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RADAR realistic animal model series for dose assessment.

Publication ,  Journal Article
Keenan, MA; Stabin, MG; Segars, WP; Fernald, MJ
Published in: J Nucl Med
March 2010

UNLABELLED: Rodent species are widely used in the testing and approval of new radiopharmaceuticals, necessitating murine phantom models. As more therapy applications are being tested in animal models, calculating accurate dose estimates for the animals themselves becomes important to explain and control potential radiation toxicity or treatment efficacy. Historically, stylized and mathematically based models have been used for establishing doses to small animals. Recently, a series of anatomically realistic human phantoms was developed using body models based on nonuniform rational B-spline. Realistic digital mouse whole-body (MOBY) and rat whole-body (ROBY) phantoms were developed on the basis of the same NURBS technology and were used in this study to facilitate dose calculations in various species of rodents. METHODS: Voxel-based versions of scaled MOBY and ROBY models were used with the Vanderbilt multinode computing network (Advanced Computing Center for Research and Education), using geometry and tracking radiation transport codes to calculate specific absorbed fractions (SAFs) with internal photon and electron sources. Photon and electron SAFs were then calculated for relevant organs in all models. RESULTS: The SAF results were compared with values from similar studies found in reference literature. Also, the SAFs were used with standardized decay data to develop dose factors to be used in radiation dose calculations. Representative plots were made of photon electron SAFs, evaluating the traditional assumption that all electron energy is absorbed in the source organs. CONCLUSION: The organ masses in the MOBY and ROBY models are in reasonable agreement with models presented by other investigators noting that considerable variation can occur between reported masses. Results consistent with those found by other investigators show that absorbed fractions for electrons for organ self-irradiation were significantly less than 1.0 at energies above 0.5 MeV, as expected for many of these small-sized organs, and measurable cross-irradiation was observed for many organ pairs for high-energy electrons (as would be emitted by nuclides such as (32)P, (90)Y, or (188)Re).

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Published In

J Nucl Med

DOI

EISSN

1535-5667

Publication Date

March 2010

Volume

51

Issue

3

Start / End Page

471 / 476

Location

United States

Related Subject Headings

  • Rats
  • Radiation Dosage
  • Phantoms, Imaging
  • Organ Size
  • Nuclear Medicine & Medical Imaging
  • Models, Biological
  • Models, Animal
  • Mice
  • Male
  • Humans
 

Citation

APA
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Keenan, M. A., Stabin, M. G., Segars, W. P., & Fernald, M. J. (2010). RADAR realistic animal model series for dose assessment. J Nucl Med, 51(3), 471–476. https://doi.org/10.2967/jnumed.109.070532
Keenan, Mary A., Michael G. Stabin, William P. Segars, and Michael J. Fernald. “RADAR realistic animal model series for dose assessment.J Nucl Med 51, no. 3 (March 2010): 471–76. https://doi.org/10.2967/jnumed.109.070532.
Keenan MA, Stabin MG, Segars WP, Fernald MJ. RADAR realistic animal model series for dose assessment. J Nucl Med. 2010 Mar;51(3):471–6.
Keenan, Mary A., et al. “RADAR realistic animal model series for dose assessment.J Nucl Med, vol. 51, no. 3, Mar. 2010, pp. 471–76. Pubmed, doi:10.2967/jnumed.109.070532.
Keenan MA, Stabin MG, Segars WP, Fernald MJ. RADAR realistic animal model series for dose assessment. J Nucl Med. 2010 Mar;51(3):471–476.

Published In

J Nucl Med

DOI

EISSN

1535-5667

Publication Date

March 2010

Volume

51

Issue

3

Start / End Page

471 / 476

Location

United States

Related Subject Headings

  • Rats
  • Radiation Dosage
  • Phantoms, Imaging
  • Organ Size
  • Nuclear Medicine & Medical Imaging
  • Models, Biological
  • Models, Animal
  • Mice
  • Male
  • Humans