Phenotypic and functional characterization of human malignant T cells.
Journal Article (Journal Article;Review)
Malignancies of thymus-derived (T) lymphocytes can be divided into two major groups: diseases of T cells expressing immature T cell markers (T-ALL, T cell lymphoblastic lymphoma) and diseases of malignant T cells expressing markers in a pattern similar to normal mature T cells (T cell CLL, ATL, various forms of CTCL, and T-PLL). Until specific pathways of normal cell maturation are known, the relationship of phenotypic expression of various T cell markers by malignant T cells to a particular stage of normal T cell differentiation must remain speculative. However, phenotypic characterization of malignant T cells is an important first step in the study of events that transpire in the development of T cell malignancies. Future parallel study into the mechanisms of normal and aberrant T cell maturation will undoubtedly lead to greater understanding of the pathogenesis of the T cell malignancies, and therefore pave the way for specific therapies for these difficult-to-treat syndromes.
Full Text
Duke Authors
Cited Authors
- Harden, EA; Haynes, BF
Published Date
- January 1, 1985
Published In
Volume / Issue
- 22 / 1
Start / End Page
- 13 - 26
PubMed ID
- 3918348
International Standard Serial Number (ISSN)
- 0037-1963
Language
- eng
Conference Location
- United States