Phenotypic and functional characterization of human malignant T cells.

Journal Article (Journal Article;Review)

Malignancies of thymus-derived (T) lymphocytes can be divided into two major groups: diseases of T cells expressing immature T cell markers (T-ALL, T cell lymphoblastic lymphoma) and diseases of malignant T cells expressing markers in a pattern similar to normal mature T cells (T cell CLL, ATL, various forms of CTCL, and T-PLL). Until specific pathways of normal cell maturation are known, the relationship of phenotypic expression of various T cell markers by malignant T cells to a particular stage of normal T cell differentiation must remain speculative. However, phenotypic characterization of malignant T cells is an important first step in the study of events that transpire in the development of T cell malignancies. Future parallel study into the mechanisms of normal and aberrant T cell maturation will undoubtedly lead to greater understanding of the pathogenesis of the T cell malignancies, and therefore pave the way for specific therapies for these difficult-to-treat syndromes.

Full Text

Duke Authors

Cited Authors

  • Harden, EA; Haynes, BF

Published Date

  • January 1, 1985

Published In

Volume / Issue

  • 22 / 1

Start / End Page

  • 13 - 26

PubMed ID

  • 3918348

International Standard Serial Number (ISSN)

  • 0037-1963


  • eng

Conference Location

  • United States