Effect of pregnancy and human immunodeficiency virus infection on intracellular interleukin-2 production patterns.

Published

Journal Article

Human immunodeficiency virus type 1 (HIV-1) infection decreases the production of interleukin-2 (IL-2) from CD4+ and CD8+ T cells. Recombinant IL-2 (rIl-2) has been given to HIV-infected individuals to generate significant increases in CD4+ T-cell counts. There are limited data regarding the effects of pregnancy and HIV infection on IL-2 production in humans. To investigate the effects of human pregnancy, HIV infection, and HIV therapy on IL-2 production, we evaluated 61 women. Intracellular IL-2 production by CD4+ T cells from nonpregnant HIV-infected women was significantly lower than in that in uninfected women (45% +/- 8% versus 52% +/- 8%, P = 0.04). In contrast, there was no difference in levels of intracellular IL-2 production between HIV-infected and uninfected pregnant women. These observations suggest that pregnancy may down-regulate IL-2 production regardless of HIV infection status. Future studies should evaluate IL-2 production patterns in larger cohorts of women so that the physiological significance of IL-2 down-regulation in pregnancy can be further evaluated. This information is essential to assess the possible use of IL-2 supplementation therapy as a means of enhancing immune responses among HIV-infected pregnant women.

Full Text

Duke Authors

Cited Authors

  • Sutton, MY; Holland, B; Denny, TN; Garcia, A; Garcia, Z; Stein, D; Bardeguez, AD

Published Date

  • July 1, 2004

Published In

Volume / Issue

  • 11 / 4

Start / End Page

  • 780 - 785

PubMed ID

  • 15242957

Pubmed Central ID

  • 15242957

International Standard Serial Number (ISSN)

  • 1071-412X

Digital Object Identifier (DOI)

  • 10.1128/CDLI.11.4.780-785.2004

Language

  • eng

Conference Location

  • United States