Hata, Carmelo Milano, and Howard A. Rockman. “Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex.” Circulation 111, no. 20 (May 24, 2005): 2579–87. https://doi.org/10.1161/CIRCULATIONAHA.104.508796.Full Text Link to Item
-
Nassar, Rashid, Nadia N. Malouf, Lan Mao, Howard A. Rockman, Annette E. Oakeley, James R. Frye, J René Herlong, Stephen P. Sanders, and Page A. W. Anderson. “cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform.” Am J Physiol Heart Circ Physiol 288, no. 3 (March 2005): H1147–56. https://doi.org/10.1152/ajpheart.00140.2004.Full Text Link to Item
-
Tachibana, Hideo, Sathyamangla V. Naga Prasad, Robert J. Lefkowitz, Walter J. Koch, and Howard A. Rockman. “Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.” Circulation 111, no. 5 (February 8, 2005): 591–97. https://doi.org/10.1161/01.CIR.0000142291.70954.DF.Full Text Open Access Copy Link to Item
-
Bosch, Bianca J. C. van den, Caroline M. M. van den Burg, Kees Schoonderwoerd, Patrick J. Lindsey, Hans R. Scholte, René F. M. de Coo, Eva van Rooij, Howard A. Rockman, Pieter A. Doevendans, and Hubert J. M. Smeets. “Regional absence of mitochondria causing energy depletion in the myocardium of muscle LIM protein knockout mice.” Cardiovasc Res 65, no. 2 (February 1, 2005): 411–18. https://doi.org/10.1016/j.cardiores.2004.10.025.Full Text Link to Item
-
Skavdahl, Maryanne, Charles Steenbergen, James Clark, Page Myers, Tracy Demianenko, Lan Mao, Howard A. Rockman, Kenneth S. Korach, and Elizabeth Murphy. “Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy.” Am J Physiol Heart Circ Physiol 288, no. 2 (February 2005): H469–76. https://doi.org/10.1152/ajpheart.00723.2004.Full Text Link to Item
-
Martindale, Joshua J., Jason A. Wall, Diana M. Martinez-Longoria, Prafulla Aryal, Howard A. Rockman, Yiru Guo, Roberto Bolli, and Christopher C. Glembotski. “Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo.” J Biol Chem 280, no. 1 (January 7, 2005): 669–76. https://doi.org/10.1074/jbc.M406690200.Full Text Link to Item
-
Wolf, Matthew J., Hideo Tachibana, and Howard A. Rockman. “Methods for the detection of altered beta-adrenergic receptor signaling pathways in hypertrophied hearts.” Methods Mol Med 112 (2005): 353–62. https://doi.org/10.1385/1-59259-879-x:353.Full Text Link to Item
-
Kedar, Vishram, Holly McDonough, Ranjana Arya, Hui-Hua Li, Howard A. Rockman, and Cam Patterson. “Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.” Proc Natl Acad Sci U S A 101, no. 52 (December 28, 2004): 18135–40. https://doi.org/10.1073/pnas.0404341102.Full Text Link to Item
-
Seubert, John, Baichun Yang, J Alyce Bradbury, Joan Graves, Laura M. Degraff, Scott Gabel, Rebecca Gooch, et al. “Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway.” Circ Res 95, no. 5 (September 3, 2004): 506–14. https://doi.org/10.1161/01.RES.0000139436.89654.c8.Full Text Link to Item
-
Barki-Harrington, Liza, Cinzia Perrino, and Howard A. Rockman. “Network integration of the adrenergic system in cardiac hypertrophy.” Cardiovasc Res 63, no. 3 (August 15, 2004): 391–402. https://doi.org/10.1016/j.cardiores.2004.03.011.Full Text Link to Item
-
Tong, Haiyan, Howard A. Rockman, Walter J. Koch, Charles Steenbergen, and Elizabeth Murphy. “G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning.” Circ Res 94, no. 8 (April 30, 2004): 1133–41. https://doi.org/10.1161/01.RES.0000126048.32383.6B.Full Text Link to Item
-
Caron, Kathleen M. I., Leighton R. James, Hyung-Suk Kim, Josh Knowles, Rick Uhlir, Lan Mao, John R. Hagaman, Wayne Cascio, Howard Rockman, and Oliver Smithies. “Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene.” Proc Natl Acad Sci U S A 101, no. 9 (March 2, 2004): 3106–11. https://doi.org/10.1073/pnas.0307333101.Full Text Link to Item
-
Francois, Helene, Krairerk Athirakul, Lan Mao, Howard Rockman, and Thomas M. Coffman. “Role for thromboxane receptors in angiotensin-II-induced hypertension.” Hypertension 43, no. 2 (February 2004): 364–69. https://doi.org/10.1161/01.HYP.0000112225.27560.24.Full Text Link to Item
-
Lemaire, A., and H. A. Rockman. “The role of G-protein-coupled receptors in heart failure.” Drug Discovery Today: Disease Mechanisms 1, no. 1 (January 1, 2004): 37–43. https://doi.org/10.1016/j.ddmec.2004.08.013.Full Text
-
Le Corvoisier, Philippe, Hyun-Young Park, Kerri M. Carlson, Douglas A. Marchuk, and Howard A. Rockman. “Multiple quantitative trait loci modify the heart failure phenotype in murine cardiomyopathy.” Hum Mol Genet 12, no. 23 (December 1, 2003): 3097–3107. https://doi.org/10.1093/hmg/ddg333.Full Text Link to Item
-
Keys, Janelle R., Emily A. Greene, Chris J. Cooper, Sathyamangla V. Naga Prasad, Howard A. Rockman, and Walter J. Koch. “Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1.” Am J Physiol Heart Circ Physiol 285, no. 5 (November 2003): H2201–11. https://doi.org/10.1152/ajpheart.00112.2003.Full Text Link to Item
-
Blaxall, Burns C., Rainer Spang, Howard A. Rockman, and Walter J. Koch. “Differential myocardial gene expression in the development and rescue of murine heart failure.” Physiol Genomics 15, no. 2 (October 17, 2003): 105–14. https://doi.org/10.1152/physiolgenomics.00087.2003.Full Text Link to Item
-
Nienaber, Jeffrey J., Hideo Tachibana, Sathyamangla V. Naga Prasad, Giovanni Esposito, Dianqing Wu, Lan Mao, and Howard A. Rockman. “Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure.” J Clin Invest 112, no. 7 (October 2003): 1067–79. https://doi.org/10.1172/JCI18213.Full Text Link to Item
-
Barki-Harrington, Liza, Louis M. Luttrell, and Howard A. Rockman. “Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo.” Circulation 108, no. 13 (September 30, 2003): 1611–18. https://doi.org/10.1161/01.CIR.0000092166.30360.78.Full Text Link to Item
-
Rapacciuolo, Antonio, Shayela Suvarna, Liza Barki-Harrington, Louis M. Luttrell, Mei Cong, Robert J. Lefkowitz, and Howard A. Rockman. “Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.” J Biol Chem 278, no. 37 (September 12, 2003): 35403–11. https://doi.org/10.1074/jbc.M305675200.Full Text Link to Item
-
Most, Patrick, Andrew Remppis, Sven T. Pleger, Eva Löffler, Philipp Ehlermann, Juliane Bernotat, Christiane Kleuss, et al. “Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.” J Biol Chem 278, no. 36 (September 5, 2003): 33809–17. https://doi.org/10.1074/jbc.M301788200.Full Text Link to Item
-
Naga Prasad, Sathyamangla V., Cinzia Perrino, and Howard A. Rockman. “Role of phosphoinositide 3-kinase in cardiac function and heart failure.” Trends Cardiovasc Med 13, no. 5 (July 2003): 206–12. https://doi.org/10.1016/s1050-1738(03)00080-x.Full Text Link to Item
-
Le Corvoisier, P., H. Y. Park, and H. A. Rockman. “Modifier genes and heart failure.” Minerva Cardioangiol 51, no. 2 (April 2003): 107–20.Link to Item
-
Le Corvoisier, P., H. Y. Park, K. M. Carlson, M. P. Donahue, D. A. Marchuk, and H. A. Rockman. “Impact of genetic polymorphisms on heart failure prognosis.” Arch Mal Coeur Vaiss 96, no. 3 (March 2003): 197–206.Link to Item
-
Colomer, Josep M., Lan Mao, Howard A. Rockman, and Anthony R. Means. “Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo.” Mol Endocrinol 17, no. 2 (February 2003): 183–92. https://doi.org/10.1210/me.2002-0350.Full Text Link to Item
-
Barki-Harrington, Liza, and Howard A. Rockman. “Sensing heart stress.” Nat Med 9, no. 1 (January 2003): 19–20. https://doi.org/10.1038/nm0103-19.Full Text Link to Item
-
Esposito, Giovanni, Antonia Rapacciuolo, Sathyamangla V. Naga Prasad, and Howard A. Rockman. “Cardiac hypertrophy: role of G protein-coupled receptors.” J Card Fail 8, no. 6 Suppl (December 2002): S409–14. https://doi.org/10.1054/jcaf.2002.129283.Full Text Link to Item
-
Feldman, David S., A Musa Zamah, Kristen L. Pierce, William E. Miller, Francine Kelly, Antonio Rapacciuolo, Howard A. Rockman, Walter J. Koch, and Louis M. Luttrell. “Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.” J Biol Chem 277, no. 32 (August 9, 2002): 28631–40. https://doi.org/10.1074/jbc.M204753200.Full Text Link to Item
-
Naga Prasad, Sathyamangla V., Stéphane A. Laporte, Dean Chamberlain, Marc G. Caron, Larry Barak, and Howard A. Rockman. “Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.” J Cell Biol 158, no. 3 (August 5, 2002): 563–75. https://doi.org/10.1083/jcb.200202113.Full Text Link to Item
-
Takaoka, Hideyuki, Giovanni Esposito, Lan Mao, Hiroyuki Suga, and Howard A. Rockman. “Heart size-independent analysis of myocardial function in murine pressure overload hypertrophy.” Am J Physiol Heart Circ Physiol 282, no. 6 (June 2002): H2190–97. https://doi.org/10.1152/ajpheart.00759.2001.Full Text Link to Item
-
Suzuki, Miwako, Kerri M. Carlson, Douglas A. Marchuk, and Howard A. Rockman. “Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy.” Circulation 105, no. 15 (April 16, 2002): 1824–29. https://doi.org/10.1161/01.cir.0000014926.32463.89.Full Text Link to Item
-
Eckhart, Andrea D., Tohru Ozaki, Hendrik Tevaearai, Howard A. Rockman, and Walter J. Koch. “Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure.” Mol Pharmacol 61, no. 4 (April 2002): 749–58. https://doi.org/10.1124/mol.61.4.749.Full Text Link to Item
-
Rockman, Howard A., Walter J. Koch, and Robert J. Lefkowitz. “Seven-transmembrane-spanning receptors and heart function.” Nature 415, no. 6868 (January 10, 2002): 206–12. https://doi.org/10.1038/415206a.Full Text Link to Item
-
Esposito, Giovanni, Antonio Rapacciuolo, Sathyamangla V. Naga Prasad, Hideyuki Takaoka, Steven A. Thomas, Walter J. Koch, and Howard A. Rockman. “Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.” Circulation 105, no. 1 (January 1, 2002): 85–92. https://doi.org/10.1161/hc0102.101365.Full Text Link to Item
-
Prasad, SV Naga, J. Nienaber, and H. A. Rockman. “G-protein-coupled receptor function in heart failure.” Cold Spring Harb Symp Quant Biol 67 (2002): 439–44. https://doi.org/10.1101/sqb.2002.67.439.Full Text Link to Item
-
Kohout, T. A., H. Takaoka, P. H. McDonald, S. J. Perry, L. Mao, R. J. Lefkowitz, and H. A. Rockman. “Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.” Circulation 104, no. 20 (November 13, 2001): 2485–91. https://doi.org/10.1161/hc4501.098933.Full Text Open Access Copy Link to Item
-
Naga Prasad, S. V., J. Nienaber, and H. A. Rockman. “Beta-adrenergic axis and heart disease.” Trends Genet 17, no. 10 (October 2001): S44–49. https://doi.org/10.1016/s0168-9525(01)02487-8.Full Text Link to Item
-
Rapacciuolo, A., G. Esposito, K. Caron, L. Mao, S. A. Thomas, and H. A. Rockman. “Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy.” J Am Coll Cardiol 38, no. 3 (September 2001): 876–82. https://doi.org/10.1016/s0735-1097(01)01433-4.Full Text Link to Item
-
Rapacciuolo, A., G. Esposito, S. V. Prasad, and H. A. Rockman. “G protein-coupled receptor signalling in in vivo cardiac overload.” Acta Physiol Scand 173, no. 1 (September 2001): 51–57. https://doi.org/10.1046/j.1365-201X.2001.00884.x.Full Text Link to Item
-
Iaccarino, G., J. R. Keys, A. Rapacciuolo, K. F. Shotwell, R. J. Lefkowitz, H. A. Rockman, and W. J. Koch. “Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.” J Am Coll Cardiol 38, no. 2 (August 2001): 534–40. https://doi.org/10.1016/s0735-1097(01)01396-1.Full Text Link to Item
-
Ufret-Vincenty, C. A., D. J. Baro, W. J. Lederer, H. A. Rockman, L. E. Quinones, and L. F. Santana. “Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure.” J Biol Chem 276, no. 30 (July 27, 2001): 28197–203. https://doi.org/10.1074/jbc.M102548200.Full Text Link to Item
-
Naga Prasad, S. V., L. S. Barak, A. Rapacciuolo, M. G. Caron, and H. A. Rockman. “Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration.” J Biol Chem 276, no. 22 (June 1, 2001): 18953–59. https://doi.org/10.1074/jbc.M102376200.Full Text Link to Item
-
Harding, V. B., L. R. Jones, R. J. Lefkowitz, W. J. Koch, and H. A. Rockman. “Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.” Proc Natl Acad Sci U S A 98, no. 10 (May 8, 2001): 5809–14. https://doi.org/10.1073/pnas.091102398.Full Text Open Access Copy Link to Item
-
Knowles, J. W., G. Esposito, L. Mao, J. R. Hagaman, J. E. Fox, O. Smithies, H. A. Rockman, and N. Maeda. “Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice.” J Clin Invest 107, no. 8 (April 2001): 975–84. https://doi.org/10.1172/JCI11273.Full Text Link to Item
-
Esposito, G., S. V. Prasad, A. Rapacciuolo, L. Mao, W. J. Koch, and H. A. Rockman. “Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload.” Circulation 103, no. 10 (March 13, 2001): 1453–58. https://doi.org/10.1161/01.cir.103.10.1453.Full Text Link to Item
-
Esposito, G., L. F. Santana, K. Dilly, J. D. Cruz, L. Mao, W. J. Lederer, and H. A. Rockman. “Cellular and functional defects in a mouse model of heart failure.” Am J Physiol Heart Circ Physiol 279, no. 6 (December 2000): H3101–12. https://doi.org/10.1152/ajpheart.2000.279.6.H3101.Full Text Link to Item
-
Manning, B. S., K. Shotwell, L. Mao, H. A. Rockman, and W. J. Koch. “Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy.” Circulation 102, no. 22 (November 28, 2000): 2751–57. https://doi.org/10.1161/01.cir.102.22.2751.Full Text Link to Item
-
Brewis, N., K. Ohst, K. Fields, A. Rapacciuolo, D. Chou, C. Bloor, W. Dillmann, H. Rockman, and G. Walter. “Dilated cardiomyopathy in transgenic mice expressing a mutant A subunit of protein phosphatase 2A.” Am J Physiol Heart Circ Physiol 279, no. 3 (September 2000): H1307–18. https://doi.org/10.1152/ajpheart.2000.279.3.H1307.Full Text Link to Item
-
Lipskaia, L., N. Defer, G. Esposito, I. Hajar, M. C. Garel, H. A. Rockman, and J. Hanoune. “Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase.” Circ Res 86, no. 7 (April 14, 2000): 795–801. https://doi.org/10.1161/01.res.86.7.795.Full Text Link to Item
-
Lefkowitz, R. J., H. A. Rockman, and W. J. Koch. “Catecholamines, cardiac beta-adrenergic receptors, and heart failure.” Circulation 101, no. 14 (April 11, 2000): 1634–37. https://doi.org/10.1161/01.cir.101.14.1634.Full Text Open Access Copy Link to Item
-
Naga Prasad, S. V., G. Esposito, L. Mao, W. J. Koch, and H. A. Rockman. “Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy.” J Biol Chem 275, no. 7 (February 18, 2000): 4693–98. https://doi.org/10.1074/jbc.275.7.4693.Full Text Link to Item
-
Koch, W. J., R. J. Lefkowitz, and H. A. Rockman. “Functional consequences of altering myocardial adrenergic receptor signaling.” Annu Rev Physiol 62 (2000): 237–60. https://doi.org/10.1146/annurev.physiol.62.1.237.Full Text Link to Item
-
Akhter, S. A., A. D. Eckhart, H. A. Rockman, K. Shotwell, R. J. Lefkowitz, and W. J. Koch. “In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function.” Circulation 100, no. 6 (August 10, 1999): 648–53. https://doi.org/10.1161/01.cir.100.6.648.Full Text Open Access Copy Link to Item
-
Cho, M. C., A. Rapacciuolo, W. J. Koch, Y. Kobayashi, L. R. Jones, and H. A. Rockman. “Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression.” J Biol Chem 274, no. 32 (August 6, 1999): 22251–56. https://doi.org/10.1074/jbc.274.32.22251.Full Text Link to Item
-
Cho, M. C., M. Rao, W. J. Koch, S. A. Thomas, R. D. Palmiter, and H. A. Rockman. “Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.” Circulation 99, no. 20 (May 25, 1999): 2702–7. https://doi.org/10.1161/01.cir.99.20.2702.Full Text Link to Item
-
Rapacciuolo, A., and H. A. Rockman. “Role of β-adrenoceptor desensitization in heart failure.” Cardiovascular Drug Reviews 17, no. 4 (January 1, 1999): 384–94. https://doi.org/10.1111/j.1527-3466.1999.tb00027.x.Full Text
-
Choi, D. J., and H. A. Rockman. “Beta-adrenergic receptor desensitization in cardiac hypertrophy and heart failure.” Cell Biochem Biophys 31, no. 3 (1999): 321–29. https://doi.org/10.1007/BF02738246.Full Text Link to Item
-
Koch, W. J., and H. A. Rockman. “Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice.” Trends Cardiovasc Med 9, no. 3–4 (1999): 77–81. https://doi.org/10.1016/s1050-1738(99)00009-2.Full Text Link to Item
-
Iaccarino, Guido, Howard A. Rockman, Kyle F. Shotwell, Eric D. Tomhave, and Walter J. Koch. “Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs.” Am J Physiol Heart Circ Physiol 275, no. 4 (October 1, 1998): H1298–1306. https://doi.org/10.1152/ajpheart.1998.275.4.H1298.Full Text Link to Item
-
Neumann, J., P. Boknik, A. A. DePaoli-Roach, L. J. Field, H. A. Rockman, Y. M. Kobayashi, J. S. Kelley, and L. R. Jones. “Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility.” J Mol Cell Cardiol 30, no. 10 (October 1998): 1991–2002. https://doi.org/10.1006/jmcc.1998.0760.Full Text Link to Item
-
Tanaka, N., T. Ryoke, M. Hongo, L. Mao, H. A. Rockman, R. G. Clark, and J. Ross. “Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice.” Am J Physiol 275, no. 2 (August 1998): H393–99. https://doi.org/10.1152/ajpheart.1998.275.2.H393.Full Text Link to Item
-
Rockman, H. A., D. J. Choi, S. A. Akhter, M. Jaber, B. Giros, R. J. Lefkowitz, M. G. Caron, and W. J. Koch. “Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice.” J Biol Chem 273, no. 29 (July 17, 1998): 18180–84. https://doi.org/10.1074/jbc.273.29.18180.Full Text Link to Item
-
Rockman, H. A., K. R. Chien, D. J. Choi, G. Iaccarino, J. J. Hunter, J. Ross, R. J. Lefkowitz, and W. J. Koch. “Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.” Proc Natl Acad Sci U S A 95, no. 12 (June 9, 1998): 7000–7005. https://doi.org/10.1073/pnas.95.12.7000.Full Text Open Access Copy Link to Item
-
Akhter, S. A., L. M. Luttrell, H. A. Rockman, G. Iaccarino, R. J. Lefkowitz, and W. J. Koch. “Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.” Science 280, no. 5363 (April 24, 1998): 574–77. https://doi.org/10.1126/science.280.5363.574.Full Text Link to Item
-
Koch, W. J., R. J. Lefkowitz, C. A. Milano, S. A. Akhter, and H. A. Rockman. “Myocardial overexpression of adrenergic receptors and receptor kinases.” Adv Pharmacol 42 (1998): 502–6. https://doi.org/10.1016/s1054-3589(08)60799-1.Full Text Link to Item
-
Oliver, P. M., J. E. Fox, R. Kim, H. A. Rockman, H. S. Kim, R. L. Reddick, K. N. Pandey, S. L. Milgram, O. Smithies, and N. Maeda. “Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A.” Proc Natl Acad Sci U S A 94, no. 26 (December 23, 1997): 14730–35. https://doi.org/10.1073/pnas.94.26.14730.Full Text Link to Item
-
Choi, D. J., W. J. Koch, and H. A. Rockman. “Cardiac hypertrophy is associated with increased β-adrenergic receptor kinase (βARK).” Faseb Journal 11, no. 3 (December 1, 1997).
-
Akhter, S. A., C. A. Milano, K. F. Shotwell, M. C. Cho, H. A. Rockman, R. J. Lefkowitz, and W. J. Koch. “Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling.” J Biol Chem 272, no. 34 (August 22, 1997): 21253–59. https://doi.org/10.1074/jbc.272.34.21253.Full Text Link to Item
-
He, H., F. J. Giordano, R. Hilal-Dandan, D. J. Choi, H. A. Rockman, P. M. McDonough, W. F. Bluhm, et al. “Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation.” J Clin Invest 100, no. 2 (July 15, 1997): 380–89. https://doi.org/10.1172/JCI119544.Full Text Link to Item
-
Choi, D. J., W. J. Koch, J. J. Hunter, and H. A. Rockman. “Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase.” J Biol Chem 272, no. 27 (July 4, 1997): 17223–29. https://doi.org/10.1074/jbc.272.27.17223.Full Text Link to Item
-
Sack, M. N., D. L. Disch, H. A. Rockman, and D. P. Kelly. “A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program.” Proc Natl Acad Sci U S A 94, no. 12 (June 10, 1997): 6438–43. https://doi.org/10.1073/pnas.94.12.6438.Full Text Link to Item
-
Rockman, H. A., W. J. Koch, and R. J. Lefkowitz. “Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.” Am J Physiol 272, no. 4 Pt 2 (April 1997): H1553–59. https://doi.org/10.1152/ajpheart.1997.272.4.H1553.Full Text Link to Item
-
Ryu, K. H., N. Tanaka, N. Dalton, L. Mao, H. A. Rockman, C. A. Milano, and J. Ross. “Force-frequency relations in the failing rabbit heart and responses to adrenergic stimulation.” J Card Fail 3, no. 1 (March 1997): 27–39. https://doi.org/10.1016/s1071-9164(97)90006-3.Full Text Link to Item
-
Samama, P., R. A. Bond, H. A. Rockman, C. A. Milano, and R. J. Lefkowitz. “Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.” Proc Natl Acad Sci U S A 94, no. 1 (January 7, 1997): 137–41. https://doi.org/10.1073/pnas.94.1.137.Full Text Open Access Copy Link to Item
-
Cho, M. C., W. J. Koch, and H. A. Rockman. “Gene therapy for chronic heart failure.” Acc Current Journal Review 6, no. 2 (January 1, 1997): 56–58. https://doi.org/10.1016/S1062-1458(97)83289-8.Full Text
-
Rockman, H. A. “Uncoupling of G-protein coupled receptors in vivo: insights from transgenic mice.” Adv Exp Med Biol 430 (1997): 67–72. https://doi.org/10.1007/978-1-4615-5959-7_6.Full Text Link to Item
-
Kubalak, S. W., J. J. Hunter, K. R. Chien, P. A. Doevendans, H. A. Rockman, N. Tanaka, and J. Ross. “[26]Molecular analysis of cardiac muscle diseases based on mouse genetics.” Methods in Molecular Genetics 8, no. C (December 1, 1996): 470–87. https://doi.org/10.1016/S1067-2389(96)80059-8.Full Text
-
Lembo, G., H. A. Rockman, J. J. Hunter, H. Steinmetz, W. J. Koch, L. Ma, M. P. Prinz, J. Ross, K. R. Chien, and L. Powell-Braxton. “Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.” J Clin Invest 98, no. 11 (December 1, 1996): 2648–55. https://doi.org/10.1172/JCI119086.Full Text Link to Item
-
Jaber, M., W. J. Koch, H. Rockman, B. Smith, R. A. Bond, K. K. Sulik, J. Ross, R. J. Lefkowitz, M. G. Caron, and B. Giros. “Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.” Proc Natl Acad Sci U S A 93, no. 23 (November 12, 1996): 12974–79. https://doi.org/10.1073/pnas.93.23.12974.Full Text Open Access Copy Link to Item
-
Rockman, H. A., D. J. Choi, N. U. Rahman, S. A. Akhter, R. J. Lefkowitz, and W. J. Koch. “Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.” Proc Natl Acad Sci U S A 93, no. 18 (September 3, 1996): 9954–59. https://doi.org/10.1073/pnas.93.18.9954.Full Text Open Access Copy Link to Item
-
Tanaka, N., N. Dalton, L. Mao, H. A. Rockman, K. L. Peterson, K. R. Gottshall, J. J. Hunter, K. R. Chien, and J. Ross. “Transthoracic echocardiography in models of cardiac disease in the mouse.” Circulation 94, no. 5 (September 1, 1996): 1109–17. https://doi.org/10.1161/01.cir.94.5.1109.Full Text Link to Item
-
Rockman, H. A., W. J. Koch, C. A. Milano, and R. J. Lefkowitz. “Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice.” J Mol Med (Berl) 74, no. 9 (September 1996): 489–95. https://doi.org/10.1007/BF00204974.Full Text Link to Item
-
Swertfeger, D. K., D. P. Witte, W. D. Stuart, H. A. Rockman, and J. A. Harmony. “Apolipoprotein J/clusterin induction in myocarditis: A localized response gene to myocardial injury.” Am J Pathol 148, no. 6 (June 1996): 1971–83.Link to Item
-
Rockman, H. A., R. A. Hamilton, L. R. Jones, C. A. Milano, L. Mao, and R. J. Lefkowitz. “Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.” J Clin Invest 97, no. 7 (April 1, 1996): 1618–23. https://doi.org/10.1172/JCI118587.Full Text Open Access Copy Link to Item
-
Ben-Yehuda, O., and H. A. Rockman. “Regulation of myocardial contractility: Insights from transgenic mice.” Trends Cardiovasc Med 6, no. 3 (April 1996): 95–99. https://doi.org/10.1016/1050-1738(96)00010-2.Full Text Link to Item
-
Gulati, J., O. Ben-Yehuda, and H. A. Rockman. “Is cardiac troponin C the length sensor in Starling's law of the heart? (multiple letters).” Trends in Cardiovascular Medicine 6, no. 8 (January 1, 1996): 245–46. https://doi.org/10.1016/S1050-1738(96)00104-1.Full Text
-
Sack, M. N., D. L. Disch, T. A. Rader, H. A. Rockman, and D. P. Kelly. “Transcriptional downregulation of a mitochondria!. fatty acid oxidation enzyme gene in response to ventricular pressure overload.” Journal of Investigative Medicine 44, no. 3 (January 1, 1996).
-
Hunter, J. J., N. Tanaka, H. A. Rockman, J. Ross, and K. R. Chien. “Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.” J Biol Chem 270, no. 39 (September 29, 1995): 23173–78. https://doi.org/10.1074/jbc.270.39.23173.Full Text Link to Item
-
Knowlton, K. U., H. A. Rockman, M. Itani, A. Vovan, C. E. Seidman, and K. R. Chien. “Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium.” J Clin Invest 96, no. 3 (September 1995): 1311–18. https://doi.org/10.1172/JCI118166.Full Text Link to Item
-
Lin, M. C., H. A. Rockman, and K. R. Chien. “Heart and lung disease in engineered mice.” Nat Med 1, no. 8 (August 1995): 749–51. https://doi.org/10.1038/nm0895-749.Full Text Link to Item
-
Koch, W. J., H. A. Rockman, P. Samama, R. A. Hamilton, R. A. Bond, C. A. Milano, and R. J. Lefkowitz. “Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.” Science 268, no. 5215 (June 2, 1995): 1350–53. https://doi.org/10.1126/science.7761854.Full Text Link to Item
-
Penny, W. F., H. Rockman, J. Long, V. Bhargava, K. Carrigan, A. Ibriham, R. Shabetai, J. Ross, and K. L. Peterson. “Heterogeneity of vasomotor response to acetylcholine along the human coronary artery.” J Am Coll Cardiol 25, no. 5 (April 1995): 1046–55. https://doi.org/10.1016/0735-1097(94)00537-z.Full Text Link to Item
-
Bond, R. A., P. Leff, T. D. Johnson, C. A. Milano, H. A. Rockman, T. R. McMinn, S. Apparsundaram, M. F. Hyek, T. P. Kenakin, and L. F. Allen. “Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor.” Nature 374, no. 6519 (March 16, 1995): 272–76. https://doi.org/10.1038/374272a0.Full Text Link to Item
-
Milano, C. A., L. F. Allen, P. C. Dolber, T. D. Johnson, H. A. Rockman, R. A. Bond, and R. J. Lefkowitz. “Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene.” J Thorac Cardiovasc Surg 109, no. 2 (February 1995): 236–41. https://doi.org/10.1016/s0022-5223(95)70384-5.Full Text Link to Item
-
Milano, C. A., P. C. Dolber, H. A. Rockman, R. A. Bond, M. E. Venable, L. F. Allen, and R. J. Lefkowitz. “Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.” Proc Natl Acad Sci U S A 91, no. 21 (October 11, 1994): 10109–13. https://doi.org/10.1073/pnas.91.21.10109.Full Text Open Access Copy Link to Item
-
Rockman, H. A., S. P. Wachhorst, L. Mao, and J. Ross. “ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice.” Am J Physiol 266, no. 6 Pt 2 (June 1994): H2468–75. https://doi.org/10.1152/ajpheart.1994.266.6.H2468.Full Text Link to Item
-
Milano, C. A., L. F. Allen, H. A. Rockman, P. C. Dolber, T. R. McMinn, K. R. Chien, T. D. Johnson, R. A. Bond, and R. J. Lefkowitz. “Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.” Science 264, no. 5158 (April 22, 1994): 582–86. https://doi.org/10.1126/science.8160017.Full Text Link to Item
-
Rockman, H. A., S. Ono, R. S. Ross, L. R. Jones, M. Karimi, V. Bhargava, J. Ross, and K. R. Chien. “Molecular and physiological alterations in murine ventricular dysfunction.” Proc Natl Acad Sci U S A 91, no. 7 (March 29, 1994): 2694–98. https://doi.org/10.1073/pnas.91.7.2694.Full Text Link to Item
-
Ono, S., V. Bhargava, L. Mao, G. Hagan, H. A. Rockman, and J. Ross. “In vivo assessment of left ventricular remodelling after myocardial infarction by digital video contrast angiography in the rat.” Cardiovasc Res 28, no. 3 (March 1994): 349–57. https://doi.org/10.1093/cvr/28.3.349.Full Text Link to Item
-
Omens, J. H., H. A. Rockman, and J. W. Covell. “Passive ventricular mechanics in tight-skin mice.” Am J Physiol 266, no. 3 Pt 2 (March 1994): H1169–76. https://doi.org/10.1152/ajpheart.1994.266.3.H1169.Full Text Link to Item
-
Oh, B. H., S. Ono, H. A. Rockman, and J. Ross. “Myocardial hypertrophy in the ischemic zone induced by exercise in rats after coronary reperfusion.” Circulation 87, no. 2 (February 1993): 598–607. https://doi.org/10.1161/01.cir.87.2.598.Full Text Link to Item
-
Rockman, H. A., K. U. Knowlton, J. Ross, and K. R. Chien. “In vivo murine cardiac hypertrophy: A novel model to identify genetic signaling mechanisms that activate an adaptive physiological response.” Circulation 87, no. 6 SUPPL. VII (January 1, 1993).
-
Kambayashi, M., T. Miura, B. H. Oh, K. Murata, H. A. Rockman, G. Parra, and J. Ross. “Myocardial cell hypertrophy after myocardial infarction with reperfusion in dogs.” Circulation 86, no. 6 (December 1992): 1935–44. https://doi.org/10.1161/01.cir.86.6.1935.Full Text Link to Item
-
Oh, B. H., M. Volpini, M. Kambayashi, K. Murata, H. A. Rockman, G. S. Kassab, and J. Ross. “Myocardial function and transmural blood flow during coronary venous retroperfusion in pigs.” Circulation 86, no. 4 (October 1992): 1265–79. https://doi.org/10.1161/01.cir.86.4.1265.Full Text Link to Item
-
Lee, K. J., R. S. Ross, H. A. Rockman, A. N. Harris, T. X. O’Brien, M. van Bilsen, H. E. Shubeita, R. Kandolf, G. Brem, and J. Price. “Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene.” J Biol Chem 267, no. 22 (August 5, 1992): 15875–85.Link to Item
-
Kambayashi, M., T. Miura, B. H. Oh, H. A. Rockman, K. Murata, and J. Ross. “Enhancement of the force-frequency effect on myocardial contractility by adrenergic stimulation in conscious dogs.” Circulation 86, no. 2 (August 1992): 572–80. https://doi.org/10.1161/01.cir.86.2.572.Full Text Link to Item
-
Rockman, H. A., and K. U. Knowlton. “Peripartum vascular collapse Dissection of a genetic disease.” Trends Cardiovasc Med 2, no. 4 (July 1992): 125–28. https://doi.org/10.1016/1050-1738(92)90018-N.Full Text Link to Item
-
Miyamoto, M. I., H. A. Rockman, B. D. Guth, G. Heusch, and J. Ross. “Effect of alpha-adrenergic stimulation on regional contractile function and myocardial blood flow with and without ischemia.” Circulation 84, no. 4 (October 1991): 1715–24. https://doi.org/10.1161/01.cir.84.4.1715.Full Text Link to Item
-
Rockman, H. A., R. S. Ross, A. N. Harris, K. U. Knowlton, M. E. Steinhelper, L. J. Field, J. Ross, and K. R. Chien. “Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.” Proc Natl Acad Sci U S A 88, no. 18 (September 15, 1991): 8277–81. https://doi.org/10.1073/pnas.88.18.8277.Full Text Link to Item
-
Rockman, H. A., R. M. Adamson, W. P. Dembitsky, J. W. Bonar, and B. E. Jaski. “Acute fulminant myocarditis: long-term follow-up after circulatory support with left ventricular assist device.” Am Heart J 121, no. 3 Pt 1 (March 1991): 922–26. https://doi.org/10.1016/0002-8703(91)90213-2.Full Text Link to Item
-
Rockman, H. A., R. S. Ross, A. N. Harris, K. U. Knowlton, M. E. Steinhelper, L. J. Field, J. Ross, and K. R. Chien. “Erratum: Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy (Proc. Natl. Acad. Sci. USA (September 1991) 88 (8277-8281)).” Proceedings of the National Academy of Sciences of the United States of America 88, no. 21 (January 1, 1991): 9907. https://doi.org/10.1073/pnas.88.21.9907a.Full Text
-
Rockman, H. A., C. Juneau, K. Chatterjee, and J. L. Rouleau. “Long-term predictors of sudden and low output death in chronic congestive heart failure secondary to coronary artery disease.” Am J Cardiol 64, no. 19 (December 1, 1989): 1344–48. https://doi.org/10.1016/0002-9149(89)90579-1.Full Text Link to Item
-
Germinario, R. J., H. Rockman, M. Oliveira, S. Manuel, and M. Taylor. “Regulation of sugar transport in cultured diploid human skin fibroblasts.” J Cell Physiol 112, no. 3 (September 1982): 367–72. https://doi.org/10.1002/jcp.1041120309.Full Text Link to Item
-
-
Book Sections
-
Pfeiffer, Conrad T., Joao A. Paulo, Steven P. Gygi, and Howard A. Rockman. “Proximity labeling for investigating protein-protein interactions.,” 169:237–66, 2022. https://doi.org/10.1016/bs.mcb.2021.12.006.Full Text Link to Item
-
Perrino, C., and H. A. Rockman. “Modulating G protein-coupled receptors to effect reverse cardiac remodeling.” In Cardiac Remodeling: Molecular Mechanisms, 159–77, 2013. https://doi.org/10.1007/978-1-4614-5930-9_10.Full Text
-
-
Other Articles
-
Willerson, J. T. “Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.” Circulation, August 1, 1995. https://doi.org/10.1161/01.cir.92.3.277.Full Text Link to Item
-
-
Conference Papers
-
Wang, Jialu, Ilhan Gokhan, Xinyu Xiong, Alem W. Kahsai, Haoran Jiang, Conrad T. Pfeiffer, William Tian, et al. “Abstract MP133: Development of β-arrestin-biased Positive Allosteric Modulators for the β 1 Adrenergic Receptor.” In Circulation Research, Vol. 127. Ovid Technologies (Wolters Kluwer Health), 2020. https://doi.org/10.1161/res.127.suppl_1.mp133.Full Text
-
Pfeiffer, Conrad T., Clarice Gareri, Joao A. Paulo, Dean P. Staus, Laura M. Wingler, Steven P. Gygi, and Howard A. Rockman. “Mechanoactivation of Angiotensin II Type 1 Receptor Induces a Unique Phosphorylation "Barcode" Compared to Activation by Angiotensin II and [beta]-Arrestin Biased Ligand, TRV120023.” In Circulation, Vol. 138, 2018.Link to Item
-
Wang, Jialu, Samuel Mon-Wei Yu, Qiang Chen, Christopher V. Nicchitta, and Howard A. Rockman. “Transcriptional and Translational Regulatory Dynamics in Cardiomyocytes During Homeostasis and Physiological Stress Revealed by Ribosome Profiling.” In Circulation, Vol. 138, 2018.Link to Item
-
Gareri, Clarice, Joao A. Paulo, Alem W. Kashai, Jialu Wang, Kenji Hanada, Dean P. Staus, Laura M. Wingler, Steven P. Gygi, and Howard A. Rockman. “Mechanical Stretch Activates Biased AT1R Signaling Through a Unique B-arrestin Conformation.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.Link to Item
-
Gareri, Clarice, Jialu Wang, Kenji Hanada, Alem W. Kashai, Xinyu Xiong, Sudarshan Rajagopal, and Howard A. Rockman. “Mechanical Stretch Activates Biased AT1R Signaling and a Distinct [beta]-arrestin Conformation.” In Circulation Research, Vol. 121. LIPPINCOTT WILLIAMS & WILKINS, 2017.Link to Item
-
Jean-Charles, Pierre-Yves, Samuel Mon-Wei Yu, Lan Mao, Reddy Perra Kommadi, Zhushan Zhang, Jonathan Stiber, Dawn Bowles, et al. “Beta(1)-Adrenergic Receptor-induced Cardiac Contractility is dependent on MDM2-mediated GRK2 Turnover.” In Circulation Research, 119:E162–63. LIPPINCOTT WILLIAMS & WILKINS, 2016.Link to Item
-
Torok, Rachel D., Dennis M. Abraham, Clarice Gareri, Lan Mao, and Howard A. Rockman. “TWIK-Related Acid-Sensitive K+ Channels Affect the Development of Aortic Root Aneurysms in Mice.” In Circulation, Vol. 134. LIPPINCOTT WILLIAMS & WILKINS, 2016.Link to Item
-
Kirk, Jonathan A., Khalid Chakir, Kyounghwan Lee, Gianluigi Pironti, Mark J. Ranek, Richard S. Tunin, Pieter de Tombe, et al. “Pacemaker Induced Transient Asynchrony (PITA) Restores Contractile Reserve in Synchronous Heart Failure.” In Circulation Research, Vol. 117. LIPPINCOTT WILLIAMS & WILKINS, 2015.Link to Item
-
Wang, Jialu, Kunhong Xiao, and Howard A. Rockman. “Carvedilol Stimulated Gai-beta-Arrestin Biased beta 1 Adrenergic Receptor Signaling.” In Circulation Research, Vol. 117. LIPPINCOTT WILLIAMS & WILKINS, 2015.Link to Item
-
Abraham, Dennis M., Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Matthew J. Wolf, and Howard A. Rockman. “TREK-1 Modulates Fibrosis & Diastolic Dysfunction Through Activation of Stress-Activated Kinases.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.Link to Item
-
Kim, Il-Man, Yongchao Wang, Kyoung-mi Park, Christopher J. Traynham, Lan Mao, Walter J. Koch, and Howard A. Rockman. “beta-arrestin1-Biased beta 1-adrenergic Receptor Signaling Regulates MicroRNA Processing.” In Circulation Research, Vol. 113. LIPPINCOTT WILLIAMS & WILKINS, 2013.Link to Item
-
Tang, Hao, Kunhong Xiao, Lan Mao, Howard A. Rockman, and Douglas A. Marchuk. “Overexpression of Cardiac Troponin I-Interacting Kinase, a Cardiac-Specific MAPKKK, Promotes Cardiac Dysfunction.” In Circulation Research, Vol. 111. LIPPINCOTT WILLIAMS & WILKINS, 2012.Link to Item
-
Tang, Wei, and Howard A. Rockman. “AT1R Conformation Mediates Mechanical Stress-Induced beta-Arrestin Signaling.” In Circulation Research, Vol. 111. LIPPINCOTT WILLIAMS & WILKINS, 2012.Link to Item
-
Tilley, Douglas G., Nguyen Anny, and Howard A. Rockman. “AT1(A)R-beta-arrestin signaling confers PPAR gamma agonist-mediated myocyte contractility.” In Faseb Journal, Vol. 24. FEDERATION AMER SOC EXP BIOL, 2010.Link to Item
-
Kim, Il-Man, Matthew J. Wolf, and Howard A. Rockman. “Gene Deletion Screen for Cardiomyopathy in Adult Drosophila Identifies Weary (Wry): A New Notch Ligand.” In Circulation, 120:S743–S743. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
-
Mangmool, Supachoke, Weili Zou, Lan Mao, and Howard A. Rockman. “beta-Arrestin-Dependent Activation of Ca2+/Calmodulin-Dependent Kinase II Following beta(1)-Adrenergic Receptor Activation.” In Circulation, 120:S1147–S1147. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
-
Patel, Chetan B., Priyesh A. Patel, Stephan G. Frangakis, Minyong Chen, Sudha K. Shenoy, Robert J. Lefkowitz, and Howard A. Rockman. “A Modified beta 1-adrenergic Receptor Demonstrates Bias Towards G Protein Receptor Kinase Phosphorylation.” In Circulation, 120:S800–801. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
-
Yoo, ByungSu, Kriti Rakesh, Lan Mao, and Howard A. Rockman. “Mechanical Stretch Activates beta-arrestin-mediated Signaling of the AT1 Receptor.” In Circulation, 120:S866–S866. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
-
Tilley, Douglas G., and Howard A. Rockman. “[beta]1 adrenergic receptor ([beta]1AR)-epidermal growth factor receptor (EGFR) interaction regulates ERK cellular activity.” In Faseb Journal, Vol. 22. FEDERATION AMER SOC EXP BIOL, 2008.Link to Item
-
Kim, Il-Man, Michelle E. Casad, Matthew J. Wolf, and Howard A. Rockman. “Gene deletion screen in adult Drosophila identifies possible candidate gene for dilated cardiomyopathy.” In Circulation Research, 101:1207–8. LIPPINCOTT WILLIAMS & WILKINS, 2007.Link to Item
-
Kim, Il-Man, Douglas G. Tilley, Juhsien Chen, Natasha C. Salazar, Erin J. Whalen, and Howard A. Rockman. “The beta-blocker alprenolol stimulates beta-arrestin mediated epidermal growth factor receptor transactivation.” In Circulation, 116:273–273. LIPPINCOTT WILLIAMS & WILKINS, 2007.Link to Item
-
Seth, Malini, Zhu-Shan Zhang, Lan Mao, Jarrett Burch, Victoria Graham, Howard A. Rockman, Lutz Birnbaumer, and Paul Rosenberg. “Transient receptor potential channel C1 deficiency protects the murine heart from pressure overload.” In Circulation, 116:5–5. LIPPINCOTT WILLIAMS & WILKINS, 2007.Link to Item
-
ROCKMAN, H. “Heptahelical receptor signaling in heart failure.” In Journal of Molecular and Cellular Cardiology, 41:1039–1039. Elsevier BV, 2006. https://doi.org/10.1016/j.yjmcc.2006.08.020.Full Text
-
Chen, Juhsien, Sathyamangla V. Naga Prasad, Douglas G. Tilley, Robert J. Lefkowitz, and Howard A. Rockman. “beta-arrestin mediated beta 1-adrenergic receptor transactivartion of the epidermal growth factor receptor requires GRK 5 and 6.” In Circulation, 114:159–159. LIPPINCOTT WILLIAMS & WILKINS, 2006.Link to Item
-
Fernandez, Lillana, Douglas A. Marchuk, Jennifer Moran, David R. Beier, and Howard A. Rockman. “An N-ethyl-N-nitrosourea mutagenesis screen identifies the proximal end of chromosome 1 as a candidate region for murine cardiomyopathy.” In Circulation, 114:166–166. LIPPINCOTT WILLIAMS & WILKINS, 2006.Link to Item
-
Bhargava, V., G. Hagan, M. I. Miyamoto, S. Ono, H. Rockman, and J. Ross. “Systolic and diastolic global right and left ventricular function assessment in small animals using an automated angiographic technique.” In Proceedings Computers in Cardiology, Cic 1992, 191–94, 1992. https://doi.org/10.1109/CIC.1992.269414.Full Text
-
-
- Teaching & Mentoring
-
Recent Courses
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.